Training Program in Cancer Biology

摘要 尽管在过去的几年里，我们对细胞和分子的基本理解取得了重大突破， 导致癌症的变化，致癌过程中的许多关键步骤和早期癌症的变化， 侵袭和转移，仍然定义不清。严格培训未来的年轻癌症研究人员 生物学将是必不可少的，在我们寻求更深入地了解致癌作用和发展， 更好的早期癌症检测方法，更好的诊断和有效的新癌症治疗方法。的 癌症生物学培训计划（TPCB）是一个跨所有癌症亚型的多学科计划， 利用CU Anschutz的独特优势和培训机会，包括世界知名的 功能基因组学、实验治疗学、类固醇受体信号传导、干细胞和器官 特定癌症（特别是肺癌、乳腺癌和血癌）。我们的目标是提供跨学科的培训， 癌症研究的前沿，以最好地准备我们的学员在生物医学研究环境中竞争 越来越注重基础研究的转化应用。我们的培训计划包括实验室 培训、教学活动、参加科学会议、职业发展和职业生涯 指导，沟通技巧的发展，并接触到临床的角度。基于反馈 从学员和教师，为这次更新，我们增加了新的培训内容，包括强制性的 导师培训和严格性和可重复性培训。更新还包括扩大机会， 定量生物学和生物信息学培训，以及扩展的临床/转化和职业发展 机会该培训计划的合作PI一直是癌症生物学培训的领导者， 科罗拉多大学癌症中心和研究生院在过去10年。资源从 癌症中心，研究生院和个别部门致力于支持培训 程序.癌症中心的基础设施尤为重要，因为它提供了核心资源 因此，培训教师可以向受训者提供。该计划将包括预- 通过癌症生物学的研究生培训计划进行博士培训，该计划位于研究生院 学校和博士后培训博士和博士/医学博士科学家。共有38名培训教员入选 根据他们的科学专业知识和指导记录。T32赠款的第一个周期非常高， 成功的，所有的插槽竞争填补。在第二个资助周期，我们建议资助4个 博士后和4名博士前实习生每年。我们将从外部和内部人才库中挑选学员， 他们的研究和学术记录以及对癌症研究的承诺。我们致力于提供 全面的培训，以最好地准备我们的学员在生物医学事业的成功 学术界内外的科学

ABSTRACT Despite major breakthroughs over the past few years in our basic understanding of the cellular and molecular changes that lead to cancer, many key steps in carcinogenesis and changes in early cancers that promote invasion and metastasis, still remain poorly defined. Rigorous training of future young investigators in cancer biology will be essential in our quest for a deeper understanding of carcinogenesis and for the development of better methods of early cancer detection, improved diagnosis, and effective new cancer treatments. The Training Program in Cancer Biology (TPCB) is a multidisciplinary program across all cancer subtypes that capitalizes on the unique strengths and training opportunities at CU Anschutz, including world renowned research in functional genomics, experimental therapeutics, steroid receptor signaling, stem cells and organ specific cancers (in particular lung, breast and blood). Our goal is to provide interdisciplinary training at the cutting edge of cancer research to best prepare our trainees to compete in a biomedical research environment increasingly focused on translational applications of basic research. Our training plan consists of laboratory training, didactic activities, attendance at scientific conferences, professional development and career mentoring, development of communication skills, and exposure to the clinical perspective. Based on feedback from trainees and faculty, for this renewal we have added new training components, including mandatory mentor training and training in rigor and reproducibility. The renewal also includes expanded opportunities for training in quantitative biology and bioinformatics, and expanded clinical/translational and career development opportunities. The co-PIs of this training program have been leaders in Cancer Biology training at the University of Colorado Cancer Center and the Graduate School during the past 10 years. Resources from the Cancer Center, the Graduate School, and individual departments are committed to support the training program. The infrastructure of the Cancer Center is particularly important as it provides core resources available to training faculty that are therefore available to the trainees. The proposed program will include pre- doctoral training through the graduate training program in Cancer Biology, which is housed in the Graduate School, and post-doctoral training for PhD and PhD/MD scientists. A total of 38 training faculty were selected based on their scientific expertise and track record of mentorship. The first cycle of this T32 grant was highly successful, with all slots competitively filled. For the second cycle of this grant, we propose to support 4 postdoc and 4 predoctoral trainees each year. We will select trainees from external and internal pools based on their research and academic records and commitment to cancer research. We are committed to providing comprehensive training at all levels so as to best prepare our trainees for successful careers in biomedical science inside or outside academia.