Multidisciplinary K12 Urologic Research (KURe) Career Development Program

描述（由申请人提供）：本申请旨在为贝勒医学院斯科特泌尿科和生殖医学中心的多学科K12泌尿研究（KURe）职业发展计划的竞争更新申请提供支持。该项目的研究重点是儿科泌尿学/泌尿生殖系统发育，类固醇激素作用，干细胞遗传学和下尿路症状（LUTS）。培训师资包括7名博士/医学博士兰姆博士将担任KURe职业发展计划的项目主任和行政主任。Boone博士将担任联席主任。Drs。Lipshultz, Cunningham, Gonzales, Khera, Roth， Janzen将确保医学博士学员在男性健康和儿科泌尿外科的泌尿外科亚专科领域得到最佳培训。主要研究领域包括：泌尿生殖系统发育缺陷的遗传学和基因组学、细胞生物学、类固醇激素受体、男性生殖道生物学、遗传学、细胞周期控制、干细胞、基因治疗和LUTS。受训者将是贝勒医学院的医学博士和博士初级教员。我们的项目吸引高素质的学员，他们在泌尿外科研究中寻求密集和实质性的研究培训，重点是临床翻译。我们有一个明确的招聘计划，强调招聘妇女和少数民族。培训环境的优势包括备受尊敬，资金充足，经验丰富的教师，NIH在泌尿科/细胞生物学/遗传学/病理学部门的资助排名居全国前列，有必修课程的结构化指导计划，有相关课程的细胞生物学研究生计划，以及细胞生物学和遗传学的深度。最重要的是，我们在培养成功的内科科学家方面有着良好的记录。我们的长期目标是培训这些年轻的研究人员，使他们能够成功地竞争同行评议的资金，并最终增加男性生殖健康研究的基础和转化研究工作。

DESCRIPTION (provided by applicant): This application seeks support for our competing renewal application for the Multidisciplinary K12 Urologic Research (KURe) Career Development Program to the Scott Department of Urology and the Center for Reproductive Medicine at Baylor College of Medicine. The research emphasis of this program is in the areas pediatric urology/genitourinary development, steroid hormone action, stem cells genetics and lower urinary tract symptoms (LUTS). The training faculty includes 7 Ph.D/M.D., Ph.D. faculty and11 M.D.s. Dr. Lamb will serve as both the Program Director and the Administrative Director of the KURe career development program. Dr. Boone will serve as co-Director. Drs. Lipshultz, Cunningham, Gonzales, Khera, Roth, Janzen will ensure the M.D. trainees are optimally trained in the urologic subspecialty areas of men's health and pediatric urology. The major research areas in the program include: genetics and genomics of genitourinary developmental defects, cell biology, steroid hormone receptors, male reproductive tract biology, genetics, cell cycle control, stem cells, gene therapy and LUTS. The trainees will be M.D. and Ph.D. junior faculty members at Baylor College of Medicine. Our program attracts highly qualified trainees who seek intensive and substantial research training in urology research with an emphasis on clinical translation. We have a defined recruitment plan that emphasizes the recruitment of women and minorities. The strengths of the training environment include highly respected, well-funded, experienced faculty, the high ranking national ranking for NIH funding of a Urology/Cell Biology/Genetics/Pathology departments, a structured mentoring program with required coursework, a cell biology graduate program with relevant course work and depth in both cell biology and genetics. Most importantly, we have a strong track record of training successful physician scientists. Our long- term goal is to train these young investigators to successfully compete for peer-reviewed funding and eventually to increase basic and translational research efforts in men's reproductive health research.