Training Program in Cancer Biology

摘要 尽管在过去的几年里，我们对细胞和分子的基本理解取得了重大突破 导致癌症的变化，致癌的许多关键步骤，以及促进早期癌症的变化 侵袭和转移，仍然没有明确的定义。严格培训未来的年轻癌症研究人员 生物学将是我们寻求对癌症发生的更深层次的理解和发展的关键 更好的癌症早期检测方法、改进的诊断和有效的癌症新疗法。这个 癌症生物学培训计划(TPCB)是一项涵盖所有癌症亚型的多学科计划 利用CU Anschutz的独特优势和培训机会，包括世界知名的研究 在功能基因组学、实验治疗学、类固醇受体信号、干细胞和器官特异性 癌症(特别是肺癌、乳腺癌、前列腺癌和血癌)。我们的目标是提供跨学科的培训 最前沿的癌症研究，为学员在生物医学研究环境中竞争做好最好的准备 越来越注重基础研究的翻译应用。我们的培训计划包括实验室 培训、教学活动、出席科学会议、专业发展和职业生涯 指导，发展沟通技能，接触临床观点。这件事的协作人 培训计划在机构内发挥领导作用，整合了科罗拉多癌症大学 中心和研究生院加入这一培训计划。克雷默博士是荷尔蒙相关中心的联席主任 癌症中心内的恶性肿瘤小组，并与其他癌症中心领导合作建立目标 以及癌症中心的方向。雷兰博士是癌症生物学博士前培训项目的负责人， 提供了与研究生院的紧密联系。其他整合来自其他培训教员，他们是 癌症中心的所有成员(许多人担任领导职务)，以及一些人也在 研究生院。来自癌症中心、研究生院和各个部门的资源是 承诺支持培训计划。癌症中心的基础设施尤其重要，因为 它为培训教员提供了核心资源，因此对受训人员是可用的。这个 拟议的计划将包括通过癌症生物学研究生培训计划进行的博士前培训， 它设在研究生院，并为博士后提供培训。共有31名培训人员 是根据他们的科学专长和指导记录挑选出来的。基于NCIS的 博士后/博士后培养比例为3：1，本次申请拟新聘博士后3名，新聘博士后1名 1年级博士后，2-5年级每年6名博士后和2名博士后。我们 将根据他们的研究和学术记录从外部和内部人才库中挑选学员，并 致力于癌症研究。我们致力于提供所有级别的全面培训，以期 最好让我们的受训人员为在学术界内外的生物医学科学领域取得成功做好准备。

ABSTRACT Despite major breakthroughs over the past few years in our basic understanding of the cellular and molecular changes that lead to cancer, many key steps in carcinogenesis, and changes in early cancers that promote invasion and metastasis, still remain poorly defined. Rigorous training of future young investigators in cancer biology will be essential in our quest for a deeper understanding of carcinogenesis, and for the development of better methods of early cancer detection, improved diagnosis, and effective new cancer treatments. The Training Program in Cancer Biology (TPCB) is a multidisciplinary program across all cancer subtypes that capitalizes on the unique strengths and training opportunities at CU Anschutz including world renown research in functional genomics, experimental therapeutics, steroid receptor signaling, stem cells and organ specific cancers (in particular lung, breast, prostate and blood). Our goal is to provide interdisciplinary training at the cutting edge of cancer research to best prepare our trainees to compete in a biomedical research environment increasingly focused on translational applications of basic research. Our training plan consists of laboratory training, didactic activities, attendance at scientific conferences, professional development and career mentoring, development of communication skills, and exposure to the clinical perspective. The Co-PIs of this training program have leadership roles within the institution that integrate the University of Colorado Cancer Center and the Graduate School into this training program. Dr. Cramer is co-director of the Hormone-Related Malignancies group within the Cancer Center and works with other Cancer Center leadership to establish goals and directions of the cancer center. Dr. Reyland is director of the Cancer Biology pre-doctoral training program, providing a strong link to the Graduate School. Additional integration comes from other training faculty who are all members of the Cancer Center (many with leadership roles), and several also have leadership roles in the Graduate School. Resources from the Cancer Center, the Graduate School, and individual departments are committed to support the training program. The infrastructure of the Cancer Center is particularly important as it provides core resources available to training faculty that are therefore available to the trainees. The proposed program will include pre-doctoral training through the graduate training program in Cancer Biology, which is housed in the Graduate School, and post-doctoral training for PhDs. The total of 31 training faculty were selected based on their scientific expertise and track record of mentorship. Based on the NCIs postdoctoral/predoctoral training ratio of 3:1, this application proposes to appoint 3 new postdocs and 1 new predoctoral student in year 1, and 6 post-docs and 2 pre-doctoral students per award year for years 2-5. We will select trainees from external and internal pools based on their research and academic records and commitment to cancer research. We are committed to providing comprehensive training at all levels so as to best prepare our trainees for successful careers in biomedical science inside or outside academia.