Multidisciplinary Training in Brain Disorders and Development

描述（由申请人提供）：该博士后培养计划的目标是培养年轻科学家，并促进专注于理解和开发发育性脑疾病治疗的职业发展。计划在与神经发育障碍研究相关的科学学科中进行多学科培训。因此，从4个系选出了23名培训教员。他们包括：3名博士，7名博士/博士和13名博士。现有教授12人，副教授5人，助理教授6人。现有博士后95人，其中博士/博士7人，博士11人，博士77人。John Swann博士将继续担任项目总监，并负责项目的日常运作。Drs。胡达·佐格比和杰夫·诺贝尔斯将继续担任联合董事。主要培训领域包括神经发育障碍的遗传和分子基础，包括但不限于：Rett综合征，Angelman综合征，脆性X染色体综合征和自闭症。另一个集中的训练领域是癫痫，研究遗传和获得性癫痫的分子基础。所有实验室都采用尖端的生物技术来创建和研究疾病的相关动物模型，不仅是为了了解这些疾病的生物学基础，而且是为了筛选可能导致临床试验并最终进入临床实践的潜在新疗法。在过去几年的支持下，迄今已有24名博士后进入我们的培训计划，8名已在主要大学担任教职。其中包括4名医学博士/博士儿童神经学家，他们已经获得了K08资助，现在正在从事研究工作。提供三个培训课程。一种是具有丰富研究经验的医学博士/博士和医学博士。另一种是针对经验不足的医学博士，培训更为正式，包括实验室轮岗和研究生课程。博士们通过晚餐讨论、临床会议和亚专科诊所接受神经发育障碍临床方面的大量培训。简和丹·邓肯神经学研究所（NRI）的成立是德克萨斯儿童医院和贝勒医学院致力于研究发育障碍的神经生物学的最新和最引人注目的证明。这个培训项目现在设在NRI，它有望成为研究和培训发育性大脑异常的主要中心。通过培养杰出的研究科学家，我们感到对婴幼儿毁灭性神经系统疾病的新认识和新治疗方法将会出现。

DESCRIPTION (provided by applicant): The goal of this postdoctoral training program is to train young scientists and promote careers focused on understanding and developing treatments for developmental brain disorders. Multidisciplinary training is planned in scientific disciplines relevant to the study of neurodevelopmental disorders. Thus, 23 training faculty have been selected from 4 departments. They include: 3 MDs, 7 MD/PhDs and 13 PhDs. There are: 12 Professors, 5 Associate Professors and 6 Assistant Professors. There are currently 95 postdoctoral students training in laboratories of the faculty and include 7 MD/PhDs, 11 MDs and 77 PhDs. Dr. John Swann will continue to serve as the Program Director and will be responsible for the day-to-day operation of the program. Drs. Huda Zoghbi and Jeff Noebels will continue to serve as co-directors. Major areas of training include the genetic and molecular basis of neurodevelopmental disorders including but not limited to: Rett syndrome, Angelman syndrome, Fragile X syndrome and Autism. Another concentrated area of training is in epilepsy where the molecular bases of the inherited as well as acquired epilepsies are studied. All labs employ cutting edge biotechnology to create and study relevant animals models of disease in order to not only understand the biological basis for these disorders but to screen potential new therapies that could lead to clinical trials and eventually enter clinical practice. Over the past years of support, 24 postdoctoral students have thus far entered our training program and 8 have accepted faculty positions at major universities. These include 4 MD/PhD child neurologists that have been awarded K08 grants and are now pursuing research careers. Three training tracks are offered. One is for MD/PhDs and MDs with substantial research experience. Another is for less experienced MDs where training is more formal and includes laboratory rotations and graduate courses. PhDs receive substantial training in clinical aspects of neurodevelopmental disorders through dinner discussions, clinical conferences and subspecialty clinics. The opening of the Jan and Dan Duncan Neurological Research Institute (The NRI) is the most recent and dramatic demonstration of the commitment of Texas Children's Hospital and Baylor College of Medicine to the study of the neurobiology of developmental disorders. This training program is now based in the NRI, which promises to become a major center for the study of and training in developmental brain abnormalities. By training outstanding research scientists, we feel new understandings and treatments for the devastating neurological disorders of infants and young children will emerge.