Midcareer Mentoring Award for Patient-Oriented Research in Aging

项目摘要/摘要 这项建议的目的是(1)使应聘者能够进一步发展她的研究计划 关于改进老年人癌症筛查和预防的研究和(2)利用她的研究计划作为 指导对老龄化研究感兴趣的以患者为导向的初级调查人员的平台 老年病学和医学子专科。候选人是一位老年病学家，他已经建立了一个 高影响力的独立临床研究计划，资金充足，有出色的出版物 唱片。在完成老年医学研究后的10年里，她已经确立了自己的地位 成功地指导发表了高影响力老龄化研究的学生、研究员和初级教职员工， 获得成功资助，并继续参与以患者为中心的老龄化研究。 候选人已经开发了广泛的研究组合，专注于癌症筛查的结果 在寻求通过更好地定义风险和改善癌症筛查目标的老年人中 福利，特别是作为预期寿命的函数。这项工作影响了美国国家卫生研究院的筛查指南 他们利用这项研究建议筛查决定更多地关注预期寿命 而不是按年龄排序，并更好地认识到筛查的潜在危害。这项提议将提供 候选人有受保护的时间将她的研究扩展到一个新的方向，专注于 老年癌症幸存者的癌症复发。对老年癌症幸存者的监测提出了类似的问题 筛查，因为它可以通过发现仍可治疗的复发癌症而潜在地使老年人受益，但也 可能会通过过度治疗而导致严重的发病率。本提案中的研究将为决策提供参考 通过更好地确定老年前列腺癌监测检测的风险和好处，在这一领域取得进展 幸存者。这一新方向保持了她的研究重点，同时与肿瘤学建立了新的合作关系。 应聘者还将制定正式的指导计划，包括招聘、选拔、 对将成为老龄化研究领导者的受训者进行开发和评估。每个学员都将 有一个有重点的职业发展计划，其中他们完成研究项目并发展技能 在老龄化研究中需要成为独立的调查者。这项提议整合了候选人的 加州大学旧金山分校卓越的临床研究培训环境中的指导计划，利用HER 老年医学部和临床与翻译科学研究所(CTSI)的领导职位 职业发展(KL2学者)计划招募更多对老龄化研究感兴趣的导师。

PROJECT SUMMARY/ABSTRACT The aims of this proposal are to (1) enable the candidate to further develop her research program focused on improving cancer screening and prevention in older adults and (2) use her research program as a platform for mentoring junior patient-oriented investigators interested in aging research, both within Geriatrics and within the medical subspecialties. The candidate is a Geriatrician who has established a high-impact independent clinical research program that is well funded with an outstanding publication record. In the 10 years since completing her Geriatrics fellowship she has established herself as a successful mentor of students, fellows, and junior faculty who have published high-impact aging research, become successfully funded, and continue to participate in patient-oriented research in aging. The candidate has developed an extensive research portfolio focused on the outcomes of cancer screening in elders that has sought to improve the targeting of cancer screening by better defining the risks and benefits, particularly as a function of life expectancy. This work has influenced screening guidelines in the U.S., which have used this research to recommend that screening decisions focus more on life expectancy than chronological age and better recognize the potential harms of screening. This proposal will provide the candidate with protected time to expand her research in a new direction focused on surveillance testing for cancer recurrence in older cancer survivors. Surveillance in older cancer survivors poses similar issues to screening in that it can potentially benefit elders by finding recurrent cancers when still treatable but also may cause substantial morbidity through overtreatment. The research in this proposal will inform decision making in this area by better defining the risks and benefits of surveillance testing in older prostate cancer survivors. This new direction maintains her research focus while building new collaborations with oncology. The candidate will also develop a formal mentoring program with plans for the recruitment, selection, development, and evaluation of mentees who will become leaders in aging research. Each mentee will have a focused career development plan in which they complete research projects and develop the skills needed to become independent investigators in aging research. This proposal integrates the candidate's mentoring program into the outstanding clinical research training environment at UCSF, leveraging her leadership positions in the Division of Geriatrics and the Clinical and Translational Science Institute (CTSI) Career Development (KL2 Scholars) Program to recruit more mentees interested in aging research.