Cancer Epidemiology Cohort in Male Health Professionals

项目总结 此竞争续订应用程序的目标是支持核心基础架构和持续跟进 卫生专业人员跟踪研究(HPFS)，癌症流行病学队列(CEC)，成立于1986年 其中包括51529名基线年龄在40岁至75岁之间的男性卫生专业人员。这一群体是独一无二的 重点关注男性的健康和近30年的随访，这一时间框架对于现实来说是必不可少的 了解可改变因素与癌症风险之间的关系。在这段时间里，数据一直在 定期更新饮食、活动、吸烟、体重、药物和其他潜在的可改变的决定因素 癌症风险。已经建立了一个广泛的生物库，其中包括大多数参与者的DNA， 脚趾甲、红细胞和血浆。肿瘤组织取自高比例的前列腺癌 和结直肠癌；最近的一项补充支持收集不太常见的肿瘤和 非癌性前列腺组织。在每两年的周期中，队列随访一直保持在90%或更高 死亡追踪几乎已经完成。HPFS的流行病学研究，单独和 参与联合体，有助于阐明癌症发病率的风险因素和癌症的决定因素 在男人身上生存。随着队列成员现在处于癌症高发年龄，HPFS正处于高度 生产阶段。在本供资周期内，发表了325篇利用数据和/或 来自HPFS的生物样本；其中200个样本专门检查了癌症或癌症先兆结果。 到目前为止，已有13,346名参与者被诊断出患有癌症，有3,571人死于癌症；5791人 HPFS中的男性目前患有癌症。在下一个资金周期中，我们提出以下建议 目标。1)继续积极跟踪癌症发病率和死亡率，并在 癌症确诊后。2)更新食物成分数据库，以支持#年的膳食评估 HPFS和护士健康研究I和II队列。3-)利用最近完成的验证研究 体力活动，并与两个多民族男性队列中的同事合作，以校准体力活动 问题。4-)首次链接到联邦医疗保险索赔数据。5)维护HPFS癌组织 生物库，并扩大前列腺癌和结肠癌的收集范围，并在 非吸烟者。6)维护其他生物库，包括血浆、红细胞、生殖系DNA和 脚趾甲样本。7)在前列腺癌患者中进行新的诊断后血液采集。8-) 维持和加强该队列的统计基础设施和数据管理。9-)促进 与其他CEC和外部调查人员的资源共享和协作。随着其他队列的跟进- UP，特别是在癌症诊断后，HPFS仍然是做出创新贡献的理想位置 我们的总体目标是通过确定一级和二级预防战略来减轻癌症负担。

PROJECT SUMMARY The goal of this competing renewal application is to support the core infrastructure and continued follow-up of the Health Professionals Follow-up Study (HPFS), a cancer epidemiology cohort (CEC) established in 1986 and including 51,529 male health professionals age 40 to 75 years at baseline. This cohort is unique in its focus on men's health and follow-up of almost three decades, a time frame that is essential to realistically understand the relation between modifiable factors and cancer risk. Over this period of time, data has been regularly updated on diet, activity, smoking, weight, medications, and other potentially modifiable determinants of cancer risk. An extensive biorepository has been established that includes DNA from most participants, toenails, red cells, and plasma. Tumor tissue has been obtained from a high percentage of incident prostate and colorectal cancers; a recent supplement is supporting collection of tissue for less common tumors and noncancerous prostate tissue. Cohort follow-up has been consistently 90% or higher at each two-year cycle and mortality follow-up is virtually complete. Epidemiological studies from the HPFS, alone and through participation in consortia, have helped elucidate risk factors for cancer incidence and determinants of cancer survival in men. With cohort members now in an age of high cancer incidence, the HPFS is in a highly productive phase. During the current funding cycle, 325 papers have been published that utilize data and/or biological samples from HPFS; 200 of these have specifically examined cancer or cancer precursor outcomes. To date, 13,346 participants have been diagnosed with cancer and 3,571 cancer deaths have occurred; 5,791 men in HPFS are currently living with a cancer diagnosis. In the next funding cycle, we propose the following aims. 1-) To continue active follow-up for cancer incidence and mortality and to update exposure data pre and post-diagnosis of cancer. 2-) To update the food composition database that supports dietary assessment in HPFS and the Nurses' Health Study I and II cohorts. 3-) To leverage a recently completed validation study of physical activity and collaborate with colleagues in two multiethnic cohorts of men to calibrate physical activity questions. 4-) To make a first time linkage to Medicare Claims data. 5-) To maintain the HPFS cancer tissue biorepository, and expand collections of prostate and colon, and undertake a new collection of lung cancer in nonsmokers. 6-) To maintain the other biorepositories including plasma, red blood cells, germline DNA, and toenail samples. 7-) To undertake a new post-diagnostic blood collection among men with prostate cancer. 8-) To maintain and augment the statistical infrastructure and data management of the cohort. 9-) To facilitate resource sharing and collaborations with other CECs and outside investigators. With additional cohort follow- up, particularly after cancer diagnosis, the HPFS remains ideally positioned to make innovative contributions to our overall goal of reducing the burden of cancer by identifying primary and secondary prevention strategies.