Simultaneous Hadamard Editing of GABA and Glutathione

项目总结 编辑的磁共振波谱允许对低浓度的非侵入性检测 大脑内的代谢物，如抑制性神经递质GABA和氧化还原 复合谷胱甘肽(GSH)。这些代谢物的信号在磁共振中常常重叠。 但量身定做的光谱编辑实验可以选择性地检索感兴趣的信号。 这种“编辑过的”方法通常侧重于测量单一代谢物(即GABA或 GSH)；这项提议的主要目标是开发由Hadamard编辑的 在一次采集中同时检测GABA和GSH的实验。 我们将开发Hadamard编码的Hermes方法和多体素Hadamard编辑， 使用夏尔巴人和赫尔墨斯-夏尔巴人的方法。由此产生的数据采集，后- 将提供处理和分析工具，以便分发给临床 神经科学和神经成像社区。

PROJECT SUMMARY Edited magnetic resonance spectroscopy allows the non-invasive detection of low-concentration metabolites within the brain, such as the inhibitory neurotransmitter GABA and the redox compound glutathione (GSH). The signals of such metabolites are often overlapped in the MR spectrum, but a tailored spectral editing experiment can selectively retrieve signals of interest. Such “edited” approaches generally focus on measuring a single metabolite (i.e. either GABA or GSH) in a single brain region; the main goal of this proposal is to develop Hadamard-edited experiments that detect GABA and GSH simultaneously, in a single acquisition. We will develop the Hadamard-encoded HERMES approach, and multi-voxel Hadamard editing, using the SHERPA and HERMES-SHERPA approaches. The resulting data acquisition, post- processing and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.