toxic and carcinogenic potential of alpha-pinene in laboratory animals for the National Toxicology Program (NTP)
toxic and carcinogenic potential of alpha-pinene in laboratory animals for the National Toxicology Program (NTP)
批准号:
8948077
负责人:
MILTON D HEJTMANCIK
金额:
$107.83万
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-04-15 至 2015-04-14
关键词:
AnimalsBreathingChemicalsChemistryChronicEngineeringFertilityFlavoringGoalsHumanInhalation ExposureLaboratory AnimalsMusNational Toxicology ProgramPhaseProcessRattusSelf CareSperm Count ProcedureSperm MotilitySystemToxic effectToxicity TestsTurpentinealpha-pinenecarcinogenicityhazardmalereproductive
中文摘要
该项目的目标是评估大鼠和小鼠全身吸入后α-蒎烯的慢性毒性和致癌性。α-蒎烯存在于松节油、调味品和香水中。人类可能通过使用个人护理和清洁产品以及在木材加工和建筑活动中暴露。为期两年的α-蒎烯慢性毒性和致癌性研究正处于化学和吸入暴露系统工程阶段。这些研究包括对生育力、精子数量和活动率的评估,因为男性生殖影响是预期的。
关键词:毒性、致癌性、吸入、α-蒎烯
英文摘要
The goal of this project is to evaluate the chronic toxicity and carcinogenicity of alpha-pinene in rats and mice, following whole body inhalation exposure. Alpha-pinene is found in turpentine and in flavorings and fragrances. Humans may be exposed through use of personal care and cleaning products as well as in lumber processing and building activities. 2-Year chronic toxicity and carcinogenicity studies of alpha-pinene are in the chemistry and inhalation exposure system engineering phase phase. These studies include an assessment of fertility and sperm count and motility, as male reproductive effects are anticipated.
Keywords: toxicity, carcinogenicity, inhalation, alpha-pinene
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