Infectious Diseases Training Program

描述(申请人提供)：传染病仍然是对人类最重要的全球健康威胁；然而，正在接受培训的内科科学家数量不足，他们正在为可能影响我们对传染病发病机制和治疗的理解的学术研究职业做准备。我们建议继续开展德克萨斯大学西南分校传染病博士后培训计划，以培训医生-科学家进行与宿主-病原体相互作用相关的尖端基础科学研究。该计划为成人和儿童传染病研究员(以及对宿主-病原体相互作用感兴趣的肺、消化和肝脏研究员)提供培训。该计划的总体目标是培养内科科学家，以便在与传染病相关的学术研究中取得成功。研究培训的具体目标是为学员：(1)熟练掌握与宿主-病原体相互作用领域的传染病研究相关的最新技术；(2)获得生物医学相关领域的专业知识，如微生物遗传学、免疫学、细胞生物学、生物化学或药理学；(3)在生成强有力的研究假设以及严格的实验设计和数据解释方面获得专业知识和独立性；以及(4)完成一项指导研究项目，导致一份或多份同行评议的首创出版物和NIH职业发展奖申请。这些目标将通过(1)在我们22个项目培训教师(他们都是由NIH资助的杰出科学家在宿主-病原体相互作用领域进行激动人心的工作)实验室的密集监督基础科学研究经验；(2)包括生物医学科学、伦理学、统计学和职业发展方面的必修课和选修课的综合教学课程；(3)主要导师和论文委员会成员的积极指导和职业发展；以及(4)有机会在高度互动和刺激的跨学科科学环境中进行培训。这种全面和多方面的方法将导致对传染病研究方面的博士后研究员进行培训，这些研究员具有在学术研究事业中取得成功的强大潜力，并具有开展将对预防和/或治疗传染病产生影响的基础科学研究的强大潜力。

DESCRIPTION (provided by applicant): Infectious diseases continue to represent the most important global health threat to mankind; yet inadequate numbers of physician-scientists are being trained who are prepared for academic research careers that can impact our understanding of the pathogenesis and treatment of infectious diseases. We propose the continuation of the UT Southwestern (UTSW) Infectious Diseases postdoctoral training program to train physician-scientists to perform cutting edge basic science research related to host-pathogen interactions. This program provides training for Adult and Pediatric Infectious Diseases Fellows (as well as Pulmonary and Digestive and Liver Fellows who are interested in host-pathogen interactions). The overall goal of this program is to train physician-scientists for successful careers in academic infectious diseases-related research. Specific goals of the research training are for trainees to: (1) develop proficiency in state-of-the art- techniques relevant to infectious diseases research in the area of host-pathogen interactions; (2) gain expertise in a relevant area of biomedical science, such a microbial genetics, immunology, cell biology, biochemistry, or pharmacology; (3) gain expertise and independence in generating strong research hypotheses and in rigorous experimental design and data interpretation; and (4) complete a mentored research project that leads to one or more first-authored peer reviewed publications and NIH career development award applications. These goals will be accomplished by a combination of (1) intensive supervised basic science research experience in the laboratories of our 22 program training faculty (all of whom are outstanding NIH-funded scientists performing exciting work in the field of host-pathogen interactions); (2) a comprehensive didactic curriculum that includes required courses and electives in biomedical sciences, ethics, statistics, and career development; (3) active mentoring and career development by the primary mentor and thesis committee members; and (4) the opportunity to train in a highly interactive and stimulating interdisciplinary scientific environment. This comprehensive and multi-faceted approach will result in the training of post-doctoral fellows in Infectious Diseases research with strong potential to succeed in academic research careers and strong potential to perform basic science research that will impact the prevention and/or treatment of infectious diseases.