Universal Edited MRS at 3T

项目总结 许多具有生物化学意义的分子，包括抑制性和兴奋性神经递质 GABA和天冬氨酸，氧化还原化合物谷胱甘肽和抗坏血酸，以及神经调节剂N- 利用编辑的~1H磁共振仪可无创测定人脑中的乙酰天冬氨酸谷氨酸 共振光谱学(MRS)。直到最近，编辑后的MRS还被用作单一的变质沸石 单体素方法-即需要10分钟采集来测量GABA，以及其他 测试其他代谢物的实验。这在很大程度上限制了 在临床研究中编辑的MRS，特别是关于例如不同的 系统。这笔赠款的总体目标是开发一种通用的采集和处理 用于测量人脑中所有这些可编辑代谢物水平的管道 做实验。 我们将开发单个序列，在所有三个主要供应商平台上实现，用于多路传输 编辑3T，Gannet定量数据分析工具包，并演示跨平台 新度量的等价性。由此产生的数据采集和分析工具将 可向临床神经科学和神经成像社区传播。

PROJECT SUMMARY Many biochemically interesting molecules, including the inhibitory and excitatory neurotransmitters GABA and aspartate, the redox compounds glutathione and ascorbate, and the neuromodulator N- acetylaspartylglutamate can be measured in the human brain non-invasively using edited 1H magnetic resonance spectroscopy (MRS). Until very recently, edited MRS has been applied as a single-metbaolite single-voxel method – i.e. requiring a 10-minute acquisition to measure GABA, and additional experiments to measure other metabolites. This has substantially limited the breadth of application of edited MRS in clinical studies, and particularly studies of, for example, interactions between different systems. The overall goal of this grant is the development of a universal acquisition and processing pipeline for measuring levels of all these editable metabolites in the human brain from a single experiment. We will develop a single sequence, implemented on all three major vendor platforms, for multiplexed editing 3T, the Gannet Toolkit for quantitative data analysis, and demonstrate the cross-platform equivalence of the new measurement. The resulting data acquisition and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.