Broad Institute LINCS Center for Transcriptomics
Broad Institute LINCS Center for Transcriptomics
批准号:
8787845
负责人:
TODD R. GOLUB
金额:
$209.28万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-09-10 至 2020-06-30
关键词:
BiologicalBiologyBiomedical ResearchClustered Regularly Interspaced Short Palindromic RepeatsCommunitiesDataDevelopmentDiseaseEducation and OutreachGene ExpressionGenesGeneticGenomeGoalsHealth SciencesInstitutesInstitutionInternetKnock-outLinkMapsMethodsOpen Reading FramesPathway interactionsPharmaceutical PreparationsPhasePhysiologicalPhysiologyReadingResearchResearch InfrastructureResearch PersonnelResourcesScientistSourceTherapeutic EffectUnited States National Institutes of HealthWorkanalytical toolbasecell typecloud basedcostdesignknock-downmRNA Expressionnovel strategiesoverexpressionprogramsprotein functionpublic health relevancerepositoryscale upsmall hairpin RNAsmall moleculetooltranscriptomicsuser-friendly
中文摘要
描述(由申请人提供):该LINCS中心的总体目标是使其产生大规模的药理学和遗传学扰动的一个大面板的细胞类型,开发分析工具,使研究人员能够从数据中进行生物学发现,并使这些数据和工具广泛提供给研究界。我们将使用我们中心开发的L1000转录分析方法来实现这一目标,并通过创建一个基于云的计算基础设施来支持数据API和Web应用程序,这些应用程序旨在使缺乏计算专业知识的生物学家能够进行基于LINCS的发现。
英文摘要
DESCRIPTION (provided by applicant): The overall goal of this LINCS Center is to make it to generate large-scale pharmacological and genetic perturbations of a large panel of cell types, develop analytical tools that enable researchers to make biological discoveries from the data, and to make those data and tools broadly available to the research community. We will accomplish this using the L1000 transcriptional profiling method developed by our Center, and by creating a cloud-based computing infrastructure that supports data APIs and web apps designed make it possible for biologists lacking computational expertise to make LINCS-based discoveries.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Discovering existing medicines that abrogate cellular responses to SARS CoV-2 infection
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批准号:10199270
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项目类别:
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资助金额:$165.28万
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财政年份:2020
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负责人:TODD R. GOLUB
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依托单位:
Making cancer precision medicine real: bottlenecks and opportunities
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批准号:10473781
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项目类别:
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资助金额:$100.38万
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财政年份:2019
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依托单位:
Making cancer precision medicine real: bottlenecks and opportunities
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批准号:10018814
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项目类别:
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资助金额:$102.43万
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财政年份:2019
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负责人:TODD R. GOLUB
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依托单位:
Making cancer precision medicine real: bottlenecks and opportunities
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批准号:9816920
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项目类别:
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资助金额:$102.43万
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财政年份:2019
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负责人:TODD R. GOLUB
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依托单位:
Making cancer precision medicine real: bottlenecks and opportunities
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批准号:10246428
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项目类别:
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资助金额:$84.44万
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财政年份:2019
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负责人:TODD R. GOLUB
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依托单位:
Making cancer precision medicine real: bottlenecks and opportunities
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批准号:10687086
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项目类别:
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资助金额:$100.38万
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财政年份:2019
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负责人:TODD R. GOLUB
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依托单位:
LINCS Data Coordination and Integration Center
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批准号:9096857
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项目类别:
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资助金额:$66.88万
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财政年份:2015
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负责人:TODD R. GOLUB
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依托单位:
LINCS Data Coordination and Integration Center
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批准号:8825090
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项目类别:
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资助金额:$66.88万
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财政年份:2015
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负责人:TODD R. GOLUB
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依托单位:
LINCS Data Coordination and Integration Center
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批准号:9280623
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项目类别:
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资助金额:$66.88万
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财政年份:2015
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负责人:TODD R. GOLUB
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依托单位:
PQB-3: Discovery and validation of the driving mediators of cancer cachexia
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批准号:8792102
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项目类别:
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资助金额:$55.44万
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财政年份:2014
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负责人:TODD R. GOLUB
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依托单位:
Broad Institute LINCS Center for Transcriptomics
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批准号:9098784
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项目类别:
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资助金额:$210.7万
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财政年份:2014
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负责人:TODD R. GOLUB
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依托单位:
PQB-3: Discovery and validation of the driving mediators of cancer cachexia
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批准号:9333287
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项目类别:
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资助金额:$58.56万
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财政年份:2014
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负责人:TODD R. GOLUB
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依托单位:
Broad Institute Center for Cancer Systems Biology
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批准号:8444659
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项目类别:
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资助金额:$200.61万
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财政年份:2013
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负责人:TODD R. GOLUB
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依托单位:
The Dana-Farber Cancer Institute Cancer Target Discovery and Development Center
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批准号:8654308
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项目类别:
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资助金额:$69.37万
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财政年份:2013
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负责人:TODD R. GOLUB
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依托单位:
Broad Institute Center for Cancer Systems Biology
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批准号:8628529
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项目类别:
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资助金额:$6.87万
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财政年份:2013
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负责人:TODD R. GOLUB
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依托单位:
The Dana-Farber Cancer Institute Cancer Target Discovery and Development Center
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批准号:8494195
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项目类别:
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资助金额:$72.59万
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财政年份:2013
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负责人:TODD R. GOLUB
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依托单位:
Broad Institute Center for Cancer Systems Biology
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批准号:8340111
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项目类别:
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资助金额:$203.27万
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财政年份:2011
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负责人:TODD R. GOLUB
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依托单位:
Large scale gene expression analysis of cellular states
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批准号:8254069
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项目类别:
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资助金额:$8.84万
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财政年份:2010
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负责人:TODD R. GOLUB
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依托单位:
Large scale gene expression analysis of cellular states
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批准号:8150481
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项目类别:
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资助金额:$232.26万
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财政年份:2010
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负责人:TODD R. GOLUB
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依托单位:
Large scale gene expression analysis of cellular states
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批准号:8539125
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项目类别:
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资助金额:$12.0万
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财政年份:2010
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负责人:TODD R. GOLUB
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依托单位:
国内基金
海外基金
Journal of Integrative Plant Biology
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批准号:31024801
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项目类别:专项基金项目
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资助金额:24.0万元
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批准年份:2010
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负责人:贺萍
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依托单位: