Core Center for Musculoskeletal Biology and Medicine

描述(由申请人提供)：在过去的四年里，借助P30 CCMBM拨款，我们松散的肌肉骨骼实验室已经发展成为一个备受尊敬的肌肉骨骼研究中心，拥有来自22个部门的75名成员，发表了250多篇论文(记者提供158篇)，一个新的设施，拥有12个与政府和研究核心共同定位的肌肉骨骼实验室，一个积极和富有成效的试点和可行性计划，一个广受欢迎的肌肉骨骼研讨会系列和出席人数众多的年度研讨会。我们感兴趣的领域涵盖了各种各样的常见肌肉骨骼疾病，从骨质疏松症到骨关节炎，再到肌腱损伤到癌症。我们现在有5900万美元的资金，其中3500万美元来自NIH，最近还获得了骨骼代谢疾病T32培训补助金。在接下来的五年里，我们计划将我们的中心扩大到包括我们更大、更多样化的研究基础所产生的更广泛的研究兴趣，例如癌症到骨的转移、脊柱侧弯和椎间盘疾病、肌腱到骨的愈合、软骨修复和再生医学中的干细胞。我们的丰富计划将扩大到包括指导活动和专门研究技术的培训和教育。CCMBM提供了许多新的服务，这些服务将有助于推动研究基础的科学化，例如扩大动物模型以包括斑马鱼，使用组织学分离特定群体的细胞，以及监测组织质量的新的非侵入性技术。我们的研究核心是：核心B：肌肉骨骼结构和强度，核心C：组织学和形态计量学，核心D：动物模型。在ICTS的帮助下，我们非常兴奋地加入了将我们的动物研究翻译给患者的新重点。CCMBM将继续在促进高质量研究方面发挥领导作用，促进合作和跨学科方法，扩大研究基地的队伍，并通过我们的研究核心提供越来越复杂和强大的技术，帮助推动肌肉骨骼研究人员的科学发展。

DESCRIPTION (provided by applicant): Over the past four years with the opportunity provided by the P30 CCMBM grant, our loosely organized set of musculoskeletal labs has developed into a well-respected Musculoskeletal Research Center with 75 members from 22 Departments, over 250 publications (158 in Reporter), a new facility with 12 musculoskeletal labs co-localized with the Administration and Research Cores, an active and productive Pilot and Feasibility Program, a popular Musculoskeletal Seminar Series and well-attended Annual Symposia. Our fields of interest have covered a wide variety of common musculoskeletal disorders from osteoporosis to osteoarthritis to tendon injuries to cancer. We now have $59 million in funding with $35 million from the NIH, and were recently awarded a T32 Training grant in Skeletal Metabolic Diseases. During the next five years, we plan to grow our Center to include a wider range of research interests stemming from our larger and more diverse research base, such as cancer metastasis to bone, scoliosis and intervertebral disc disease, tendon to bone healing, cartilage repair and stem cells in regenerative medicine. Our enrichment program will be expanded to include mentoring activities and training and education in specialized research techniques. The CCMBM enables the offering of many new services that will help drive the science of the research base, such as an expansion of the animal models to include zebrafish, isolation of specific populations of cells using histology and new non-invasive techniques to monitor tissue quality. Our Research Cores are: Core B: Musculoskeletal Structure and Strength, Core C: Histology and Morphometry, and Core D: Animal Models. With the help of the ICTS, we are very excited to include a new emphasis on translation of our animal research to the patient. The CCMBM will continue to provide leadership in promoting quality research, foster collaborations and interdisciplinary approaches, expand the ranks of the research base and help drive the science of musculoskeletal investigators by providing increasingly sophisticated and powerful technologies through our research cores.