Mechanisms of Disease & Translational Science

描述（由申请人提供）：疾病和转化科学博士培训轨道（MOD）在UT西南研究生院的机制将培养博士生的精英群体成为下一代的翻译科学家的领导者。研究生院的基础科学系（DBS）和临床科学系（DCS）将合作，为学生提供在基础科学和临床科学之间研究人类疾病的新机会。国防部的主要目标是培养一批新的博士水平的科学家，他们能够针对自己的研究项目，以解决未来未满足的治疗和诊断需求。基本原理：转化研究发生在从实验室到床边和背部的连续体中，从事翻译早期阶段（T1）的博士生必须在现代分子方法以及人类生理学和病理学方面有基础。他们还必须学会在基于团队的临床研究环境中导航，并与临床医生沟通。为了实现这些目标，我们设计了国防部作为一个补充轨道，覆盖在现有的十个DBS博士研究生课程。通过这种方式，我们协同和补充现有的计划，并专注于创造一个新的培训模式。国防部独特的培训课程旨在提高翻译能力，现有课程中没有。除了开发国防部教学课程，国防部还利用DCS丰富的临床和转化教育资源，提供患者护理和临床研究方面的结构化经验，并接触到桥接基础课程和教学课程的机遇和挑战。学员：我们寻求T32资助，以支持6个博士前博士生在第1年和第2年，并在随后的几年7。国防部的任命是由DBS学生谁是在竞争的基础上完成研究生培训的第一年。持续时间：拟议培训的持续时间为16个月，尽管国防部田径学生继续与该计划有关。我们只要求为每个学生提供12个月的T32支持，以便每年能够任命恒定数量的新学生。预期结果：国防部轨道提供了独特的机会和严格的培训，以填充早期的T1转化研究连续体，和T32资金将使我们能够进一步改善和扩大我们的努力，培养博士转化科学家。国防部的学生将配备“智力”和“实用”工具包，以带头双向传播的发现，以改善人类健康。国防部的计划具有创新性、可持续性和成本效益。它独特地利用现有的机构优势，创造一个新的翻译科学培训计划，补充校园内其他计划的研究和教育使命。它非常成功，我们预计，随着新的T32资金的投入，它将对转化生物医学劳动力的产生产生重大影响。

DESCRIPTION (provided by applicant): The Mechanisms of Disease and Translational Science PhD Training Track (MoD) at the UT Southwestern Graduate School will train an elite group of PhD students to become the leaders of the next generation of translational scientists. The Graduate School's Divisions of Basic Science (DBS) and Clinical Science (DCS) will collaborate to provide students with new opportunities to study human diseases at the interface between basic and clinical sciences. MoD's primary goal is to create a new breed of PhD-level scientists capable of targeting their research programs to address unmet therapeutic and diagnostic needs of the future. Rationale: Translational research occurs in a bench to bedside & back continuum, and PhD students who engage in the early phase of translation (T1) must have a foundation in modern molecular approaches as well as in human physiology and pathology. They will also have to learn to navigate the team based clinical research environment and to communicate with clinicians. To accomplish these goals, we designed MoD as a supplemental track that is overlaid on the ten existing DBS PhD graduate programs. In this way, we synergize and complement existing programs, and are focused on creating a new training paradigm. MoD's unique training curriculum is designed to increase translational competencies and is not available in existing programs. In addition to developing MoD didactic courses, MoD has leveraged the rich clinical and translational education resources of DCS to offer structured experiences in patient care and clinical research and exposures to the opportunities and challenges of bridging basic and didactic courses. Trainees: We seek T32 funding to support 6 predoctoral PhD students in years 1 and 2, and 7 in subsequent years. MoD appointments are made to DBS students who are completing the first year of graduate training on a competitive basis. Duration: The duration of proposed training is for 16 months, although MoD track students continue to be associated with the program. We are only asking 12 months of T32 support for each student, in order to be able to appoint a constant number of new students each year. Anticipated Outcomes: The MoD Track provides unique opportunities and rigorous training to populate the early T1 translational research continuum, and T32 funding will allow us to further improve and expand our efforts to train PhD translational scientists. MoD students will be equipped with the "intellectual" and "practical" toolkits to spearhead the bidirectional translatio of discoveries to improve human health. The MoD plan is innovative, sustainable and cost-effective. It uniquely exploits existing institutional strengths to create a novel translational science training program that complements the research and educational mission of other programs on campus. It has been very successful and we anticipate that with new T32 funding it will have significant impact in the generation of a translational biomedical workforce.