Neurobehavioral Assessment of Interpersonal Functioning in PTSD

描述（由申请人提供）： 摘要愤怒和攻击性是创伤后应激障碍（PTSD）治疗中严重且常见的并发症。现在许多研究表明，人际攻击和愤怒：i）与创伤后应激障碍密切相关（对于元分析，参见Orth & Wieland，2006）; ii）在患有与战斗有关的PTSD的个体中特别有害（Novaco & Chemtob，2002）;以及iii）有效治疗与战斗有关的PTSD的关键障碍（福布斯等人，2003;福布斯等人，2008年）。尽管愤怒和攻击性对患有创伤后应激障碍的退伍军人的生活产生了有害影响，尽管愤怒和攻击性对治疗和康复构成了障碍，但人们对创伤后应激障碍中人际攻击性的神经行为病理学或创伤后应激障碍个体更普遍地参与合作互动的能力知之甚少。拟议研究的广泛目标是解决这些问题。也就是说，我们试图确定客观的行为和神经指标的侵略，有助于受损的社会交往的个人与战斗相关的创伤后应激障碍。为了实现这一目标，拟议的项目旨在：7量化行为决策和相关的神经活动，在侵略性和非侵略性的人际交流退伍军人与创伤后应激障碍和战斗匹配的控制退伍军人。图7量化患有PTSD的退伍军人和战斗匹配的对照退伍军人在合作和非合作人际交流期间的行为决定和相关神经活动。 第7章探索创伤后应激障碍中攻击性和合作性的诊断差异是否与理解社交伙伴的想法和意图相关的神经结构功能减弱有关。与战斗相关的创伤后应激障碍的人际关系困难的客观神经行为措施的发展将有助于早期识别退伍军人需要治疗，并可能有助于设计和实施有针对性的治疗干预措施。

DESCRIPTION (provided by applicant): ABSTRACT Anger and aggression are serious and frequent complicating factors in the treatment of post-traumatic stress disorder (PTSD). A host of studies now demonstrate that interpersonal aggression and anger are: i) strongly associated with post-traumatic stress disorder (for meta-analysis, see Orth & Wieland, 2006); ii) particularly pernicious among individuals with combat-related PTSD (Novaco & Chemtob, 2002); and, iii) critical barriers to effective treatment in combat-related PTSD (Forbes et al., 2003; Forbes et al., 2008). Despite the detrimental impact that anger and aggression have on the lives of combat veterans with PTSD, and despite the barrier that anger and aggression pose to treatment and recovery, very little is understood about the neurobehavioral pathology underlying interpersonal aggression in PTSD, or the capacity of individuals with PTSD to engage in cooperative interactions more generally. The broad goal of the proposed research is to address these areas. That is, we seek to identify objective behavioral and neural metrics of aggression that contribute to impaired social interactions of individuals with combat- related PTSD. To achieve this goal, the proposed project seeks to: 7 Quantify behavioral decisions and associated neural activity during aggressive and non- aggressive interpersonal exchanges among veterans with PTSD and combat-matched control veterans. 7 Quantify behavioral decisions and associated neural activity during cooperative and non- cooperative interpersonal exchanges among veterans with PTSD and combat-matched control veterans. 7 Explore whether diagnostic differences in aggression and cooperation in PTSD are related to diminished function of neural structures associated with understanding the thoughts and intentions of social partners. The development of objective neurobehavioral measures of interpersonal difficulties associated with combat-related PTSD will facilitate early identification of veterans in need of treatment, and may aid in design and implementation of targeted therapeutic interventions.