Research Training for Medical Geneticists at Mount Sinai School of Medicine

描述(申请人提供)：本申请寻求在06-10年度继续提供名为“医学遗传学家研究培训计划”的博士后培训资助。该计划的总体目标是为医学遗传学家提供有指导的研究经验，以进行富有成效的独立基础/翻译研究，并培养有效竞争联邦资金并成为医学遗传学和基因组学学术领袖所需的技能和经验。该计划的重点是遗传学和基因组学的基础和翻译研究，包括应用基因组测序和分析、生物信息学和系统生物学分析方面的最新和持续的进展，以了解单基因和复杂性状的遗传学/基因组学，并将这些发现转化为改进的诊断、预防和新的有效治疗方法。被选中参加这一项目的医学博士实习生将完成医学遗传学的住院医师资格。我们的医学遗传学住院医师计划为优秀的候选人提供了一条渠道，这些候选人表现出了对基础/翻译研究事业的承诺。来自其他住院医师培训项目的高资质医学遗传学家申请者和代表性不足的少数族裔候选人也将被招募。受训者将在我们的一名研究指导教师的密切监督下接受为期2至3年的支持，每个受训者都将有一个适当的咨询委员会。该项目之前的学员已经成功地获得了学术/行业职位，并申请/获得了联邦资助。这一培训计划以西奈山的大量资源为基础，其中包括：1)一批受资助的多学科研究项目研究导师，以及担任临床实验室P受体和研究核心主任的教职员工；2)我们获得认可的ABMG所有专业的医学遗传学培训课程；3)基础翻译研究方法和负责任的研究行为方面的授课选修课程；4)共享研究设施(SRF)和以疾病为导向和核心技术的研究机构的基础设施，包括我们新的基因组学和多尺度生物学研究所。所有受训人员将参加每月一次的培训资助会议、我们每周的工作进展会议、每周的遗传学/基因组学系列研讨会，以及我们与外部咨询委员会的年度研究日。这一培训计划将满足对独立医学遗传学家的迫切需求，他们能够将遗传学/基因组学的进步转化为人类疾病的改进诊断和治疗。

DESCRIPTION (provided by applicant): This application seeks to continue for years 06-10 the postdoctoral training grant entitled, "Research Training Program for Medical Geneticists." The program's overall goal is to provide a mentored research experience for M.D. medical geneticists to perform productive independent basic/ translational research and to develop the skills and experience required to effectively compete for federal funding and become academic leaders in medical genetics and genomics. The program's emphasis is on basic and translational research in genetics and genomics, including the application of recent and continuing advances in genome sequencing and analysis, bioinformatics, and systems biology analyses, towards the understanding of the genetics/genomics of monogenic and complex traits, and to translate these findings into improved diagnosis, prevention, and new effective therapies. MD trainees chosen for this program will have completed a residency in Medical Genetics. Our Medical Genetics residency programs provides a pipeline of outstanding candidates who have demonstrated a commitment to a basic/ translational research career. Highly qualified medical geneticist applicants from other residency training programs and underrepresented minority candidates will also be recruited. Trainees will be supported for a period of 2 to 3 years under close supervision of one of our Research Mentor faculty, and each trainee will have an appropriate Advisory Committee. Previous trainees from this program have successfully obtained academic/ industry positions and have applied for/ received federal funding. This training program builds upon considerable resources at Mount Sinai including: 1) an exceptional group of funded Research Mentors in multidisciplinary research programs, as well as faculty who serve as Clinical Laboratory Preceptors and Research Core Directors; 2) our accredited Medical Genetics training programs in all the ABMG specialties; 3) didactic elective courses in basic translational research methodology, and responsible conduct of research, 4) an infrastructure of Shared Research Facilities (SRFs) and disease-oriented and core-technology-based research institutes, including our new Institute for Genomics and Multiscale Biology. All trainees will participate in a monthly Training Grant Conference, our weekly work-in progress conference, weekly Genetics/Genomics seminar series, and our annual Research Day with our External Advisory Committee. This training program will meet a critical need for independent medical geneticists who can translate advances in genetics/ genomics into improved diagnosis and treatment of human disease.