Early life exposure to the natural, built, and social environments and incident hypertension

生命早期接触自然、建筑和社会环境和高血压事件

• 批准号: 9905520
• 负责人: Francine Laden
• 金额: $ 69.48万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-02 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9905520
• 关键词: 15 year old; Address; Adolescence; Adult; Age; Age-Years; Air Pollution; American; American Heart Association; Attenuated; Behavior; Behavioral; Biological; Blood Pressure; Cardiology; Cardiovascular Diseases; Characteristics; Chemicals; Child; Child Abuse; Childhood; Complex; Data; Detection; Development; Diet; Disease; Enrollment; Environment; Environmental Exposure; Environmental Risk Factor; Evaluation; Exposure to; Family; Female; Future; Gender; Goals; Guidelines; Health; Humidity; Hypertension; Incidence; Individual; Joints; Life Style; Light; Mediating; Mental Health; Modification; Mothers; Neighborhoods; Noise; Nurses' Health Study; Obesity; Ozone; Parent-Child Relations; Participant; Particulate Matter; Pathway interactions; Physical activity; Policies; Pollution; Population; Population Density; Positioning Attribute; Prevalence; Prevention; Prevention Guidelines; Process; Prospective cohort study; Race; Reporting; Resources; Risk; Risk Assessment; Risk Factors; Role; Social Environment; Socioeconomic Status; Symptoms; Temperature; Time; Ultraviolet Rays; United States; Update; Violence; Vitamin D Deficiency; Woman; base; built environment; coarse particles; college; demographics; early life exposure; environmental agent; experience; male; men; modifiable risk; offspring; prospective; public health priorities; public health relevance; sex; social factors; stressor; walkability; young adult

PROJECT SUMMARY Over a third of adults in the United States were previously estimated to have hypertension, defined since 2003 as a blood pressure of 140/90mm Hg. This prevalence is expected to increase throughout the population, but especially among younger adults, given the recent American College of Cardiology (ACC) and American Heart Association (AHA) update to the definition of hypertension to 130/80mm Hg. The ACC/AHA anticipate that the new definition will result in a tripling of prevalence of hypertension in men under 45 and a doubling among women under 45. Therefore, risk factors among young adults are critical to assess. Diet, obesity, and physical activity are known risk factors, and a growing body of evidence suggests that exposures to air pollution are also associated with risk. However, to date, no study has been able to examine the role of multiple environmental exposures throughout childhood on risk of subsequent hypertension in adulthood, nor how environmental exposures interact with features of the built and social environments to influence risk. The objectives of our study are (1) to determine how features of the total environment experienced during childhood are associated with incident hypertension during adulthood; (2) to examine effect modification of the associations of features of the total environment experienced during childhood with incident hypertension; and (3) to explore how known risk factors of hypertension mediate the associations of the total environment on risk of incident hypertension. We will use the unique resources of the Growing Up Today Study (GUTS) to meet these objectives. GUTS is a prospective cohort study of children whose mothers are participants in the ongoing Nurses’ Health Study II who were first enrolled when they were 9-15 years of age and are currently 22-38 years of age. We will append information on multiple chemical stressors (particulate matter (PM2.5, PM10, PM2.5-10), NO2, ozone), physical stressors (temperature, humidity, noise, light at night, ultraviolet radiation), features of the built and natural environments (proximity to roadways, greenness, blue space, walkability, population density) to the residential addresses of each participant throughout childhood. We will combine the environmental factors with time-varying data collected on social factors (demographics, family socioeconomic status, family make-up and interactions, relationships, team/club participation, experiences with violence/abuse), mental health scales/symptoms, activities/behaviors (e.g. diet and physical activity), and inherent characteristics (e.g. age, sex/gender, race, age at pubertal development). We expect our findings to provide valuable information on the role of childhood exposures on subsequent disease in adulthood, as well as how exposures to multiple factors interact or mediate these exposures, providing valuable information for individual and population level prevention, future risk assessments, and policy decisions.

项目总结 超过三分之一的美国成年人之前被估计患有高血压，自2003年以来一直被定义为高血压 血压为140/90毫米汞柱。这种流行率预计将在整个人口中增加，但 尤其是在年轻人中，考虑到最近的美国心脏病学会(ACC)和美国心脏 美国医学会(AHA)将高血压的定义更新为130/80毫米汞柱。行政协调委员会/AHA预计 新定义将导致45岁以下男性高血压患病率增加两倍，女性增加一倍 45岁以下。因此，年轻人中的风险因素是评估的关键。饮食、肥胖和体力活动 是已知的危险因素，越来越多的证据表明，暴露在空气污染中也是 与风险相关。然而，到目前为止，还没有一项研究能够检查多种环境因素的作用 儿童时期对成年后高血压风险的暴露，也不知道环境如何 暴露与建筑和社会环境的特征相互作用，从而影响风险。我们研究的目标是 是(1)确定儿童时期所经历的总体环境的特征如何与 成年后发生高血压事件；(2)检查特征的关联的效果修改 儿童时期经历的突发高血压的总体环境；以及(3)探索如何知道风险 高血压因素在总环境对高血压发病风险的影响中起中介作用。我们 将利用今日成长研究(GUTS)的独特资源来实现这些目标。胆量是一种 母亲是正在进行的世卫组织护士健康研究II的儿童的前瞻性队列研究 他们第一次注册时是9-15岁，目前是22-38岁。我们将追加 关于多种化学应激源的信息(颗粒物(PM2.5、PM10、PM2.5-10)、NO2、臭氧)、物理 应激源(温度、湿度、噪音、夜间光线、紫外线辐射)、建筑物和天然建筑物的特征 环境(接近道路、绿色、蓝色空间、可步行、人口密度)与住宅 每个参与者在整个童年时期的地址。我们将环境因素与时变因素结合起来 收集的关于社会因素的数据(人口统计、家庭社会经济地位、家庭构成和互动、 人际关系、团队/俱乐部参与、暴力/虐待经历)、心理健康量表/症状、 活动/行为(如饮食和体力活动)和固有特征(如年龄、性别/性别、种族、年龄 在青春期发育时)。我们希望我们的发现能为儿童的角色提供有价值的信息 成年期对后续疾病的暴露，以及暴露于多种因素的相互作用或调节 这些暴露，为个人和人群层面的预防、未来风险提供了有价值的信息 评估和政策决定。