Simultaneous Hadamard Editing of GABA and Glutathione

项目摘要 编辑的磁共振波谱允许低浓度的非侵入性检测 脑内的代谢物，如抑制性神经递质GABA和氧化还原 复合谷胱甘肽（GSH）。这些代谢物的信号在MR中经常重叠 光谱，但定制的光谱编辑实验可以选择性地检索感兴趣的信号。 这种“编辑的”方法通常集中于测量单个代谢物（即GABA或GABA）。 GSH）在一个单一的大脑区域;这项建议的主要目标是发展阿达玛编辑 实验，同时检测GABA和GSH，在一个单一的收购。 我们将开发Hadamard编码的爱马仕方法和多体素Hadamard编辑， 使用SHERPA和HERMES-SHERPA方法。所得到的数据采集， 处理和分析工具将分发给临床 神经科学和神经影像学社区。

PROJECT SUMMARY Edited magnetic resonance spectroscopy allows the non-invasive detection of low-concentration metabolites within the brain, such as the inhibitory neurotransmitter GABA and the redox compound glutathione (GSH). The signals of such metabolites are often overlapped in the MR spectrum, but a tailored spectral editing experiment can selectively retrieve signals of interest. Such “edited” approaches generally focus on measuring a single metabolite (i.e. either GABA or GSH) in a single brain region; the main goal of this proposal is to develop Hadamard-edited experiments that detect GABA and GSH simultaneously, in a single acquisition. We will develop the Hadamard-encoded HERMES approach, and multi-voxel Hadamard editing, using the SHERPA and HERMES-SHERPA approaches. The resulting data acquisition, post- processing and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.