Building Interdisciplinary Research Careers in Women's Health

节目概要 范德比尔特BIRCWH学者计划的目标是增加准备充分的调查人员的数量 致力于通过性和性别生物学的进步来提高对妇女健康的认识。我们的目的是 将性/性别差异的研究整合到整个科学领域蓬勃发展的研究项目中， 以便为女孩和妇女实现个性化的预防、诊断和治疗。我们 建立在包括大规模卫生系统数据在内的卓越研究传统的基础上;正在进行的队列， 有几个有超过9万名参与者，如南方社区队列研究和上海妇女研究。 和男性健康研究;二十年的医疗补助数据记录链接; DNA样本与临床 超过220，000名患者的数据;强大的组织和生物标志物库和联盟访问;以及超过 50个核心，支持跨学科团队在实验室内外进行基础性发现。我们 25位前任和现任学者在狼疮的免疫学方面，性别， ICU护理结果的差异，女性和女性之间步态和假体翻修需求的差异， 男性截肢者，性激素在T细胞分化和细胞因子表达中的作用， 对痴呆症的进展和抵抗力的比较。我们所有的校友都留在科学或 行业在学术界，所有人都获得了校外奖项，其中88%获得了联邦资助，总数超过了 超过3200万美元的校外研究支持。BIRCWH学者扎根于以下基本面： 妇女健康和性别差异研究，准备领导合作小组，接受有效培训， 部署创新的跨学科方法来攻击和解决问题，并致力于追求 研究使妇女的个性化护理更接近现实。学者是通过竞争选拔出来的。 对早期职业教师的申请进行审查。培训是针对个别学者的指导下， 结构化的跨学科导师，并由PI，项目总监和副项目监督 主任（每个前BIRCWH学者）。学者们组成一个指导小组，制定个性化的职业规划， 参加每周BIRCWH工作进展报告和研讨会，接受正式评估， 每年，与其他K获奖者一起参加每月两次的职业发展研讨会系列，并定期 接触到关于负责任地进行严格和可重复研究的案例研究。他们可以获得： 1)核心阵列; 2）生物统计学咨询; 3）手稿准备小组; 4）技术编辑 完成的产品; 5）与专家一起审查科学思想，目标和研究设计的工作室; 6）校内 试点和可行性资金;和7）赠款写作支持，包括赠款研讨会，资助赠款图书馆，以及 内部研究部门。已制定工具来评估学员和导师，并不断提高 我们的计划由一个咨询委员会和两年一次的外部审查进行监督。结合这些 努力确保我们能够继续培养下一代女性健康研究人员的卓越表现。

PROGRAM SUMMARY The goal of the Vanderbilt BIRCWH Scholars Program is to increase the pool of well-prepared investigators dedicated to advancing knowledge about women's health via advances in sex and gender biology. Our intent is to integrate the study of sex/gender differences into thriving research programs across the scientific spectrum, in order to actualize personalized prevention, diagnostics, and therapeutics for girls and women. We are building on a tradition of research excellence that includes large-scale health system data; ongoing cohorts, several with more than 90,000 participants like the Southern Community Cohort Study and Shanghai Women's and Men's Health Studies; two decades of Medicaid data record linkages; DNA samples linked with clinical data for more than 220,000 patients; robust tissue and biomarker banks and consortia access; and more than 50 cores that support interdisciplinary teams making fundamental discoveries inside and outside the lab. Our 25 former and current scholars conduct research in areas as diverse as immunologic aspects of lupus, gender differences in outcomes of ICU care, differences in gait and needs for prosthetic revision among female and male amputees, role of sex hormones in T cell differentiation and cytokine expression, and patterns of progression and resistance to dementia comparing women and men. All our alumni remain in science or industry. Of those in academics, all have had extramural awards, 88% with federal funding, for a total of more than $32 million in extramural research support. BIRCWH Scholars are grounded in the fundamentals of women's health and sex differences research, prepared to lead collaborative teams, trained to effectively deploy innovative interdisciplinary approaches to attack and solve problems, and committed to pursuing research that brings individualized care for women closer to reality. Scholars are selected by competitive review of applications from among early-career faculty. Training is tailored to the individual scholar guided by structured interdisciplinary mentorship, and is overseen by the PI, Program Director and Associate Program Director (each former BIRCWH Scholars). Scholars form a mentoring panel, craft an individualized career plan, participate in weekly BIRCWH work-in-progress presentations and seminars, receive formal evaluation each year, attend twice-monthly career development seminar series with other K-awardees, and are regularly exposed to case studies on responsible conduct of rigorous and reproducible research. They have access to: 1) an array of cores; 2) biostatistics consults; 3) manuscript preparation groups; 4) technical editing of completed products; 5) studios with experts to vet scientific ideas, aims, and research designs; 6) intramural pilot and feasibility funding; and 7) grant writing support including grant workshops, a funded grant library, and internal study sections. Tools are in place to evaluate both mentees and mentors and to continuously enhance our program. Oversight is provided by an advisory committee and biennial external reviews. Combined these efforts ensure we can continue to foster excellence in the next generation of women's health researchers.