Southern HIV and Alcohol Research Consortium Administrative and Research Support Core

南方艾滋病毒酒精研究联盟（SHARC）成立于2012年，是五个国家之一。 艾滋病毒/艾滋病和酒精研究翻译联合会。SHARC的使命是改善健康 结果和减少艾滋病毒传播的人受酒精和艾滋病毒在佛罗里达。佛罗里达有 美国新感染艾滋病毒的比例最高，50岁以上的艾滋病毒+人群比例越来越高， 年龄、性别、种族/民族和地理（农村/城市）的人口多样性。 下一阶段 SHARC（2016-2021） 将重点关注酒精与艾滋病毒传播（包括艾滋病毒）的关系， 抑制）和HIV合并症（特别是脑功能和肝脏疾病）。 SHARC将由三个 综合提案将：集中我们的行政和研究基础设施（这U24），确定 酒精对大脑的有害方面是否可逆（U 01），并提供策略方面的专业知识， 改变饮酒行为和生物统计学分析（U24）。具体而言，U24提案将 集中SHARC管理服务，并继续代表 行政 佛罗里达队列研究 SHARC基础设施和协作活动的骨干。该队列将成为以下研究的受试者来源： 我们的U 01研究，以及队列和U 01项目都将得到U24行为/生物统计的支持。 核心U24的具体目标是目标1：E 确保所有人的领导、协作和科学监督 与SHARC有关的活动。具体而言，核心将： 从执行委员会、科学委员会、 咨询委员会和社区咨询委员会;监督我们的科学贡献和研究 生产力， 管理日常运营，协调和促进访问SHARC数据的请求，和/或 生物样本，提供IRB和监管支持，并传达我们的科学发现。目标二： 支持正在进行的与佛罗里达队列相关的合作研究活动。该队列于2014年启动 并将完成1700人的入组（1500名HIV+，200名HIV-）。其中，900名艾滋病毒阳性者将被追踪 前瞻性地使用酒精消费、神经认知、肝病和HIV病毒的增强措施， 镇压这900人将包括300名重度饮酒者（女性每周饮酒超过7杯，男性每周饮酒超过14杯）， 300人适度饮酒，300人目前没有饮酒。 佛罗里达队列代表了 SHARC基础设施使我们能够a） 参与合作研究，将公共卫生环境与 学术机构; B）支持和扩大我们的培训和发展计划;以及c）促进 招募参与者进入我们的同伴U 01通过一个 参与者联系登记处 .广泛的饮酒范围 群体内的行为和群体多样性将允许 我们来比较大量饮酒对 不同人群和社区的艾滋病毒成果。 通过与至少8个不同的公共卫生部门合作， 诊所和整个国家的设置，我们现在准备合作的一系列干预和 针对个人和公共卫生诊所和环境的实施研究。

The Southern HIV Alcohol Research Consortium (SHARC) was established in 2012 as one of five national Consortia for HIV/AIDS and Alcohol Research Translation. The mission of SHARC is to improve health outcomes and reduce HIV transmission in persons affected by alcohol and HIV in Florida. Florida has the highest rate of new HIV infections in the US, a growing proportion of HIV+ persons over age 50, and broad population diversity across age, gender, race/ethnicity, and geography (rural/urban). The next phase of SHARC (2016-2021) will focus on the relationship of alcohol to HIV transmission (including HIV viral suppression) and HIV comorbidities (especially brain function and liver disease). SHARC will consist of three integrated proposals that will: centralize our administrative and research infrastructure (this U24), determine whether harmful aspects of alcohol on the brain are reversible (U01), and provide expertise in strategies to change drinking behavior and in biostatistical analyses (U24). Specifically, this U24 proposal will centralize SHARC administrative services, and also continue represents the Administrative the Florida Cohort study that backbone of SHARC infrastructure and collaborative activity. The Cohort will be the source of participants for our U01 research, and both the Cohort and U01 projects will be supported by the U24 behavioral/biostatistical core. The specific aims of this U24 are Aim 1: E nsure leadership, collaboration, and scientific oversight for all activities related to SHARC. Specifically, the Core will: obtain input from an Executive Committee, a Scientific Advisory Board, and a Community Advisory Board; monitor our scientific contributions and research productivity, manage day-to-day operations, coordinate and facilitate requests to access SHARC data and/or biological samples, provide IRB and regulatory support, and communicate our scientific findings. Aim 2: Support ongoing collaborative research activity related to the Florida Cohort. The Cohort was initiated in 2014 and will complete enrollment of 1700 persons (1500 HIV+, 200 HIV-). Of these, 900 HIV+ will be tracked prospectively using enhanced measures of alcohol consumption, neurocognition, liver disease, and HIV viral suppression. These 900 will include 300 with heavy drinking (> 7 drinks/week women, >14 drinks/week men), 300 with moderate drinking, and 300 with no current drinking. The Florida Cohort represents the backbone of SHARC infrastructure that allows us to a) engage in collaborative research that links public health settings and academic institutions; b) support and expand our Training and Development Program; and c) facilitate recruitment of participants into our companion U01 via a participant contact registry . The wide range of drinking behavior and population diversity within the Cohort will allow us to compare the impact of heavy drinking on HIV outcomes across diverse populations and communities. By partnering with at least 8 distinct public health clinics and settings across the state, we are now poised to collaborate on a range of intervention and implementation studies targeting individuals and public health clinics and settings.