Integrative Pathways to Health and Illness

摘要--总体 这一修改后的申请是对U19为美国中年提供资金的机会的回应 (MIDUS)研究。MIDUS的使命是研究广义上的健康，将其作为一种综合的生物心理社会 这一过程贯穿了成年人几十年的生活。这项基线研究始于1995年，共有7000多人参与 成年人，包括双胞胎，年龄在25岁到74岁之间。这个样本已经被跟踪了20年，在此过程中，MIDUS 增加了特定城市的非裔美国人样本，最近，又招募了一名新的国家 示例，称为MIDUS刷新程序。采用多项目设计、综合调查、生物医学、 并收集了MIDUS受访者的神经科学数据。此外，目前P01的资金用于 MIDUS促进了第三波调查数据和第二波认知数据的完成。我们在寻找 此应用程序中用于为Daily Diary项目、Biomarker项目和 神经科学项目。我们还要求提供资金，以启动一个新的基因表达项目，重点是 机体免疫-炎症反应中心基因的表达以及早期滞留 警告项目，旨在恢复之前一波数据收集中的部分辍学。这五个人 项目由管理核心、生物核心和统计核心提供支持。跨所有项目和 关于核心问题，针对上一次审查中提出的关切，汇编了详细的答复。在……里面 此外，总体计划记录了围绕MIDUS研究发展起来的巨大势头，通过 关于数据使用和科学生产力的最新情况，包括产生大量新出版物(88份) 就在十个月前这份申请第一次提交之后。 MIDUS在NIA支持的纵向研究中填补了一个独特的利基市场，因为其广泛的年龄范围和 在心理社会、生物标记物和神经科学评估方面的不同寻常的深度，这使得我们能够专注于 社会人口学和心理社会因素的神经生物学机制和途径 影响正在展开的健康和疾病概况。一个独特的优势是对心理社会的主题关注 力量，这是用来解释在许多成年人面临各种不同的 逆境。MIDUS还包括一对全国性的双胞胎样本，从而提供了独特的进步机会 了解遗传和环境因素在理解健康或不健康衰老方面的相互作用。 重要的是，MIDUS引起了科学界的注意：它是最频繁的 在国家老龄数据计算机化档案馆(NACDA)下载的研究。近700种出版物 已经产生，许多人在建立社会人口、心理社会、 以及神经生物学因素，以解释导致晚年发病率和死亡率的不同途径。

ABSTRACT - Overall This revised application is in response to the U19 funding opportunity for the Midlife in the United States (MIDUS) study. The mission of MIDUS is to study health, broadly defined, as an integrated biopsychosocial process that unfolds across the decades of adult life. The baseline study was begun in 1995 with over 7,000 adults, including twins, aged 25 to 74. This sample has been followed for 20 years, and along the way, MIDUS was augmented with city-specific sample of African Americans, and more recently, a newly recruited national sample, known as the MIDUS Refresher. Using a multi-project design, comprehensive survey, biomedical, and neuroscience data have been collected on MIDUS respondents. In addition, current P01 funding of MIDUS has facilitated the completion of a 3rd wave of survey data and 2nd wave of cognitive data. We seek funds in this application to collect longitudinal data for the Daily Diary Project, the Biomarker Project, and the Neuroscience Project. We also request funds to initiate a new Gene Expression Project focused on the expression of genes central to the body's immune-inflammatory response as well as a Retention-Early Warning Project, designed to reinstate a portion of drop-outs from prior waves of data collection. These five projects are supported by an Administrative Core, a Bio Core, and a Statistics Core. Across all projects and cores, detailed responses have been assembled in response to concerns raised in the prior review. In addition, the Overall Plan documents the enormous momentum that has grown up around the MIDUS study via updates on data usage and scientific productivity, including the high volume of new publications (88) generated just since this application was first submitted ten months ago. MIDUS fills a unique niche among NIA-supported longitudinal studies, given its wide age expanse and its unusual depth in psychosocial, biomarker, and neuroscience assessments, which permit a focus on the neurobiological mechanisms and pathways through which sociodemographic and psychosocial factors influence unfolding profiles of health and illness. A unique strength is the thematic focus on psychosocial strengths, which are being used to explicate profiles of resilience in many adults confronted with varieties of adversity. MIDUS also includes a national twin sample, thus offering unique opportunities to advance knowledge of the interplay of genetic and environmental factors in understanding healthy or unhealthy aging. Importantly, MIDUS has captured the attention of the scientific community: it is the most frequently downloaded study at the National Archive of Computerized Data on Aging (NACDA). Nearly 700 publications have been generated, many breaking new ground in forging linkages among sociodemographic, psychosocial, and neurobiological factors to account for differing pathways to later life morbidity and mortality.