Training Program in Cancer Biology

癌症生物学培训计划

• 批准号: 10670055
• 负责人: Scott D Cramer
• 金额: $ 39.44万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-07 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670055
• 关键词: Cancer Biology; Training Programs

ABSTRACT Despite major breakthroughs over the past few years in our basic understanding of the cellular and molecular changes that lead to cancer, many key steps in carcinogenesis and changes in early cancers that promote invasion and metastasis, still remain poorly defined. Rigorous training of future young investigators in cancer biology will be essential in our quest for a deeper understanding of carcinogenesis and for the development of better methods of early cancer detection, improved diagnosis, and effective new cancer treatments. The Training Program in Cancer Biology (TPCB) is a multidisciplinary program across all cancer subtypes that capitalizes on the unique strengths and training opportunities at CU Anschutz, including world renowned research in functional genomics, experimental therapeutics, steroid receptor signaling, stem cells and organ specific cancers (in particular lung, breast and blood). Our goal is to provide interdisciplinary training at the cutting edge of cancer research to best prepare our trainees to compete in a biomedical research environment increasingly focused on translational applications of basic research. Our training plan consists of laboratory training, didactic activities, attendance at scientific conferences, professional development and career mentoring, development of communication skills, and exposure to the clinical perspective. Based on feedback from trainees and faculty, for this renewal we have added new training components, including mandatory mentor training and training in rigor and reproducibility. The renewal also includes expanded opportunities for training in quantitative biology and bioinformatics, and expanded clinical/translational and career development opportunities. The co-PIs of this training program have been leaders in Cancer Biology training at the University of Colorado Cancer Center and the Graduate School during the past 10 years. Resources from the Cancer Center, the Graduate School, and individual departments are committed to support the training program. The infrastructure of the Cancer Center is particularly important as it provides core resources available to training faculty that are therefore available to the trainees. The proposed program will include pre- doctoral training through the graduate training program in Cancer Biology, which is housed in the Graduate School, and post-doctoral training for PhD and PhD/MD scientists. A total of 38 training faculty were selected based on their scientific expertise and track record of mentorship. The first cycle of this T32 grant was highly successful, with all slots competitively filled. For the second cycle of this grant, we propose to support 4 postdoc and 4 predoctoral trainees each year. We will select trainees from external and internal pools based on their research and academic records and commitment to cancer research. We are committed to providing comprehensive training at all levels so as to best prepare our trainees for successful careers in biomedical science inside or outside academia.

摘要 尽管在过去的几年里，我们对细胞和分子的基本理解取得了重大突破 导致癌症的变化，癌症发生的许多关键步骤，以及促进早期癌症的变化 侵袭和转移，仍然没有明确的定义。严格培训未来的年轻癌症研究人员 生物学将是我们寻求对癌症发生的更深层次的理解和发展的关键 更好的癌症早期检测方法、改进的诊断和有效的癌症新疗法。这个 癌症生物学培训计划(TPCB)是一项涵盖所有癌症亚型的多学科计划 利用CU Anschutz的独特优势和培训机会，包括世界知名的 功能基因组学、实验治疗学、类固醇受体信号转导、干细胞和器官研究 具体的癌症(特别是肺癌、乳腺癌和血癌)。我们的目标是提供跨学科的培训 最前沿的癌症研究，为学员在生物医学研究环境中竞争做好最好的准备 越来越注重基础研究的翻译应用。我们的培训计划包括实验室 培训、教学活动、出席科学会议、专业发展和职业生涯 指导，发展沟通技能，接触临床观点。基于反馈 在学员和教职员工中，我们为此次续订增加了新的培训内容，包括必修课 导师培训以及严谨和可重复性方面的培训。续订还包括以下扩展的机会 数量生物学和生物信息学方面的培训，以及扩大临床/翻译和职业发展 机遇。该培训计划的合作PI一直是 科罗拉多大学癌症中心和研究生院在过去的10年里。资源来自 癌症中心、研究生院和个别部门致力于支持培训 程序。癌症中心的基础设施尤其重要，因为它提供核心资源 可供培训教员使用，因此可供受训人员使用。拟议的计划将包括预 通过癌症生物学研究生培训计划进行博士培训，该计划设在研究生 为博士和博士/医学博士科学家提供学校和博士后培训。共有38名培训教师入选。 基于他们的科学专业知识和指导记录。这笔T32赠款的第一个周期是高度 成功，所有的职位都竞争激烈地填补了。对于这笔赠款的第二个周期，我们建议支持4 每年博士后和博士后实习生4人。我们将从外部和内部人才库中挑选学员 关于他们的研究和学术记录以及对癌症研究的承诺。我们致力于提供 所有级别的全面培训，为学员在生物医学领域的成功职业生涯做好最佳准备 学术界内外的科学。

项目成果

Src-mediated regulation of the PI3K pathway in advanced papillary and anaplastic thyroid cancer.

• DOI: 10.1038/s41389-017-0015-5
• 发表时间: 2018-02-28
• 期刊: Oncogenesis
• 影响因子: 6.2
• 作者: Beadnell TC;Nassar KW;Rose MM;Clark EG;Danysh BP;Hofmann MC;Pozdeyev N;Schweppe RE
• 通讯作者: Schweppe RE

Androgen Receptor Signaling in Prostate Cancer Genomic Subtypes.

• DOI: 10.3390/cancers13133272
• 发表时间: 2021-06-30
• 期刊: Cancers
• 影响因子: 5.2
• 作者: Jillson LK;Yette GA;Laajala TD;Tilley WD;Costello JC;Cramer SD
• 通讯作者: Cramer SD

Dissecting stepwise mutational impairment of megakaryopoiesis in a model of Down syndrome-associated leukemia.

• DOI: 10.1172/jci161659
• 发表时间: 2022-07-15
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Evans, Edward J., Jr.;DeGregori, James
• 通讯作者: DeGregori, James

CD38 antibody re-treatment in daratumumab-refractory multiple myeloma after time on other therapies.

• DOI: 10.1182/bloodadvances.2023010162
• 发表时间: 2023-11-14
• 期刊: BLOOD ADVANCES
• 影响因子: 7.5
• 作者: de Acha, Olivia Perez;Reiman, Lauren;Jayabalan, David S.;Walker, Zachary J.;Bosma, Grace;Keller, Alana L.;Parzych, Sarah E.;Abbott, Diana;Idler, Beau M.;Ribadeneyra, Drew;Niesvizky, Ruben;Forsberg, Peter A.;Mark, Tomer M.;Sherbenou, Daniel W.
• 通讯作者: Sherbenou, Daniel W.

Harnessing a Different Dependency: How to Identify and Target Androgen Receptor-Positive Versus Quadruple-Negative Breast Cancer.

• DOI: 10.1007/s12672-017-0314-5
• 发表时间: 2018-04
• 期刊: Hormones & cancer
• 影响因子: 3
• 作者: Christenson JL;Trepel JB;Ali HY;Lee S;Eisner JR;Baskin-Bey ES;Elias AD;Richer JK
• 通讯作者: Richer JK