Improving UC Davis MMRRC Services by Improving Infrastructure to Cultivate a "Green Vivarium" while Optimizing Pathogen Exclusion and Animal Health

摘要 为了更好地支持我们老化的的需求，位于 加州大学戴维斯分校(MMRRC-UCD)致力于改善我们内部的基础设施和设备 M3高级鼠障设施。作为突变小鼠模型的主要分销商，我们的基础设施 屏障是影响我们生产和分发的动物的健康和福祉的关键因素 全球，目前服务于41个国家。MMRRC-UCD是NIH资助的四个中心中最大的一个 协会，专门从事有价值的突变小鼠模型的冷冻保存和分发。在……里面 不断努力提高我们的运营效率我们已经分析了阻碍我们 优化生产，并确定了一个关键因素是设备老化和陈旧。较老的动物舍和 程序设备会导致增加能源和水的使用，此外还会产生过大的噪音和 与更先进的现代化技术相比，振动都会增加动物的压力。 因此，动物生产可能会受到影响，运营成本也会增加。实验室 动物界一直大力倡导“3R”的替代、减量和 精致。然而，我们现在所处的时代，我们也必须倡导我们所设想的“5E”： 效率、排他性、人体工程学、丰富和教育。我们的目标是改善 我们的屏障设施，通过实施精益管理原则，强调环境资源 使用我们创新的5E方法。目前的提案要求提供资金来升级过时的动物转移 M3屏障设施中的车站和生物安全柜。此外，我们将停止使用水 瓶子作为动物的水源，改用AqupacTM袋子提供无菌水 来源，从而减少病原体的风险和减少使用的环境资源。MMRRC- UCD致力于有利地整合创新概念，以实现更高的效率、排他性和人体工程学 Varium的设计将我们的标准啮齿动物屏障设施改造成最先进的Lean- 绿色动物研究机构，以指导其他机构使我们的原则能够在全球范围内应用。

Abstract To better support the needs of our aging vivarium, the Mutant Mouse Resource and Research Center at the University of California, Davis (MMRRC-UCD) is driven to improve the infrastructure and equipment within our M3 high-level rodent barrier facility. As a premier distributor of mutant mouse models, the infrastructure of our barrier is a critical factor influencing the health and well-being of the animals we produce and distribute worldwide, currently serving 41 countries. The MMRRC-UCD is the largest center of the four NIH-funded consortiums, and specializes in the cryopreservation and distribution of valuable mutant mouse models. In continued efforts to improve the efficiencies of our operations we have analyzed the deficiencies hindering our optimal production and identified a key factor being aged and outdated equipment. Older animal housing and procedure equipment can lead to increased energy and water use, in addition to excessive noise and vibrations compared to more advanced modernized technologies, all leading to increase stress to the animal. As a result, animal production may be compromised and the costs of operations increased. The laboratory animal community has been strong advocates to promote the “3R’s” being Replacement, Reduction and Refinement. However, we are now in an era when we must also advocate for what we envision as the “5E’s”: Efficiencies, Exclusion, Ergonomics, Enrichment, and Education. Our goal is to improve the infrastructure at our barrier facility by implementing lean management principles with an environmentally resourceful emphasis using our innovative 5E’s approach. The current proposal requests funds to upgrade outdated animal transfer stations and biosafety cabinet in the M3 Barrier Facility. Additionally, we will discontinue the use of water bottles as a water source for the animals and convert to using HydropacTM pouches to provide a sterile water source, thus reducing the risk of pathogens and decreasing the environmental resources used. The MMRRC- UCD strives to advantageously integrate innovative concepts for higher efficient, exclusive and ergonomic vivarium designs to transform our standard rodent barrier facility into a state of the art prototype of a Lean- Green animal research facility, to guild other institutions to enable our principles to be applied globally.