Chemistry-Biology Interface Training Grant

描述(由申请者提供)：这个令人兴奋的化学-生物接口博士前培训项目涉及来自明尼苏达大学三个系的31名培训人员：化学、药物化学和生物化学、分子生物学和生物物理学(BMBB)。明尼苏达大学CBITG的使命是为不同类型的学生提供跨越传统界限所需的技能，理解并开展化学和生物领域的科学研究。这项任务将通过实现以下目标来完成：(I)通过至少两个系的课程，通过有一名辅导员参与的交叉培训经验和在辅导员实验室三个月的研究经验相结合的方式，为学生提供化学和生物相结合的跨学科培训经验。(Ii)通过侧重于这类界面科学的研讨会(化学生物学讨论会)，让学生接触化学和生物界面的尖端科学，并允许他们组织自己的以化学生物界面为重点的研讨会。(3)加强受训人员的交流技能，为他们提供多种机会介绍他们的研究成果，包括在国家或国际会议上作介绍。(4)教育学生了解接受过该领域培训的科学家可获得的各种职业机会。(V)通过对受训者、培训员和在化学/生物界面工作的著名科学家的访谈，激发人们对我们的培训方案的兴趣。(6)增加从事研究的科学家的多样性 化学和生物在我们的项目中通过不同的外展活动相结合。学员将参与的研究主题包括：生物催化和生物分子设计(Distefano、Kazlauskas、Lipscomb、Ohlendorf、Schmidt-Dannert、Seelig Wackett、Wagner、Wilmot)、治疗药物(Aldrich、Amin、Bernlohr、Distefano、Georg、Harki、Haskell-Luevano、Hoye、Mansky、Tretyakova、Wagner、Wilmot)、疾病化学(Aldrich、Arriaga、Bernlohr、Distemerfano、Harki、Haskell-Luevano、Mansky、Murphy、Pallantz、Tretyakova、Wagner、Xing)、生物化学(Amin、Lipsb、Murphy、Ohlendorf、Pierre、Arriaga、Wackett、Wilmot)和生物/生物分析(Aragria、Grin、Piffer、Piffer、Tretyakova、Thomas、Veglia)。培训教员的研究小组都得到了很好的支持和装备。这一非常成功的培训计划已经进行了14年。在此期间，该方案每年向8名受训人员提供支助，每名受训人员提供为期两年的支助。

DESCRIPTION (provided by applicant): This exciting pre-doctoral training program at the Chemistry-Biology Interface involves 31 training faculty from three departments at the University of Minnesota: Chemistry, Medicinal Chemistry, and Biochemistry, Molecular Biology and Biophysics (BMBB). The mission of the CBITG at the University of Minnesota is to provide a diverse cadre of students with the skills necessary to cross traditional boundaries and understand and conduct scientific research at the interface of chemistry and biology. This mission will be accomplished by achieving the following objectives: (i) Provide students with an interdisciplinary training experience at the interface of chemistry and biology through a combination of coursework involving classes from at least two departments and by a cross-training experience involving a coadvisor and a research experience of three months in the coadvisor's laboratory. (ii) Expose students to cutting-edge science at the interface of chemistry and biology through seminars focused on this type of interfacial science (Chemical Biology Colloquium) and by allowing them to organize their own symposium focused on the chemical biology interface. (iii) Enhance the communication skills of trainees by providing them with multiple opportunities to present their research including a presentation at a national or international conference. (iv) Educate students about the range of career opportunities available for scientists with training in this area. (v) Stimulate interest in our training program through te use of interviews with trainees, trainers and prominent scientists working at the chemistry/biology interface. (vi) Increase the diversity of scientists carrying out research at the chemistry and biology interface in our program through a combination of different outreach activities. Trainees will be involved in research themes that include: Biocatalysis and Biomolecular Design (Distefano, Kazlauskas, Lipscomb, Ohlendorf, Schmidt-Dannert, Seelig Wackett, Wagner, Wilmot), Therapeutic Agents (Aldrich, Amin, Bernlohr, Distefano, Georg, Harki, Haskell-Luevano, Hoye, Mansky, Tretyakova, Wagner, Xing), Chemistry of Disease (Aldrich, Arriaga, Bernlohr, Distefano, Harki, Haskell-Luevano, Mansky, Murphy, Pomerantz, Tretyakova, Wagner, Xing), Metallobiochemistry (Amin, Lipscomb, Murphy, Ohlendorf, Pierre, Que, Wackett, Wilmot), and Bioanalytical/Biophysical (Arriaga, Bowser, Griffin, Haynes, Pierre, Pomerantz, Tretyakova, Thomas, Veglia). The research groups of the training faculty are all well supported and well equipped. This highly successful training program has been ongoing for 14 years. In this period, support is requested for 8 trainees each year of the program, each to be supported for a two-year period.