South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE)

 描述（由申请人提供）：南卡罗来纳州IDEA生物医学研究卓越网络（SC INBRE）是一个由三所综合研究型大学（CRU）和七所主要本科院校（PUI）组成的网络，这些大学在过去的资助期内一直在共同努力，以追求共同的目标：建立生物医学研究基础设施，加强南卡罗来纳州的本科生研究培训，并促进所有学生获得健康研究职业，特别是代表性不足的少数群体和经济上处于不利地位的群体。SC INBRE的主题领域目前是生物工程/再生医学（主要在CRU）和细胞和分子生物学（主要在PUI）。此外，神经科学已经成为下一阶段建立的另一个优势领域。我们也看到了生物信息学在研究主题领域和学生培训中的应用有很大增长，这要归功于 生物信息学核心的努力。SC INBRE在当前供资期间取得了巨大成功。自2009年以来，在接受研究培训的387名学生中，172名为男性，215名为女性，超过33%的学生是代表性不足的少数民族。在196名已经进入研究生职业生涯的学生中，46%的人去了研究生院，22%的人去了医学/专业学校，27%的人在工业界工作。在当前的资助期间，SC INBRE教师和学生制作了170多份出版物和300多份演讲，并从包括NIH和NSF在内的各种资金来源获得了总计超过3600万美元的额外赠款支持。SC INBRE为大型机构（HHMI）和中心赠款（COBRE）的申请铺平了道路并提供了支持，这些补助金为该州带来了超过1300万美元的研究资金。长期以来一直是SC INBRE成员的PUI是网络中新机构的榜样。在新的资助期内，我们建议通过在网络中加入新的PUI，并通过进一步增加网络活动和跨机构的连接，将SC INBRE的支持范围扩大到全州的教师和学生。为此，我们将实施发展研究项目（DRP）Pr，并为DRP目标教师提供强大的指导和培训以及职业发展机会;我们将通过机构SC INBRE本科研究计划扩大每个网络PUI的学生的研究培训;我们将通过扩大试点项目计划增加生物信息学核心的活动。我们会翻新三所理工学院的研究设施。对选定地点的高中教师和学生的宣传将有助于提高学生的认识，加强SC INBRE的研究职业管道，积极鼓励和支持代表性不足的少数民族学生和来自服务不足地区的学生接受大学教育并从事生物医学研究。

 DESCRIPTION (provided by applicant): The South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE) is a network of three Comprehensive Research Universities (CRU) and seven Predominantly Undergraduate Institutions (PUI) that have been working together during the past funding periods in pursuit of their common goals: to build biomedical research infrastructure and strengthen undergraduate research training in South Carolina, and to promote access to health research careers for all students, particularly underrepresented minorities and economically disadvantaged groups. The thematic areas of SC INBRE are currently Bioengineering/ Regenerative Medicine (primarily at the CRUs) and Cell and Molecular Biology (mostly at the PUI). In addition, Neuroscience has emerged as an additional area of strength upon which to build in the next phase. We have also seen much growth in the utilization of Bioinformatics within the research thematic areas and in student training, thanks to the efforts of the Bioinformatics Core. SC INBRE enjoyed tremendous success during the current funding period. Of the 387 students that received research training sine 2009, 172 were Males, 215 Females, and over 33% were Underrepresented Minorities. Of the 196 students who are well into their post-graduate careers, 46% went to graduate school, 22% to medical/professional school, and 27% hold industry jobs. In the current funding period, SC INBRE faculty and students produced over 170 publications and over 300 presentations, and generated additional grant support for a total of over $36 Million from a variety of funding sources including the NIH and the NSF. SC INBRE paved the way for and supported the preparation of applications for large institutional (HHMI) and Center grants (COBRE) that (all together) brought over $13 Million in research funds to the state. PUIs that have been long-time members of SC INBRE serve as role models to new institutions in the network. In the new funding period we propose to extend the reach ofSC INBRE's support to faculty and students across the state by including new PUIs in the network, and by further increasing network activities and connec across institutions. To this end, we will implement the Developmental Research Project (DRP) Pr complemented by strong mentoring and training and career development opportunities for the DRP target faculty; we will expand research training of students at each network PUI through the Institutional SC INBRE Undergraduate Research Programs; and we will increment the activities of the Bioinformatics Core with an expanded Pilot Projects program. We will renovate research facilities at three PUIs. Outreach to high school teachers and students at selected sites will help tions ogram, strengthen SC INBRE's pipeline to research careers that actively encourages and supports underrepresented minority students and students from underserved areas to pursue a college education and engage in biomedical research.