Training Program in Cancer Biology

癌症生物学培训计划

• 批准号: 10670055
• 负责人: Scott D Cramer
• 金额: $ 39.44万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-07 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670055
• 关键词: Cancer Biology; Training Programs

ABSTRACT Despite major breakthroughs over the past few years in our basic understanding of the cellular and molecular changes that lead to cancer, many key steps in carcinogenesis and changes in early cancers that promote invasion and metastasis, still remain poorly defined. Rigorous training of future young investigators in cancer biology will be essential in our quest for a deeper understanding of carcinogenesis and for the development of better methods of early cancer detection, improved diagnosis, and effective new cancer treatments. The Training Program in Cancer Biology (TPCB) is a multidisciplinary program across all cancer subtypes that capitalizes on the unique strengths and training opportunities at CU Anschutz, including world renowned research in functional genomics, experimental therapeutics, steroid receptor signaling, stem cells and organ specific cancers (in particular lung, breast and blood). Our goal is to provide interdisciplinary training at the cutting edge of cancer research to best prepare our trainees to compete in a biomedical research environment increasingly focused on translational applications of basic research. Our training plan consists of laboratory training, didactic activities, attendance at scientific conferences, professional development and career mentoring, development of communication skills, and exposure to the clinical perspective. Based on feedback from trainees and faculty, for this renewal we have added new training components, including mandatory mentor training and training in rigor and reproducibility. The renewal also includes expanded opportunities for training in quantitative biology and bioinformatics, and expanded clinical/translational and career development opportunities. The co-PIs of this training program have been leaders in Cancer Biology training at the University of Colorado Cancer Center and the Graduate School during the past 10 years. Resources from the Cancer Center, the Graduate School, and individual departments are committed to support the training program. The infrastructure of the Cancer Center is particularly important as it provides core resources available to training faculty that are therefore available to the trainees. The proposed program will include pre- doctoral training through the graduate training program in Cancer Biology, which is housed in the Graduate School, and post-doctoral training for PhD and PhD/MD scientists. A total of 38 training faculty were selected based on their scientific expertise and track record of mentorship. The first cycle of this T32 grant was highly successful, with all slots competitively filled. For the second cycle of this grant, we propose to support 4 postdoc and 4 predoctoral trainees each year. We will select trainees from external and internal pools based on their research and academic records and commitment to cancer research. We are committed to providing comprehensive training at all levels so as to best prepare our trainees for successful careers in biomedical science inside or outside academia.

抽象的 尽管在过去的几年中，我们对细胞和分子的基本理解有了重大突破 导致癌症的变化，癌变的许多关键步骤以及早期癌症的变化 入侵和转移，仍然定义很差。严格培训未来的癌症年轻调查员 生物学对于我们寻求对癌变和发展的发展至关重要 更好的早期癌症检测方法，改善诊断和有效的新癌症治疗方法。这 癌症生物学培训计划（TPCB）是所有癌症亚型的多学科计划 利用Cu Anschutz的独特优势和训练机会，包括世界知名 功能基因组学，实验疗法，类固醇受体信号，干细胞和器官的研究 特定的癌症（尤其是肺，乳房和血液）。我们的目标是在 癌症研究的尖端，以最好地准备我们的学员在生物医学研究环境中竞争 越来越多地专注于基础研究的翻译应用。我们的培训计划包括实验室 培训，教学活动，参加科学会议，专业发展和职业 指导，沟通技巧的发展以及接触临床观点。基于反馈 从学员和教师那里，对于此续签，我们添加了新的培训组件，包括强制性 严格和可重复性的导师培训和培训。续约还包括扩大的机会 培训定量生物学和生物信息学，并扩大了临床/转化和职业发展 机会。该培训计划的共同点一直是癌症生物学培训的领导者 在过去的10年中，科罗拉多大学癌症中心和研究生院。来自 癌症中心，研究生院和各个部门致力于支持培训 程序。癌症中心的基础设施特别重要，因为它提供了核心资源 因此，可供受训人员使用的培训教师。拟议的计划将包括前 通过癌症生物学研究生培训课程的博士培训，该课程位于研究生中 学校和博士学位和博士/MD科学家的博士后培训。总共选择了38个培训教师 根据他们的科学专业知识和指导的记录。 T32赠款的第一个周期很高 成功，所有插槽都有竞争力填充。对于这笔赠款的第二个周期，我们建议支持4 每年的博士后和4名托管学员。我们将从外部和内部池中选择学员 关于他们的研究和学术记录以及对癌症研究的承诺。我们致力于提供 各个级别的全面培训，以最好地为我们的学员准备成功的生物医学职业 科学在学术界内或外部。

项目成果

Src-mediated regulation of the PI3K pathway in advanced papillary and anaplastic thyroid cancer.

• DOI: 10.1038/s41389-017-0015-5
• 发表时间: 2018-02-28
• 期刊: Oncogenesis
• 影响因子: 6.2
• 作者: Beadnell TC;Nassar KW;Rose MM;Clark EG;Danysh BP;Hofmann MC;Pozdeyev N;Schweppe RE
• 通讯作者: Schweppe RE

Androgen Receptor Signaling in Prostate Cancer Genomic Subtypes.

• DOI: 10.3390/cancers13133272
• 发表时间: 2021-06-30
• 期刊: Cancers
• 影响因子: 5.2
• 作者: Jillson LK;Yette GA;Laajala TD;Tilley WD;Costello JC;Cramer SD
• 通讯作者: Cramer SD

Dissecting stepwise mutational impairment of megakaryopoiesis in a model of Down syndrome-associated leukemia.

• DOI: 10.1172/jci161659
• 发表时间: 2022-07-15
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Evans, Edward J., Jr.;DeGregori, James
• 通讯作者: DeGregori, James

CD38 antibody re-treatment in daratumumab-refractory multiple myeloma after time on other therapies.

• DOI: 10.1182/bloodadvances.2023010162
• 发表时间: 2023-11-14
• 期刊: BLOOD ADVANCES
• 影响因子: 7.5
• 作者: de Acha, Olivia Perez;Reiman, Lauren;Jayabalan, David S.;Walker, Zachary J.;Bosma, Grace;Keller, Alana L.;Parzych, Sarah E.;Abbott, Diana;Idler, Beau M.;Ribadeneyra, Drew;Niesvizky, Ruben;Forsberg, Peter A.;Mark, Tomer M.;Sherbenou, Daniel W.
• 通讯作者: Sherbenou, Daniel W.

Harnessing a Different Dependency: How to Identify and Target Androgen Receptor-Positive Versus Quadruple-Negative Breast Cancer.

• DOI: 10.1007/s12672-017-0314-5
• 发表时间: 2018-04
• 期刊: Hormones & cancer
• 影响因子: 3
• 作者: Christenson JL;Trepel JB;Ali HY;Lee S;Eisner JR;Baskin-Bey ES;Elias AD;Richer JK
• 通讯作者: Richer JK