Investigating the pathogenesis of motor neuron disease using zebrafish models

肌萎缩侧索硬化症(ALS)导致运动神经进行性死亡。大多数肌萎缩侧索硬化症患者在发病2-5年内死亡。我们最近发现了导致肌萎缩侧索硬化症的基因TDP-43和FUS的突变。我们的目标是开发出携带这些突变的鱼类。我们将对这种鱼进行监测和测试，以确定它们是否会出现类似于ALS的症状和特征。如果是这样的话，这种新的鱼类模型将可用于研究疾病的生物学和评估治疗方法。

Amyotrophic lateral sclerosis (ALS) causes the progressive death of motor nerves. Most ALS patients die within 2-5 years of disease onset. We recently identified mutations that cause ALS in the genes TDP-43 and FUS. We aim to develop fish that carry these mutations. We will monitor and test this fish to establish whether they develop similar symptoms and features to ALS. If so, this new fish model will be available for investigating the biology of the disease and for evaluating treatments