The Use of Novel Technologies to Investigate Bone Health in Diabetes Mellitus

阿尔马斯博士花了相当长的时间发展她的研究和职业生涯，完成了 临床内分泌学奖学金，成为美国内科委员会内分泌学认证， 糖尿病和新陈代谢，以及完成、提交和发表临床研究项目。她长长的- 学期目标是成为一名学术内科医生-科学家，在以下领域进行临床翻译研究 并精通最先进的骨骼分析方法。这项导师K奖包括 公共卫生硕士，专攻生物统计学和流行病学。它还专注于 骨研究领域所需的技术技能，包括临床骨活检程序的培训， 组织形态计量学、微型计算机断层扫描(Micro-CT)和外周定量计算机 体层摄影(PQCT)。 克雷顿大学骨质疏松症研究中心是一个独特的研究骨骼的地方，有超过45年的历史 临床研究经验。罗伯特·R·雷克博士在进一步研究骨骼方面发挥了重要作用。 菲尔德。在研究领域建立学术生涯所需的技能和知识正在被用于 这一天，研究中心内和附属于该中心的数十人。 这个有指导的研究项目旨在使用统计设计的技术技能和知识 并将其研究并应用于糖尿病患者的骨病问题。这是一个前瞻性的， 应用DXA、骨标记物、pQCT、组织形态计量学和显微CT对糖尿病患者进行的病例对照研究 暂时性骨活组织检查。这项人体研究旨在阐明1型糖尿病对1)的影响 骨重建，包括骨形成和吸收的组织形态计量学和生化测量， 2)在结构上，包括骨小梁的微结构排列和骨密度。 相关性(请参阅说明)： 糖尿病患者的骨折发生率高于普通人群。其机制尚不确定。的研究 人的骨量和大鼠。糖尿病模型表明骨骼转换减少，导致脆性和 骨折。这在人类身上还没有表现出来。这将是对人类糖尿病骨病的第一次研究。 采用组织形态计量学、显微CT和pQCT等手段阐明骨脆性的发生机制。这将导致 糖尿病患者骨病防治的进一步研究。

Dr, Armas has spent considerable time developing her research and professional career by completing a clinical endocrinology fellowship, becoming American Board of Internal Medicine certified in Endocrinology, Diabetes and Metabolism, and completing, presenting and publishing clinical research projects. Her long- term goals are to be an academic physician-scientist conducting clinical translational research in the field of bone disease and to be expert in state-of-the-art methods of bone analysis. This mentored K award includes a Masters of Public Health with a concentration in biostatistics and epidemiology. It is also focused on the technological skills needed in the bone research field, including training in transilial bone biopsy procedure, histomorphometry, micro-computed tomography (micro-CT), and peripheral quantitative computed tomography (pQCT). Creighton University Osteoporosis Research Center is a unique place to study bone with over 45 years of clinical research experience. Dr. Robert R. Recker has been instrumental in furthering research in the bone field. The skills and and knowledge needed to build an academic career in research are being used every day by dozens of people in and affiliated with the research center. This mentored research project is designed to use the technological skills and knowledge of statistical design and research and apply them to the problem of bone disease in patients with diabetes. This is a prospective, case-control study of diabetic subjects using DXA, bone markers, pQCT, histomorphometry, and micro-CT of transilial bone biopsies. This human study is designed to elucidate the effect of Type 1 diabetes on 1) bone remodeling, including histomorphometric and biochemical measures of bone formation and resorption, and 2) on structure, including micro-architectural arrangement of trabeculae and bone mineral density. RELEVANCE (See Instructions): Diabetics have higher rates of fracture than the general population. The mechanism is uncertain. Studies of human bone mass and rat. models of diabetes point to reduced bone turnover that leads to fragility and fractures. This has not been shown in humans. This will be the first study in humans of diabetic bone disease using histomorphometry, micro-CT and pQCT to elucidate the mechanisms of bone fragility. This will lead to further research in prevention and treatment of bone disease in patients with diabetes.