Caribbean, Central and South America Network for HIV Epidemiology (CCASAnet)

 描述(由申请人提供)：加勒比、中美洲和南美洲艾滋病毒流行病学网络(CCASAnet)是国际艾滋病流行病学数据库评估(LeDEA)计划内建立的一个富有成效的网络。CCASAnet是在2006年第一个leDEA资助周期中创建的，汇集了海地太子港、墨西哥墨西哥城、洪都拉斯特古西加尔巴、秘鲁利马、阿根廷布宜诺斯艾利斯、智利圣地亚哥、巴西里约热内卢、贝洛奥里藏特和圣保罗的艾滋病毒临床护理和研究机构的临床、统计流行病学和信息学资源，以及美国纳什维尔的协调中心。CCASAnet协作的成员共同应对该区域和世界各地艾滋病毒研究网络出现的科学机会。位于范德比尔特大学(VDCC)的CCASAnet数据协调中心管理CCASAnet联合体，并致力于协调和分析参与站点产生的复杂数据库。VDCC还提供指导和教育，以增强CCASAnet网站的临床研究和数据管理能力，提拔初级研究人员，并促进该地区科学领导地位的持续增长。在接下来的五年里，亚太艾滋病防治中心将评估该地区与艾滋病毒感染和抗逆转录病毒治疗有关的临床结果和并发症，并确定艾滋病毒以外的其他感染，特别是结核病、肝炎、人乳头瘤病毒和登革热的影响。CCASAnet的研究将调查癌症和心脏病等非传染性疾病、艾滋病毒流行的区域趋势及其对脆弱人群的影响，以及拉丁美洲其他对公共卫生具有重要意义的问题。此外，研究将解决与儿童、青少年和青少年艾滋病毒携带者独特相关的因素。我们将继续开发和应用创新的生物统计和信息学方法，加强与IeDEA其他地区的富有成效的合作，并在现场评估和数据协调倡议方面发挥领导作用。通过这些活动，CCASAnet 3.0将有助于推动艾滋病毒流行病学科学和支撑国际研究合作的信息科学。

 DESCRIPTION (provided by applicant): The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) is an established and productive network within the International epidemiologic Databases to Evaluate AIDS (leDEA) program. CCASAnet was created in 2006 during the first leDEA funding cycle and has brought together clinical, statistical epidemiologic, and informatics resources from HIV clinical care and research sites in Port-au-Prince, Haiti; Mexico City, Mexico; Tegucigalpa, Honduras; Lima, Peru; Buenos Aires, Argentina; Santiago, Chile; and Rio de Janeiro, Belo Horizonte, and Sao Paulo, Brazil, along with a coordinating center in Nashville, USA. Together, the members of the CCASAnet collaboration respond to scientific opportunities arising in the region and across HIV research networks worldwide. The CCASAnet Data Coordinating Center at Vanderbilt University (VDCC) manages the CCASAnet consortium and works to harmonize and analyze the complex databases generated by participating sites. The VDCC also provides mentoring and education to enhance clinical research and data management capabilities at CCASAnet sites, promote junior researchers, and catalyze ongoing growth of scientific leadership in the region. Over the next five years, CCASAnet will evaluate clinical outcomes and complications related to HIV infection and antiretroviral therapy in the region, and determine the impact of infections other than HIV, particularly tuberculosis, hepatitis, human papillomavirus, and dengue. CCASAnet studies will investigate non-communicable diseases such as cancer and heart disease, regional trends in the HIV epidemic and its impact on vulnerable populations, and other issues of public health importance in Latin America. Additionally, studies will address factors uniquely related to children, adolescents, and young adults with HIV. We will continue to develop and apply innovative biostatistics and informatics methods, grow our productive collaborations with other IeDEA regions, and provide leadership in the site assessment and data harmonization initiatives. Through these activities, CCASAnet 3.0 will help advance both the science of HIV epidemiology and the information science that underpins international research collaboration.