Early life exposure to the natural, built, and social environments and incident hypertension

生命早期接触自然、建筑和社会环境和高血压事件

• 批准号: 10375447
• 负责人: Francine Laden
• 金额: $ 63.7万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-02 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10375447
• 关键词: 15 year old; Address; Adolescence; Adult; Age; Age-Years; Air Pollution; American; American Heart Association; Attenuated; Behavior; Behavioral; Biological; Blood Pressure; Cardiology; Cardiovascular Diseases; Characteristics; Chemicals; Child; Child Abuse; Childhood; Complex; Data; Detection; Development; Diet; Disease; Enrollment; Environment; Environmental Exposure; Environmental Risk Factor; Evaluation; Exposure to; Family; Female; Future; Gender; Goals; Guidelines; Health; Health behavior; Humidity; Hypertension; Incidence; Individual; Joints; Life Style; Light; Mediating; Mental Health; Modification; Mothers; Neighborhoods; Nitrogen Dioxide; Noise; Nurses' Health Study; Obesity; Ozone; Parent-Child Relations; Participant; Particulate Matter; Pathway interactions; Physical activity; Policies; Pollution; Population; Population Density; Positioning Attribute; Prevalence; Prevention; Prevention Guidelines; Process; Prospective cohort study; Race; Reporting; Resources; Risk; Risk Assessment; Risk Factors; Role; Social Environment; Socioeconomic Status; Symptoms; Temperature; Time; Ultraviolet Rays; United States; Update; Violence; Vitamin D Deficiency; Woman; base; built environment; coarse particles; college; demographics; early life exposure; environmental agent; experience; fine particles; male; men; modifiable risk; offspring; prospective; public health priorities; public health relevance; sex; social factors; stressor; walkability; young adult

PROJECT SUMMARY Over a third of adults in the United States were previously estimated to have hypertension, defined since 2003 as a blood pressure of 140/90mm Hg. This prevalence is expected to increase throughout the population, but especially among younger adults, given the recent American College of Cardiology (ACC) and American Heart Association (AHA) update to the definition of hypertension to 130/80mm Hg. The ACC/AHA anticipate that the new definition will result in a tripling of prevalence of hypertension in men under 45 and a doubling among women under 45. Therefore, risk factors among young adults are critical to assess. Diet, obesity, and physical activity are known risk factors, and a growing body of evidence suggests that exposures to air pollution are also associated with risk. However, to date, no study has been able to examine the role of multiple environmental exposures throughout childhood on risk of subsequent hypertension in adulthood, nor how environmental exposures interact with features of the built and social environments to influence risk. The objectives of our study are (1) to determine how features of the total environment experienced during childhood are associated with incident hypertension during adulthood; (2) to examine effect modification of the associations of features of the total environment experienced during childhood with incident hypertension; and (3) to explore how known risk factors of hypertension mediate the associations of the total environment on risk of incident hypertension. We will use the unique resources of the Growing Up Today Study (GUTS) to meet these objectives. GUTS is a prospective cohort study of children whose mothers are participants in the ongoing Nurses’ Health Study II who were first enrolled when they were 9-15 years of age and are currently 22-38 years of age. We will append information on multiple chemical stressors (particulate matter (PM2.5, PM10, PM2.5-10), NO2, ozone), physical stressors (temperature, humidity, noise, light at night, ultraviolet radiation), features of the built and natural environments (proximity to roadways, greenness, blue space, walkability, population density) to the residential addresses of each participant throughout childhood. We will combine the environmental factors with time-varying data collected on social factors (demographics, family socioeconomic status, family make-up and interactions, relationships, team/club participation, experiences with violence/abuse), mental health scales/symptoms, activities/behaviors (e.g. diet and physical activity), and inherent characteristics (e.g. age, sex/gender, race, age at pubertal development). We expect our findings to provide valuable information on the role of childhood exposures on subsequent disease in adulthood, as well as how exposures to multiple factors interact or mediate these exposures, providing valuable information for individual and population level prevention, future risk assessments, and policy decisions.

项目摘要 据估计，自2003年以来，美国超过三分之一的成年人患有高血压 血压为140/90毫米汞柱。这种流行率预计将在整个人口中增加，但 特别是在年轻人中，考虑到最近的美国心脏病学会（ACC）和美国心脏病学会（ACC）， 美国心脏协会（AHA）将高血压的定义更新为130/80 mm Hg。ACC/AHA预计， 新的定义将导致45岁以下男性高血压患病率增加两倍，女性增加一倍 45岁以下因此，评估年轻人的风险因素至关重要。饮食、肥胖和体力活动 是已知的风险因素，越来越多的证据表明，暴露于空气污染也是 与风险相关。然而，到目前为止，还没有研究能够检查多种环境因素的作用。 在整个儿童期暴露于高血压的风险，在成年期，也没有如何环境 暴露与建筑和社会环境的特征相互作用，从而影响风险。我们研究的目的 （1）确定儿童时期所经历的总环境的特征与 成年期高血压事件;（2）检查影响修改的协会的特点， 总的环境经历在儿童时期与事件高血压;和（3）探讨如何已知的风险 高血压因素介导了总环境对高血压发病风险的影响。我们 我们将利用今天成长研究（GUTS）的独特资源来实现这些目标。GUTS是一个 一项前瞻性队列研究，研究对象是母亲参与正在进行的护士健康研究II的儿童， 首次入组时为9-15岁，目前为22-38岁。我们将附加 关于多种化学压力源的信息（颗粒物（PM2.5、PM10、PM2.5-10）、NO2、臭氧）、物理 压力源（温度，湿度，噪音，夜间光线，紫外线辐射），建筑和自然的特征 环境（接近道路，绿色，蓝色空间，步行能力，人口密度）的住宅 每个参与者在整个童年的地址。我们将联合收割机的环境因素与时变 收集的关于社会因素的数据（人口统计、家庭社会经济地位、家庭组成和互动， 关系，团队/俱乐部参与，暴力/虐待经历），心理健康量表/症状， 活动/行为（例如饮食和体育活动）和固有特征（例如年龄、性别/性别、种族、年龄 青春期发育）。我们希望我们的研究结果能为儿童的作用提供有价值的信息 暴露于成年后的疾病，以及暴露于多种因素如何相互作用或介导 这些暴露，为个人和群体预防提供了有价值的信息， 评估和政策决定。