THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE

项目摘要 NIA建立了阿尔茨海默病国家衰老遗传学研究所数据存储网站 (NIAGADS)作为国家遗传学数据库，以便利合格的研究人员访问 晚发性阿尔茨海默病(AD)遗传学研究的基因分型数据。这是NIA的政策 所有来自NIA资助的迟发性阿尔茨海默病遗传学研究的基因数据 尽可能存放在NIAGADS或其他NIA批准的地点或两者都有。NIAGADS也是数据 阿尔茨海默病测序项目协调中心(ADSP)，这是白宫/NIH的一项倡议，旨在 通过对大约15,000名认知正常的AD患者的基因组/外显子进行测序来识别新的遗传变异 控制。在第二个资助期，NIAGADS将继续其作为AD国家储存库的任务 遗传学与这些拟议的活动：(1)接收和组织AD遗传学数据集，以供社区访问， (2)协调ADSP的数据生产和支持分析活动；(3)发展AD基因组学 信息门户(AD-GIG)，为研究人员获取AD知识的综合信息平台， NIAGADS的数据和其他资源更轻松，(4)通过与其他资源的接口扩展NIAGADS资源 研究倡议，以及(5)通过积极的外展计划促进社区参与。

Project Summary NIA has established the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) as a national genetics data repository in order to facilitate access by qualified investigators to genotypic data for the study of the genetics of late-onset Alzheimer's Disease (AD). It is the policy of the NIA that all Genetic Data derived from NIA funded studies for the genetics of late-onset Alzheimer's disease be deposited at NIAGADS or another NIA approved site or both whenever possible. NIAGADS is also the Data Coordinating Center for Alzheimer's Disease Sequencing Project (ADSP), a White House/NIH initiative to identify new genetic variants by sequencing genomes/exomes of ~15,000 AD patients and cognitively normal controls. In the second funding period, NIAGADS will continue its mission as the national repository for AD genetics with these proposed activities: (1) receive and organize AD genetics datasets for community access, (2) coordinate data production and support analysis activities for ADSP, (3) develop the AD Genomics Information Gateway (AD-GIG), an integrated information platform for researchers to access AD knowledge, data, and other resources at NIAGADS more easily, (4) expand NIAGADS resource by interfacing with other research initiatives, and (5) promote community involvement with an active outreach program.