Predoctoral Training in Molecular Biophysics

描述（由申请人提供）：本更新提案寻求继续支持国立卫生研究院/科罗拉多大学博尔德分校分子生物物理学博士前培训计划。这个9年的计划的目标是准备卓越的，高度积极的生物物理学学生生产性的研究事业。37名培训教师是一支杰出的，国际公认的研究小组，来自四个部门：化学与生物化学；分子、细胞和发育生物学；化学与生物工程;和物理。这些教师和他们的学生一起，使用最先进的生物物理方法来阐明大分子结构、动力学、机制和功能的基本方面，从单分子到复杂的多组分组合。其中许多项目侧重于与人类健康和疾病直接相关的问题。分子生物物理学是博尔德校区发展最快的研究领域。在过去的十年里，37名培训教员中有20人来到了博尔德。这一增长背后的重要推动力是由NIH和大学基金共同支持的NIH/CU分子生物物理学培训计划。该培训项目在不同实验室和部门的生物物理学家之间建立了一个蓬勃发展的生物物理学社区。此外，该项目为生物物理学的博士生提供严格的培训，确保这些学生获得开展前沿生物物理学研究所需的广泛的跨学科基础。必修课程包括专门为该计划开发的生物物理学课程和负责任的研究行为课程。第一年的培训包括课程作业、实验室轮岗和教学任务。在第二年的培训包括额外的课程和答辩计划的论文项目在口头博士候选人考试。第二年之后，学生每年与一个教师委员会会面，该委员会就他们的论文研究提供独立的反馈。在所有的培训年，定期的生物物理研讨会和超级小组会议鼓励生物物理学生，教师和实验室之间强有力的沟通和合作。在当前的资助期内，培训项目在多个方面都取得了巨大的进步，这证明了1)增加了令人兴奋的新教员，2)招募了越来越多的高素质、合格的学生到成员部门，3)增加了本科生的参与，4)增加了未被充分代表的群体的参与和毕业，5)培训方面的创新，6)学员的出版、毕业和博士后入学率很高。7)培训实验室之间大量的合作出版物。

DESCRIPTION (provided by applicant): This renewal proposal seeks continuing support for the NIH/CU Molecular Biophysics Predoctoral Training Program at the University of Colorado, Boulder. The goal of this nine-year old program is to prepare exceptional, highly motivated biophysics students for productive research careers. The thirty- seven training faculty are an outstanding, internationally recognized group of investigators from four departments: Chemistry & Biochemistry; Molecular, Cellular & Developmental Biology; Chemical & Biological Engineering; and Physics. These faculty, together with their students, are using state-of-the- art biophysical methods to elucidate fundamental aspects of macromolecular structure, dynamics, mechanism, and function in systems ranging from single molecules to complex, multi-component assemblies. Many of these projects focus on questions of direct relevance to human health and disease. Molecular Biophysics is the most rapidly growing research field on the Boulder campus. Twenty of the thirty-seven training faculty have arrived in Boulder within the last ten years. An important driving force behind this growth is the NIH/CU Molecular Biophysics Training Program, jointly supported by NIH and University funds. The training program has established a thriving biophysical community with extensive collaborations among biophysicists in different laboratories and departments. Moreover, the program provides rigorous training for predoctoral students of biophysics, ensuring that such students receive the broad, interdisciplinary foundation needed to carry out cutting edge biophysical research. Required coursework includes biophysical courses developed specifically for the program and a Responsible Conduct of Research course. Training during the first year includes coursework, laboratory rotations, and teaching duties. Training during the second year includes additional coursework and defense of the planned thesis project in an oral PhD candidacy exam. Following the second year, students meet yearly with a faculty committee that provides independent feedback on their thesis research. In all training years, regular Biophysics Seminars and Super group meetings encourage strong communication and collaboration between biophysical students, faculty, and laboratories. During the current funding period, the training program has exhibited strong progress in multiple dimensions as evidenced by 1) addition of exciting new faculty, 2) recruitment of growing numbers of high quality, eligible students to the member departments, 3) increased participation by matriculates, 4) increased participation and graduation of underrepresented groups, 5) innovations in training, 6) strong publication, graduation, and postdoctoral entrance rates of trainees, and 7) large numbers of collaborative publications between training laboratories.