Rocky Mountain Neurological Disorders Core

线人。1.基本原理。光学显微镜核心(LMC；见www.uchsc.edu/liqhtmicroscope)已被证明是一种 高度有用、成功的多用户(共42台，见附录第4项)设施提供5台最先进的仪器。新技术不断涌现，我们有一个令人兴奋的机会，通过新的先进仪器和技术专业知识将LMC的规模扩大近一倍。我们建议与医学部肾科的一个设施合并，该设施由Mohe Levi博士(医学、生理学和生物物理学教授；医学研究副主席)开发。直到最近，这两个设施在仪器、空间、用户、管理和资金方面都是完全分开的。这种情况的出现是因为健康科学中心建造了一个耗资22亿美元的全新园区，并将其搬迁到了一个全新的园区。这一举动发生在大约六年的时间里，于2009年1月完成。LMC是最早采取行动的机构之一，而核心医学部是最后采取行动的机构之一。因此，在大约五年的时间里，这两个核心 完全独立运作。现在他们在同一个校园里(在由加热桥连接的相邻建筑中)，我们有机会将它们结合在一起，并向RMNDC用户提供新的仪器，而不需要额外的设备。此外，全校五年一度的研究务虚会定于2009年11月举行，光学显微镜已被中央行政当局选为一体 确定了需要特别考虑的三个领域。可能的结果将是医学院在新的合并核心中投入大量内部资金。贝茨博士和利维博士是负责在务虚会上提交长期计划的委员会的联合主席。虽然仍处于规划阶段，但一个主要目标是 购买新的先进仪器。他的委员会已经确定了多个用户感兴趣的几种仪器(例如，具有微透镜照明的先进旋转圆盘显微镜、受激发射耗尽(STED)显微镜)。

CI. 1 Rationale. The Light Microscopy Core (LMC; see www.uchsc.edu/liqhtmicroscopv) has proven to be a highly useful, successful multi-user (42 total, see Appendix Item 4) facility offering five state-of-the-art instruments. New technologies continually emerge, and we have an exciting opportunity nearly to double the size of the LMC with new, advanced instrumentation and technical expertise. We propose to combine with a facility in the Renal Division of the Department of Medicine, which has been developed by Dr. Moshe Levi (Professor of Medicine, Physiology and Biophysics; Vice Chair of Medicine for Research). Until recently, the two facilities were entirely separate, in terms of instrumentation, space, users, administration, and funding. This situation arose because the Health Sciences Center built and moved to an entirely new $2.2B campus. The move occurred over about six years and was completed in January 2009. The LMC was one of the first to move, while the Department of Medicine Core was one of the last. Thus, for about five years the two cores operated entirely independently. Now that they are on the same campus (in adjacent buildings connected by a heated bridge), we have an opportunity to combine them, and make available to RMNDC users new instruments, at no additional chiarge to them. In addition, a campus-wide quinquennial Research Retreat is scheduled for November, 2009, and Light Microscopy has been selected by the central administration as one of three areas identified for special consideration. The likely upshot will be significant investment of intramural funds by the School of Medicine in the new, combined core. Dr. Betz is co-chair with Dr. Levi of the committee charged with presenting a long range plan at the Retreat. While still in the planning stages, a major goal is the purchase of new advanced instruments. Already his committee has identified several instruments of interest to multiple users (e.g., advanced spinning disk microscope with microlens illumination, STimulated Emission Depletion (STED) microscope).