Early life exposure to the natural, built, and social environments and incident hypertension

生命早期接触自然、建筑和社会环境和高血压事件

• 批准号: 9764825
• 负责人: Francine Laden
• 金额: $ 66.67万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-02 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9764825
• 关键词: 15 year old; Address; Adolescence; Adult; Age; Age-Years; Air Pollution; American; American Heart Association; Attenuated; Behavior; Behavioral; Biological; Blood Pressure; Cardiology; Cardiovascular Diseases; Characteristics; Chemicals; Child; Child Abuse; Childhood; Complex; Data; Detection; Development; Diet; Disease; Enrollment; Environment; Environmental Exposure; Environmental Risk Factor; Evaluation; Exposure to; Family; Female; Future; Gender; Goals; Guidelines; Health; Humidity; Hypertension; Incidence; Individual; Joints; Life Style; Light; Mediating; Mental Health; Modification; Mothers; Neighborhoods; Noise; Nurses' Health Study; Obesity; Ozone; Parent-Child Relations; Participant; Particulate Matter; Pathway interactions; Physical activity; Policies; Pollution; Population; Population Density; Positioning Attribute; Prevalence; Prevention; Prevention Guidelines; Process; Prospective cohort study; Race; Reporting; Resources; Risk; Risk Assessment; Risk Factors; Role; Social Environment; Socioeconomic Status; Symptoms; Temperature; Time; Ultraviolet Rays; United States; Update; Violence; Vitamin D Deficiency; Woman; base; built environment; coarse particles; college; demographics; early life exposure; environmental agent; experience; male; men; modifiable risk; offspring; prospective; public health priorities; public health relevance; sex; social; stressor; walkability; young adult

PROJECT SUMMARY Over a third of adults in the United States were previously estimated to have hypertension, defined since 2003 as a blood pressure of 140/90mm Hg. This prevalence is expected to increase throughout the population, but especially among younger adults, given the recent American College of Cardiology (ACC) and American Heart Association (AHA) update to the definition of hypertension to 130/80mm Hg. The ACC/AHA anticipate that the new definition will result in a tripling of prevalence of hypertension in men under 45 and a doubling among women under 45. Therefore, risk factors among young adults are critical to assess. Diet, obesity, and physical activity are known risk factors, and a growing body of evidence suggests that exposures to air pollution are also associated with risk. However, to date, no study has been able to examine the role of multiple environmental exposures throughout childhood on risk of subsequent hypertension in adulthood, nor how environmental exposures interact with features of the built and social environments to influence risk. The objectives of our study are (1) to determine how features of the total environment experienced during childhood are associated with incident hypertension during adulthood; (2) to examine effect modification of the associations of features of the total environment experienced during childhood with incident hypertension; and (3) to explore how known risk factors of hypertension mediate the associations of the total environment on risk of incident hypertension. We will use the unique resources of the Growing Up Today Study (GUTS) to meet these objectives. GUTS is a prospective cohort study of children whose mothers are participants in the ongoing Nurses’ Health Study II who were first enrolled when they were 9-15 years of age and are currently 22-38 years of age. We will append information on multiple chemical stressors (particulate matter (PM2.5, PM10, PM2.5-10), NO2, ozone), physical stressors (temperature, humidity, noise, light at night, ultraviolet radiation), features of the built and natural environments (proximity to roadways, greenness, blue space, walkability, population density) to the residential addresses of each participant throughout childhood. We will combine the environmental factors with time-varying data collected on social factors (demographics, family socioeconomic status, family make-up and interactions, relationships, team/club participation, experiences with violence/abuse), mental health scales/symptoms, activities/behaviors (e.g. diet and physical activity), and inherent characteristics (e.g. age, sex/gender, race, age at pubertal development). We expect our findings to provide valuable information on the role of childhood exposures on subsequent disease in adulthood, as well as how exposures to multiple factors interact or mediate these exposures, providing valuable information for individual and population level prevention, future risk assessments, and policy decisions.

项目概要 自 2003 年起定义，美国超过三分之一的成年人此前被估计患有高血压 血压为 140/90mm Hg。预计这种患病率会在整个人群中增加，但是 鉴于最近美国心脏病学会 (ACC) 和美国心脏协会 (American Heart) 协会 (AHA) 将高血压的定义更新为 130/80mm Hg。 ACC/AHA 预计 新定义将导致 45 岁以下男性高血压患病率增加两倍，女性高血压患病率增加一倍 45岁以下。因此，评估年轻人的危险因素至关重要。饮食、肥胖和体力活动 是已知的风险因素，越来越多的证据表明，接触空气污染也会影响健康。 与风险相关。然而，迄今为止，还没有研究能够检验多种环境因素的作用。 整个童年时期的暴露对成年后患高血压的风险的影响，以及环境对成年后患高血压的风险的影响 暴露与建筑和社会环境的特征相互作用，从而影响风险。我们的研究目标 (1) 确定童年时期经历的总体环境特征如何与 成年期间发生高血压； (2)检验特征关联的修改效果 童年时期发生高血压所经历的总体环境； (3) 探讨如何已知风险 高血压因素介导总环境与高血压发生风险的关联。我们 将利用今日成长研究 (GUTS) 的独特资源来实现这些目标。 GUTS 是一个 对母亲参与正在进行的护士健康研究 II 的儿童进行的前瞻性队列研究 首次入学年龄为 9-15 岁，目前年龄为 22-38 岁。我们将追加 有关多种化学压力源（颗粒物（PM2.5、PM10、PM2.5-10）、NO2、臭氧）、物理压力源的信息 压力源（温度、湿度、噪音、夜间光线、紫外线辐射）、建筑特征和自然特征 住宅区的环境（靠近道路、绿化、蓝色空间、步行性、人口密度） 每个参与者整个童年时期的地址。我们将环境因素与时变相结合 收集的社会因素数据（人口统计、家庭社会经济地位、家庭构成和互动、 关系、团队/俱乐部参与、暴力/虐待经历）、心理健康量表/症状、 活动/行为（例如饮食和体力活动）和固有特征（例如年龄、性别、种族、年龄） 青春期发育时）。我们希望我们的研究结果能够提供有关童年角色的有价值的信息 成年后后续疾病的暴露，以及多种因素的暴露如何相互作用或介导 这些暴露，为个人和人群层面的预防、未来风险提供了有价值的信息 评估和政策决定。