Infection and Immunity K-12 Science Program: Exploring Knowns/Unknowns via VCRC/Q

描述(由申请者提供)：提高健康/科学素养是国家健康/教育议程的首要任务，与NIH-NIAID的战略相结合，以激励临床研究事业，增强公众对科学[特别是~感染(In)和免疫(IM)]的理解，并加快将发现转化为实践。这份R25提案来自经验丰富的团队，由经验丰富的临床医生和科学家领导，致力于针对不同/弱势的K-16和健康专业学生的以结果为导向的教育干预措施，建立在人员、项目和合作伙伴以及学生“网络素养”的国家基础设施之上。利用我们于2011年推出的基于网络的虚拟临床研究中心和问答空间(VCRC/Q)，具体目标是：1)连接、定制和扩展这一独特的一站式“学习网格”(用于整合和个性化特定领域的内容、学习活动和用户服务)，以提供新的In/IM课程，并在生物医学世界、K-12学校和普通公众之间提供最先进的多方面双向联系；2)开发一种新的以探究为导向、以学生为中心的多媒体K-12核心课程--“感染与免疫：已知和未知(答案！和问题？)”。(在K！/U中？)在K！/U中？针对亚利桑那州不同的/处境不利的高中生，然后年龄适应K-8，在VCRC/Q或面对面的教室，实验室和家庭使用。它介绍了医学的“语言”(词汇)，并重点介绍了与NIAID相关的基础、临床和翻译研究主题、工具和科学家榜样，将不同的专家和多层次的学生混合在一起作为演讲者/制作人。创新的主题和学习策略交织着生物医学的《知识》(今日知/答！)和“无知”(未知/问题？-未来的学习和发现)，反映真实的科学，鼓励学生在VCRC/Q、教室/学校实验室和家里提出自己的问题和探索答案。在K9-12和K-8级别的动画引子/快照形式介绍的主题中，将包括：病理生物学(炎症、坏死、免疫和肿瘤)的入门概述；研究工具；细菌、真菌和病毒生物；感染包括结核病、性传播疾病、球孢子菌病、艾滋病、流感；耐甲氧西林金黄色葡萄球菌，伤口/外科感染；来自蠕虫和昆虫媒介的寄生虫病；1和2免疫疾病、器官移植、疫苗和生物恐怖主义；3)通过系列互动多媒体教师工作坊、全年在职咨询和在线社交网络，提供K-12教师培训和支持，以鼓励教师和学生自主/反映国家/国家标准的创新。综合形成性/总结性评估包括3个阶段(设计、实施、传播)和对项目和教师/学生参与者结果的短期和长期评估，包括作为“提问者”。VCRC/Q的国家/国际传播中心正在扩大多媒体、多学科、多机构伙伴关系和社会网络，以提高影响力。

DESCRIPTION (provided by applicant): Improvement in health/science literacy tops the nation's health/education agenda, meshing with NIH-NIAID's strategies to energize the clinical research enterprise, enhance public understanding of science [specifically ~ Infection (In) and Immunity (Im)], and expedite translation of discovery into practice. This R25 proposal, from an experienced team led by accomplished clinician-scientists devoted to outcomes-oriented educational interventions targeting diverse/disadvantaged K-16 and health professional students, builds on a national infrastructure of people, programs, and partnerships as well as student "cyberliteracy". Using our web-based Virtual Clinical Research Center and Questionarium (an interactive Questioning Space)(VCRC/Q) launched in 2011, specific aims are: 1) connect, customize, and scale this unique one stop "learning grid" (for integrating and personalizing domain-specific content, learning activities, and user services) to deliver a new In/Im curriculum and provide state-of-the-art multifaceted bidirectional linkage between the biomedical world and K-12 schools and general public; 2) develop a new inquiry-driven student-centered multimedia K-12 core curriculum - "Infection and Immunity: Knowns and Unknowns (Answers! and Questions?)" (InIm K!/U?). InIm K!/U? targets diverse/disadvantaged Arizona high school students, then age-adapted for K-8, on VCRC/Q or face-to-face for classroom, laboratory, and home use. It introduces the "language" (vocabulary) of medicine and highlights the spectrum of NIAID-related basic, clinical, and translational research topics, tools, and scientist role models mixing diverse experts and multilevel students as presenters/ producers. The innovative theme and learning strategy interweaves biomedical "Knowledge" (today's Knowns/Answers!) and "Ignorance" (Unknowns/Questions? - future learning and discovery), mirroring authentic science and encouraging students to ask their own questions and explore answers in VCRC/Q, classrooms/school labs, and home. Among topics introduced in animated graphically attractive teaser/snapshot form at the K9-12 then K-8 level will be: introductory mini-overview of pathobiology (inflammation, necrosis, immunity and neoplasia); research tools; bacterial, fungal, and viral organisms; infections including tuberculosis, sexually transmitted diseases, coccidioidomycosis, AIDS, influenza; MRSA, wound/surgical infections; parasitic diseases from worms and insect vectors; 1 and 2 immune disorders, organ transplantation; vaccines; and bioterrorism; 3) provide K-12 teacher training and support through serial interactive multimedia teacher workshops, year round inservice consultation, and online social networking to encourage teacher and student ownership/innovation reflecting state/national standards. Comprehensive formative/summative evaluation includes 3-phases (design, implement, disseminate) and short- and long-term assessment of program and teacher/student participant outcomes including as "questioners". National/ international dissemination centers in VCRC/Q's expanding multimedia, multidisciplinary, multi-institutional partnerships and social networking to enhance impact.