Universal Edited MRS at 3T

项目摘要 许多生物化学上有趣的分子，包括抑制性和兴奋性神经递质 GABA和天冬氨酸，氧化还原化合物谷胱甘肽和抗坏血酸，以及神经调节剂N- 乙酰基谷氨酸可以使用编辑的1H磁共振成像在人脑中非侵入性地测量。 共振波谱（MRS）。直到最近，编辑的MRS一直被用作单代谢物 单体素方法-即需要10分钟的采集来测量GABA，以及额外的 实验来测量其他代谢物。这大大限制了应用的广度。 在临床研究中编辑MRS，特别是例如不同的MRS之间的相互作用的研究， 系统.这项赠款的总体目标是开发一种通用的采集和处理系统， 用于测量人类大脑中所有这些可编辑代谢物的水平的管道， 实验 我们将开发一个单一的序列，在所有三个主要供应商的平台上实现， 编辑3 T，Gannet Toolkit进行定量数据分析，并演示跨平台 新测量的等效性。由此产生的数据采集和分析工具将由 可用于传播到临床神经科学和神经影像学社区。

PROJECT SUMMARY Many biochemically interesting molecules, including the inhibitory and excitatory neurotransmitters GABA and aspartate, the redox compounds glutathione and ascorbate, and the neuromodulator N- acetylaspartylglutamate can be measured in the human brain non-invasively using edited 1H magnetic resonance spectroscopy (MRS). Until very recently, edited MRS has been applied as a single-metbaolite single-voxel method – i.e. requiring a 10-minute acquisition to measure GABA, and additional experiments to measure other metabolites. This has substantially limited the breadth of application of edited MRS in clinical studies, and particularly studies of, for example, interactions between different systems. The overall goal of this grant is the development of a universal acquisition and processing pipeline for measuring levels of all these editable metabolites in the human brain from a single experiment. We will develop a single sequence, implemented on all three major vendor platforms, for multiplexed editing 3T, the Gannet Toolkit for quantitative data analysis, and demonstrate the cross-platform equivalence of the new measurement. The resulting data acquisition and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.