Biostatistics Core

生物统计学共享资源（BioSR）的主要目标是促进以下方面的同行评审研究： 维克森林大学综合癌症中心（CCCWFU）成员。我们与 来自所有四个项目的成员（细胞生长和存活，临床研究，癌症预防和 控制和细胞损伤和防御）贯穿癌症相关研究项目的所有阶段。主要 负责方法、统计和计算机相关问题，包括研究 临床试验监查的设计、抽样、统计方面、中期审查和最终分析。 具体而言，BioSR支持以下五个领域：1）方案开发，即，发展中 适当的统计设计，编制统计部分，并审查所有统计内容 提交CCCWFU审查的方案; 2）方案监测，即，监测患者累积， 必要时进行中期分析; 3）统计分析和出版物，即，勾结 CCCWFU所有项目的研究人员提供数据统计分析和结果解释 协助发表研究结果; 4）新赠款开发，即，与CCCWFU研究人员会面， 讨论潜在赠款的设计和分析计划，并进行定期赠款援助 计划会议，与CCCWFU调查人员就潜在的赠款进行头脑风暴;以及5）领导和 培训，即，参加CCCWFU委员会，负责科学和行政决策 并为CCCWFU成员举办每月一次的研究方法专题系列研讨会。 BioSR是CCCWFU的高度利用和成本效益的资源。从2009年11月1日到10月。 2010年3月31日，BioSR为癌症相关工作提供了超过5,000小时的支持。在同一时间 在此期间，BioSR协助了来自所有项目的115名不同的研究人员（71名科学成员）， CCCWFU内的卓越中心。此外，20个由检察官发起的机构方案， 开放，监测了30份由检察官发起的机构协议，20份手稿（2010年） 在此期间，在生物科学报告的协助下，出版了30多份赠款。为即将到来的 赠款期间，我们要求总共2.45个全职员工的支持，分为统计，行政和 为提供这些持续服务提供方案支助。

The primary goal of the Biostatistics Shared Resource (BioSR) is to facilitate the peer-reviewed research of members of the Comprehensive Cancer Center at Wake Forest University (CCCWFU). We collaborate with members from all four programs (Cell Growth and Survival, Clinical Research, Cancer Prevention and Control, and Cellular Damage and Defense) throughout all phases of cancer-related research projects. Major responsibilities are assumed for methodological, statistical, and computer-related issues including study design, sampling, statistical aspects of clinical trial monitoring, interim reviews, and final analysis. Specifically, the BioSR supports the following five areas 1) Protocol Development, i.e., developing appropriate statistical designs, preparing statistical sections, and reviewing the statistical content of all protocols submitted for review at the CCCWFU; 2) Protocol Monitoring, i.e., monitoring patient accrual and performing interim analyses when needed; 3) Statistical Analyses and Publications, i.e., collaborating with CCCWFU investigators from all programs to provide statistical analyses of data and interpretations of results to assist in publications of findings; 4) New Grant Development, i.e., meeting with CCCWFU investigators to discuss the design and analysis plans for potential grants as well as conducting regular grant assistance planning sessions to brainstorm with CCCWFU investigators about potential grants; and 5) Leadership and Training, i.e., participating in CCCWFU committees responsible for scientific and administrative decisions and conducting a monthly seminar series in topics in research methods for CCCWFU members. The BioSR is a highly utilized and cost efficient resource for the CCCWFU. From Nov. 1, 2009 through Oct. 31, 2010, the BioSR provided over 5,000 hours of support for cancer related work. During the same time period, the BioSR assisted over 115 different investigators (71 Scientific members) from all Programs and Centers of Excellence within the CCCWFU. In addition, 20 investigator-initiated institutional protocols were opened, 30 investigator-initiated institutional protocols were monitored, 20 manuscripts (in 2010) were published and over 30 grants submitted with the assistance of the BioSR during this time. For the coming grant period we request at total of 2.45 FTEs of support divided into statistical, administrative and programming support to provide these continued services.