Mechanisms of Disease & Translational Science

描述(由申请者提供)：德克萨斯大学西南研究生院的疾病机制和转化科学博士培训课程(MOD)将培养一批精英博士生，使他们成为下一代转化科学家的领导者。研究生院的基础科学(DBS)和临床科学(DC)分部将合作，为学生提供新的机会，在基础科学和临床科学之间研究人类疾病。国防部的主要目标是培养一批新的博士级别的科学家，能够针对他们的研究计划来解决未来未得到满足的治疗和诊断需求。理论基础：翻译研究是在从长凳到床边和床后的连续体中进行的，从事翻译早期阶段(T1)的博士生必须具有现代分子方法以及人类生理学和病理学的基础。他们还必须学会驾驭基于团队的临床研究环境，并与临床医生沟通。为了实现这些目标，我们设计了MOD作为一个补充轨道，覆盖在现有的十个星展博士研究生项目上。通过这种方式，我们协同和补充现有的计划，并专注于创建一种新的培训模式。国防部独特的培训课程旨在提高翻译能力，现有课程中没有提供该课程。除了开发MOD教学课程外，MOD还利用DC丰富的临床和翻译教育资源，提供患者护理和临床研究方面的结构化经验，并介绍衔接基础课程和教学课程的机遇和挑战。实习生：我们寻求T32资助，在第一年和第二年资助6名博士前学生，在接下来的几年支持7名博士后学生。在竞争的基础上完成第一年研究生培训的星展银行学生将获得国防部的任命。持续时间：拟议的培训期限为16个月，尽管MOD Track学生继续参与该计划。我们只要求为每个学生提供12个月的T32支持，以便能够每年任命固定数量的新学生。预期结果：MOD Track提供了独特的机会和严格的培训来填充早期T1翻译研究连续体，T32资助将使我们能够进一步改进和扩大我们培养博士翻译科学家的努力。国防部的学生将配备“智力”和“实用”工具包，带头将发现双向转化，以改善人类健康。国防部计划是创新的、可持续的和具有成本效益的。它独特地利用现有的机构优势创建了一个新颖的翻译科学培训计划，补充了校园其他计划的研究和教育使命。它非常成功，我们预计，有了新的T32资金，它将对翻译生物医学劳动力的生成产生重大影响。

DESCRIPTION (provided by applicant): The Mechanisms of Disease and Translational Science PhD Training Track (MoD) at the UT Southwestern Graduate School will train an elite group of PhD students to become the leaders of the next generation of translational scientists. The Graduate School's Divisions of Basic Science (DBS) and Clinical Science (DCS) will collaborate to provide students with new opportunities to study human diseases at the interface between basic and clinical sciences. MoD's primary goal is to create a new breed of PhD-level scientists capable of targeting their research programs to address unmet therapeutic and diagnostic needs of the future. Rationale: Translational research occurs in a bench to bedside & back continuum, and PhD students who engage in the early phase of translation (T1) must have a foundation in modern molecular approaches as well as in human physiology and pathology. They will also have to learn to navigate the team based clinical research environment and to communicate with clinicians. To accomplish these goals, we designed MoD as a supplemental track that is overlaid on the ten existing DBS PhD graduate programs. In this way, we synergize and complement existing programs, and are focused on creating a new training paradigm. MoD's unique training curriculum is designed to increase translational competencies and is not available in existing programs. In addition to developing MoD didactic courses, MoD has leveraged the rich clinical and translational education resources of DCS to offer structured experiences in patient care and clinical research and exposures to the opportunities and challenges of bridging basic and didactic courses. Trainees: We seek T32 funding to support 6 predoctoral PhD students in years 1 and 2, and 7 in subsequent years. MoD appointments are made to DBS students who are completing the first year of graduate training on a competitive basis. Duration: The duration of proposed training is for 16 months, although MoD track students continue to be associated with the program. We are only asking 12 months of T32 support for each student, in order to be able to appoint a constant number of new students each year. Anticipated Outcomes: The MoD Track provides unique opportunities and rigorous training to populate the early T1 translational research continuum, and T32 funding will allow us to further improve and expand our efforts to train PhD translational scientists. MoD students will be equipped with the "intellectual" and "practical" toolkits to spearhead the bidirectional translatio of discoveries to improve human health. The MoD plan is innovative, sustainable and cost-effective. It uniquely exploits existing institutional strengths to create a novel translational science training program that complements the research and educational mission of other programs on campus. It has been very successful and we anticipate that with new T32 funding it will have significant impact in the generation of a translational biomedical workforce.