NNTC Data Coordinating Center

项目摘要/摘要 数据协调中心(DCC)支持国家神经艾滋病组织联盟(NNTC)。这个 该联盟由四个NNTC临床站点和DCC组成，它们作为资源共同工作 研究社区，向艾滋病毒/艾滋病调查人员提供经过临床注释的生前数据集 信息和相关的尸检组织和体液。DCC与NNTC临床中心合作 提供(1)管理和数据库功能的站点，以确保有效的临床和人脑银行 业务；(2)生物统计和艾滋病毒流行病学方面的科学专门知识，以支持对全国过渡委员会的广泛分析 支持队列招募和保留目标的临床数据库和分析；以及(3)确定 并为神经艾滋病研究人员提供解决方案。DCC是以下用户的联系人 资源(组织和/或数据请求)并为请求提供从提交到 满足请求并与请求者跟进，以提供他们的研究结果。DCC 扩大到包括宪章研究，引入纵向参与者和辅助研究。在接下来的这个 在供资期间，将开发全球CERCH，以实现合作和共享标本 和与脑脊液逃逸相关的数据，扩大了疾病预防控制中心支持正在进行的神经艾滋病研究的能力。这个 DCC网站被广泛用于传播资源信息(查询工具、报告、请求 应用程序)和管理任务，如资源跟踪、文档库和通信 活动。DCC提供了NNTC数据和标本的中央库存。与这份清单一起， 资源用户的生物信息学数据集等其他研究数据也是可用的。DCC 通过包括全面网站和会议在内的公关材料宣传NNTC 演示文稿。在过去的资助期间，NNTC支持了356项单独的研究资助和157项同行- 回顾了出版物。

Project Summary/Abstract The Data Coordinating Center (DCC) supports the National NeuroAIDS Tissue Consortium (NNTC). The consortium is composed of four NNTC Clinical Sites and the DCC that work cooperatively as a resource for the research community, providing HIV/AIDS investigators with clinically annotated datasets of antemortem information and associated postmortem tissue and fluids. The DCC works cooperatively with the NNTC Clinical Sites to provide (1) management and database capabilities to ensure effective clinical and brain banking operations; (2) scientific expertise in biostatistics and HIV epidemiology to support broad analyses of the NNTC clinical database and analyses that support the recruitment and retention goals for the cohort; and (3) identify gaps and provide solutions to neuroAIDS investigators. The DCC serves as the point of contact for users of the resource (tissue and/or data requests) and services the requests from the time they are submitted through fulfillment of the request and follow up with the requestor to provide the results of their research. The DCC expanded to include the CHARTER study bringing in longitudinal participants and ancillary studies. In this next funding period, the Global CERCH will be developed to enable collaborations and the sharing of specimens and data relating to CSF escape, expanding the DCC's ability to support ongoing neuroAIDS research. The DCC websites are used extensively for dissemination of resource information (query tools, reports, request applications) and management tasks such as resource tracking, document libraries, and communication activities. The DCC provides a central inventory of NNTC data and specimens. Along with this inventory, additional research data such as bioinformatics datasets by the users of the resource are available. The DCC promotes the NNTC through public relations materials including a comprehensive website and meeting presentations. In the past funding period, the NNTC supported 356 separate research grants and 157 peer- reviewed publications.