The Cleveland Digestive Diseases Research Core Center (DDRCC)

描述（由申请人提供）：此修订后的申请正在提交，以获得克利夫兰消化系统疾病研究核心中心（DDRCC）的资金，这是凯斯西储大学（CWRU）和克利夫兰诊所基金会（CCF）之间的联合努力。克利夫兰DDRCC是一个跨机构和多学科的计划，包括来自15个不同学术部门的34名正式成员和18名准成员。该中心的两个主要主题是消化道炎症和代谢，这两个都代表了CWRU和CCF合作研究的成熟领域。拟议的克利夫兰复员方案协调中心将：1）增强中心研究者的基础研究能力，2）制定和实施计划，以支持年轻研究者在消化道炎症和代谢研究中的独立发展，3）吸引目前未参与消化道疾病研究的具有各种专业知识的成熟研究者将其专业知识应用于这一重要的研究领域，（4）促进基础研究成果向临床竞技场的转化。我们有强大的机构支持，包括130万美元的初始投资，以增加消化系统疾病研究在两个机构的影响。该中心的研究基础包括1500万美元的联邦赠款（48 NIH，1 DOD，1 VA，1 NSF），专门与消化道炎症和代谢有关，其中51%的资金直接来自NIDDK（760万美元）。我们提出了3个科学核心来支持这个强大的研究基础：1）BioRepository核心，2）组织学/成像核心，3）小鼠模型核心。这些核心实验室与一个组织良好的行政核心接口，该核心还支持试点/可行性和命名新研究者计划，以促进新进入消化系统疾病领域的研究人员的创新研究项目。行政核心还包括一个充实计划和一个临床组成部分，并监督克利夫兰DDRCC的财务管理和运作。克利夫兰DDRCC的总体目标是增加中心成员的核心资源的可用性，并促进研究，合作和消化系统疾病研究的新方向。

DESCRIPTION (provided by applicant): This revised application is being submitted to obtain funding for the Cleveland Digestive Diseases Research Core Center (DDRCC), which is a combined effort between Case Western Reserve University (CWRU) and the Cleveland Clinic Foundation (CCF). The Cleveland DDRCC is a cross-institutional and multi-disciplinary program, including 34 full members and 18 associate members from 15 different academic departments. The Center's two major themes are Digestive Inflammation and Metabolism, both of which represent well established areas of collaborative investigation at CWRU and the CCF. The proposed Cleveland DDRCC will: 1) enhance the basic research capabilities of Center investigators, 2) develop and implement programs to support the independent development of young investigators in Digestive Inflammation and Metabolism research, 3) attract established investigators with varied expertise who are not currently involved in digestive disease research to apply their expertise to this important area of investigation, and 4) facilitate the translationof basic research discoveries to the clinical arena. We have strong institutional support, including an initial investment of $1.3 million to increase the impact of digestive disease research at both institutions. The Research Base for the Center consists of $15 0 million in federal grants (48 NIH, 1 DOD, 1 VA, 1 NSF) specifically related to Digestive Inflammation and Metabolism, with 5 1% of these funds coming directly from the NIDDK ($7.6 million). We are proposing 3 scientific cores to support this strong Research Base: 1) BioRepository Core, 2) Histology/Imaging Core, and 3) Mouse Models Core. These core laboratories interface with a well-organized Administrative Core, which also supports Pilot/Feasibility and Named New Investigator Programs to promote innovative research projects by investigators who are new to the area of digestive diseases. The Administrative Core also includes an Enrichment Program and a Clinical Component, and oversees the financial management and operation of the Cleveland DDRCC. The overall objective of the Cleveland DDRCC is to increase the availability of core resources for Center members, and foster research, collaborations, and new directions in digestive disease research.