Skeletal muscle: development, regeneration and disease

亚历山德拉·萨科 摘要 骨骼肌：发展、再生和疾病会议的目标是带来 将骨骼肌研究的国际领先者聚集在一起，为尖端遗传学提供论坛， 肌肉发育、再生和疾病的细胞和分子生物学基础。这片边疆 由肌肉生物学学会组织的肌肉发生系列会议每三年举行一次 在过去的二十年里，它成功地定义了该领域的最先进水平。2019年会议将 不仅讨论骨骼肌发育和修复方面的最新发现，而且还将涵盖 我们对包括肌肉营养不良和癌症在内的人类疾病的了解取得了进展。我们的 主讲人将是Pura Muñoz-Cánoves博士，他在肌肉干细胞方面做出了非凡的工作 细胞老化和返老还童策略。计划举行10次全体会议，59位发言者(31位 特邀演讲者和从提交的摘要中选出的28人)高级、职业生涯中期和初级。 主题包括：骨骼肌发育，成肌细胞融合和核定位， 肌肉干细胞(MUSC)的静息、激活和表观遗传调控，新 从诱导多能干细胞获得骨髓间充质干细胞的方法，生物工程平台 骨骼肌模型，组织微环境在骨骼肌修复和疾病中的作用， 肌肉营养不良和癌症。被邀请的演讲者是因为他们在科学上的卓越表现而被选中的， 特别注意适当代表性(39%的妇女/少数群体)和地域多样性 (45%来自非美国国家)。演讲者被明确要求展示未发表的作品， 确保科学讨论集中在该领域的前沿。重要的是，我们第一次 与戈登肌肉发生研究会议(2019年6月，意大利)的组织者联系， 以避免两次会议上受邀发言的所有人重复发言。这种相互排斥的政策戏剧性地 增加了年轻科学家(26%的助理教授级别)被邀请发言的范围，使他们 这是在国际会议上发言的宝贵机会。我们还设计了程序 从摘要中挑选出28个简短的演讲，再次为后辈提供更多的机会 教师和博士后/学生出席。最后，我们将有三个海报会议，每个都伴随着 通过“海报闪电战”，选定的海报主持人将发表一分钟的演讲，以突出他们的作品， 提供宝贵的演示经验并促进网络交流。为了进一步促进互动，我们将 组织午餐会，分发演讲者，与会者可以报名加入他们的餐桌。 这次会议将提供一个论坛，讨论骨骼肌研究的最新发现，以及 促进不同研究领域的交叉受精，以进一步促进我们对肌肉的了解 生物学和对治疗学发展的帮助。

Sacco, Alessandra Summary The goal of the Skeletal muscle: development, regeneration and disease conference is to bring together international leaders in skeletal muscle research to provide a forum for cutting edge genetic, cellular and molecular biology underlying muscle development, regeneration and disease. This Frontiers in Myogenesis series organized by the Society for Muscle Biology has been held every three years for the last twenty years and has successfully defined the state of the art in the field. The 2019 meeting will not only discuss recent discoveries in skeletal muscle development and repair, but will also encompass advances in our understanding of human diseases, including muscular dystrophies and cancer. Our keynote speaker will be Dr. Pura Muñoz-Cánoves, who has performed exceptional work in muscle stem cell aging and rejuvenating strategies. Ten plenary sessions are planned, presenting 59 speakers (31 invited speakers and 28 selected from submitted abstracts) at the senior, mid-career and junior levels. Topics addressed will include: skeletal muscle development, myoblast fusion and nuclear positioning, regulation of muscle stem cell (MuSC) quiescence, activation, epigenetic control of MuSC, novel approaches for the derivation of MuSC from induced pluripotent stem cells, bioengineering platforms for skeletal muscle modeling, role of the tissue microenvironment in skeletal muscle repair and disease, muscular dystrophies, and cancer. Invited speakers have been selected for their scientific excellence, with particular attention to appropriate representation (39% women/minorities) and geographical diversity (45% are from non-US countries). Speakers are explicitly required to present unpublished work, to ensure scientific discussions focused at the forefront of the field. Importantly, and for the first time, we have liaised with the organizers of the Gordon Research Conference on Myogenesis (Italy, June 2019), to avoid all overlap in invited speakers at the two meetings. This mutual-exclusion policy has dramatically increased the range of young scientists (26% at Assistant Professor level) invited to speak, giving them the invaluable opportunity to present at an international conference. We have also designed the program to accommodate 28 short talks selected from abstracts, to again offer more opportunities for junior faculty and postdoc/students to present. Finally, we will have three poster sessions each accompanied by a “posters blitz” where selected poster presenters will give a one-minute talk to highlight their work, to provide invaluable experience in presenting and facilitate networking. To further foster interaction, we will organize lunch sessions where speakers are distributed and attendees can sign up to join their tables. This meeting will provide a forum for discussing recent discoveries in skeletal muscle research, and foster cross-fertilization from diverse areas of research, to further advance our understanding of muscle biology and help in development of therapeutics.