2019 Cardiac Arrhythmia Mechanisms GRC/GRS

总结 心律失常是猝死和中风的主要原因。在阐明 分子，细胞和系统水平的机制，促进了新的概念，指导了 制定更有效的诊断和治疗策略。然而，心律失常仍然存在， 世界各地发病率和死亡率的主要原因，以及突破基本保健界限的必要性 推动翻译的科学发现从未如此紧迫。2019年戈登研究 心脏心律失常机制会议（GRC）旨在促进科学进步， 这一令人不安的公共卫生问题，通过组装一个跨学科的计划，以激励和推动该领域 通过强调理解心律失常生物学的多尺度挑战， 多学科的研究方法，并具有新兴的治疗范例。这一既定 两年一次的会议被广泛认为是最重要的论坛，其中尖端的概念和新的 对心脏节律紊乱的机制和治疗进行了观察。会议将 汇集了许多相关领域的国际专家和受训人员，包括遗传学、基础教育、 电生理学、结构生物学、生物物理学、生物医学工程、计算机科学和临床 心脏病学在非正式的气氛中互动，并分享有关正常和 心律失常，包括心脏性猝死和中风的原因。该计划包括 心律失常生物学的当前和新兴思想领袖，来自互补科学研究的研究人员， 学科，学员和新的研究人员与有前途的职业生涯。会议的一个目标是提供 为初级、中级和高级调查人员提供一个论坛， 心律失常机制领域的进展，以弥合基础科学与临床之间的差距 应用程序，以刺激新的合作领域，以促进合议和信息共享。的 会议将鼓励和促进学员的职业发展，支持相关戈登 研究研讨会（GRS），学员在研讨会上介绍他们的研究成果并进行小组讨论 在职业道路和专业发展方面与导师进行交流。主旨发言强调， 科学的严谨性和科学的可重复性的重要性将在GRS上展出。我们还计划 下午的GRC Power Hour，讨论女性在科学领域面临的挑战，并促进专业人士 女性的成长。本次会议的目标与国家法律文书研究所的使命密切相关。

SUMMARY Disorders of heart rhythm are the leading causes of sudden death and stroke. Progress in elucidating molecular, cellular and systems level mechanisms has promoted new concepts that have guided the development of more effective diagnostic and treatment strategies. However, cardiac arrhythmias remain major causes of morbidity and mortality throughout the world, and the need to push the boundaries of basic science discovery, which fuels translation, has never been more urgent. The 2019 Gordon Research Conference (GRC) on Cardiac Arrhythmia Mechanisms seeks to catalyze scientific advances to remedy this recalcitrant public health concern by assembling a cross-disciplinary program to inspire and drive the field by emphasizing multiscale challenges in understanding arrhythmia biology, highlighting emerging multidisciplinary investigational approaches, and featuring emerging therapeutic paradigms. This established biennial conference is widely regarded as the premier forum in which cutting edge concepts and new observations on mechanisms and treatment of cardiac rhythm disorders are presented. The Conference will bring together an international group of experts and trainees in many relevant fields, including genetics, basic electrophysiology, structural biology, biophysics, biomedical engineering, computer science, and clinical cardiology to interact in an informal atmosphere and share ideas about the mechanisms underlying normal and abnormal heart rhythms, including the causes of sudden cardiac death and stroke. The program includes current and emerging thought leaders in arrhythmia biology, investigators from complementary scientific disciplines, trainees and new investigators with promising careers. An objective of the Conference is to provide a forum for investigators – junior, mid-level and senior – to engage in focused discussion on the latest advances in the field of cardiac arrhythmia mechanisms, to bridge the gap between basic science and clinical applications, to stimulate new areas for collaboration, to promote collegiality and information sharing. The Conference will inspire and foster the career development of trainees by supporting an associated Gordon Research Seminar (GRS) at which trainees present their research findings and engage in panel discussions with mentors on matters of career pathways and professional development. A keynote address emphasizing the importance of scientific rigor and reproducibility in science will be featured at the GRS. We also plan an afternoon GRC Power Hour to discuss challenges women face in science and to promote the professional growth of women. The goals of this Conference are closely aligned with the mission of the NHLBI.