Disparities in Exposure and Health Effects of Multiple Environmental Stressors Across the Life Course

描述（由申请人提供）：拟建的环境健康差异研究卓越中心（EHD），题为“生命历程中多种环境压力源的暴露和健康影响差异”，是一个高度整合和协作的项目。该中心包括三个相互依赖和相互通知的研究项目，一个直接为研究任务做出贡献并传播所有项目成果的社区参与核心，以及一个试点项目计划，该计划加强了我们在马萨诸塞州两个选定社区的当前研究工作，并将其扩展到美国的其他人群。中心的核心人员都表现出成功协调和完成复杂跨学科项目的能力，包括一些涉及多个中心成员的项目。我们在这些成功经验的基础上设计了行政核心，同时添加了新的组件，以最大限度地提高集成和生产力。行政核心将通过协调研究工作和跟踪各项目和各大学的进展情况来支持中心的所有活动；提供财政和资源管理；对数据收集和管理工作进行监督；与咨询委员会、资助机构和社区合作伙伴保持沟通；建立和维护职业发展计划；并将中心活动与哈佛大学陈曾熙公共卫生学院（HSPH）、哈佛医学院（HMS）、波士顿大学公共卫生学院（BUSPH）、波士顿大学医学院（BUSM）和其他EHD中心的相关工作联系起来。具体目标是：(1)提供必要的整体行政基础设施，以协调研究项目之间的活动；(2)监控本中心及其下属机构的生产力和资源；(3)组建中心内部指导委员会和外部咨询委员会；(4)为中心的职业发展调查员（cdi）和其他早期调查员提供指导和职业发展机会；(5)将中心调查人员和活动与HSPH/HMS和BUSPH/BUSM的各种相关工作联系起来；(6)提供向科学界感兴趣的利益相关者、目标社区内的人群和一般人群传播研究成果的平台。

DESCRIPTION (as provided by applicant): The proposed Center of Excellence on Environmental Health Disparities Research (EHD), titled Disparities in Exposure and Health Effects of Multiple Environmental Stressors across the Life Course is structured to be a highly integrated and collaborative program. The Center includes three Research Projects that depend on and inform one another, a Community Engagement Core that contributes directly to the research mission and disseminates findings from all projects, and a Pilot Project Program that enhances our current research efforts in two selected communities in Massachusetts and extends them to other populations in the United States. The key personnel within the Center have all demonstrated the ability to successfully coordinate and complete complex interdisciplinary projects, including a number of projects involving multiple Center members. We have designed the Administrative Core to build on these successful experiences while adding novel components to maximize integration and productivity. The Administrative Core will support all activities of the Center by coordinating research efforts and tracking progress across the projects and universities; providing fiscal and resource management; providing oversight of data collection and management efforts; maintaining communication with advisory boards, funding agencies, and community partners; establishing and maintaining a career development program; and connecting Center activities with related efforts at the Harvard T.H. Chan School of Public Health (HSPH), Harvard Medical School (HMS), Boston University School of Public Health (BUSPH), Boston University School of Medicine (BUSM), and other EHD Centers. The Specific Aims are: (1) provide the overall administrative infrastructure necessary to coordinate activities among research projects; (2) monitor the productivity and resources of the Center and its subcomponents; (3) assemble an Internal Steering Committee and External Advisory Board for the Center; (4) provide mentoring and career development opportunities for the Center's Career Development Investigators (CDIs) and other early-stage investigators; (5) connect Center investigators and activities with various related efforts at HSPH/HMS and BUSPH/BUSM; and (6) provide platforms for disseminating research findings to interested stakeholders in the scientific community, populations within the target communities, and the general population.