Emerging Infectious Diseases Training Program

描述(申请人提供)：严重急性呼吸系统综合症(SARS)的出现，高致病性流感大流行的可能性，以及2001年炭疽病袭击的发人深省的现实，强调了自然和人造传染病生物对人类健康构成的危险。对传染病威胁的有效应对需要精通传染病生物学和控制以及生物防御准备的个人。沃兹沃斯中心2001年的炭疽测试计划以及随后的SARS和流感项目证明了这种准备。建议为实验室科学方面的博士后和博士后研究员提供培训计划，并丰富流行病学内容，以满足对具有新发感染和生物防御科学专业知识的科学家的这一需求。该计划的目标是提供基础研究和应用研究相结合的多学科培训，以产生：(1)具有新发传染病和生物防御背景的博士毕业生；(2)能够成为独立科学家的博士后研究员，开发新发感染和生物防御方面的综合研究计划。来自纽约州立大学奥尔巴尼分校公共卫生学院沃兹沃斯中心和纽约州卫生部科学办公室的10名资金雄厚的导师和5名副导师是通过学术任命产生的。这种独特的训练环境将基础研究与传染病爆发和生物防御反应结合在一起。该培训计划的主要组成部分是基于生物医学科学系和流行病学系的现有课程。教学内容包括生物化学、细胞生物学、微生物学、病毒学、分子遗传学、微生物发病机制、免疫学和传染病流行病学，重点是公共卫生和疾病传播的生物学基础。一套关于新兴感染和生物防御学的课程介绍了生物安全程序、BSL3病原体遏制、病原体检测以及生物恐怖主义事件和反应建模。研究员参加临床相关的实验室轮换和学术讨论会，以及涵盖高级主题和当前文献的期刊俱乐部。新兴感染研究研讨会系列建立在现有的沃兹沃斯中心和卫生部研讨会计划的基础上。指导委员会和咨询委员会，以及现有的奥尔巴尼大学公共卫生学院学术结构，确保高质量的申请者进入这个专业项目，并确保博士后和博士后学生成为该研究领域的多产科学家。 相关性：严重急性呼吸系统综合症(SARS)的出现，高致病性流感大流行的可能性，以及2001年炭疽病袭击的发人深省的现实，强调了自然和人为传染病生物对人类健康构成的危险。这项申请建议培养博士后和博士后科学家，以应对这种对国家公共卫生的威胁。

DESCRIPTION (provided by applicant): The emergence of Severe Acute Respiratory Syndrome (SARS), potential for a highly pathogenic influenza pandemic, and sobering reality of the 2001 anthrax attacks emphasize the danger to human health posed by infectious organisms, both natural and man-made. An effective response to infectious threats requires individuals well versed in infectious disease biology and control, as well as biodefense preparedness. Such preparedness was demonstrated by Wadsworth Center's anthrax testing initiative in 2001, as well as its subsequent SARS and influenza programs. A training program for predoctoral and postdoctoral fellows in the laboratory sciences, with an epidemiology enrichment, is proposed to meet this need for scientists with expertise in emerging infections and biodefense sciences. The goal of this program is to provide multi-disciplinary training combining basic and applied research to produce: (1) doctoral graduates with backgrounds in emerging infectious diseases and biodefense; and (2) postdoctoral fellows who can become independent scientists developing integrated research programs in emerging infections and biodefense. Ten well-funded mentors and five associate mentors are drawn from the Wadsworth Center and the Office of Science of the New York State Department of Health, through their academic appointments within the School of Public Health, University at Albany, SUNY. This unique training environment combines fundamental research with infectious disease outbreak and biodefense response. The training program's key components are based on the existing curriculum of the Departments of Biomedical Sciences and Epidemiology. Didactic components include grounding in biochemistry, cell biology, microbiology, virology, molecular genetics, microbial pathogenesis, immunology, and infectious disease epidemiology with a focus on the biological basis of public health and disease transmission. A set of courses on Emerging Infections and Biodefense Sciences introduces biosafety procedures, BSL3 pathogen containment, pathogen detection, and bioterrorism event and response modeling. Fellows participate in clinically relevant laboratory rotations and colloquia, and journal clubs covering advanced topics and the current literature. An emerging infections research seminar series builds on existing Wadsworth Center and Department of Health seminar programs. The steering and advisory committees, and the existing University at Albany, School of Public Health academic structures, ensure that high-quality applicants enter this specialized program and that both pre- and postdoctoral students become productive scientists in this research area. RELEVANCE: The emergence of Severe Acute Respiratory Syndrome (SARS), potential for a highly pathogenic influenza pandemic, and sobering reality of the 2001 anthrax attacks emphasize the danger to human health posed by infectious organisms, both natural and man-made. This application proposes to train pre- and postdoctoral scientists to combat such threats to the nation's public health.