Postdoctoral Training in Reproductive Mood Disorders

项目摘要 拟议的培训计划的目的是“生殖情绪障碍博士后培训”， 培养在生物学基础和临床相关（预测）表型方面具有专业知识的研究人员， 生殖情绪障碍（围产期抑郁症、经前焦虑症和围月经期抑郁症） 抑郁症）。这是一个为期两年的MD，PhD和MD/PhD学员培训计划。培训将涉及一个 基础广泛和综合的观点，不仅涉及精神病学，而且涉及遗传学，内分泌学， 神经科学和妇产科。 该计划强调培养生殖情绪的病理生理机制 疾病，学员将掌握以下内容：生殖激素生理学和信号; 操纵生殖系统的方法和生殖情绪的临床现象学 紊乱此外，学员将在三种方法培训轨道中的至少一种方面发展专业知识： 神经科学、遗传学或压力生理学。研究员将有一个主要的研究导师（代表 他们的培训轨道）和二级导师（从不同的轨道），从而提供额外的接触， 科学的跨学科性和协作性。除了体验机会， 计划教师，教学法将量身定制的个人研究员，以确保每个实现能力， 他们选择的研究路线。培训的一个关键要素还包括一个独立的研究项目。 因此，虽然培训计划是多学科的，但重点放在个性化培训上 对研究员的经验。然而，通过一些计划的具体场地设计，使 研究员一起交流思想和支持，该计划将确保之间的凝聚力， 实习生完成该计划的研究员将准备成为独立的研究人员， 研究生殖情绪障碍的生物行为机制的独特必要基础， 在未来的独立研究中识别治疗性生物靶点的能力。 位于查佩尔山的北卡罗来纳州大学是该项目的理想选择，因为它 拥有一个著名的合作基础设施，一个充满活力的妇女情绪障碍临床计划（其中 包括该国第一个也是唯一的围产期抑郁症住院计划），以及 研究人员在生殖情绪障碍与成功的跟踪记录。

PROJECT SUMMARY The purpose of the proposed training program, “Postdoctoral Training in Reproductive Mood Disorders” is to develop researchers with expertise in both the biological basis and clinically relevant (predictive) phenotypes of reproductive mood disorders (perinatal depression, premenstrual dysphoric disorder, and perimenopausal depression). This is a two year training program for MD, PhD and MD/PhD trainees. Training will involve a broad-based and integrative perspective, involving not only psychiatry but genetics, endocrinology, neuroscience, and obstetrics/gynecology. With this program’s emphasis on training in pathophysiological mechanisms that underlie reproductive mood disorders, trainees will develop mastery in the following: reproductive hormonal physiology and signaling; methods for manipulating the reproductive system; and clinical phenomenology of reproductive mood disorders. Additionally, trainees will develop expertise in at least one of thre methodological training tracks: Neurosciences, Genetics, or Stress Physiology. Fellows will have a primary research mentor (representing their training track) and a secondary mentor (from a different track), thereby providing additional exposure to both the interdisciplinarity and collaborative nature of science. In addition to experiential opportunities with program faculty, didactics will be tailored to the individual fellow to ensure that each achieves competence in their chosen research track. A key element of the training as well includes an independent research project. Thus, while the training plan is multidisciplinary, an emphasis is placed on individualizing the training experience for the Fellows. However, through a number of program specific venues designed to bring the Fellows together for exchange of ideas and support, the program will ensure cohesiveness among the trainees. Fellows who complete this program will be poised to become independent researchers, having the unique requisite foundation to examine biobehavioral mechanisms in reproductive mood disorders and the ability to identify therapeutic biologic targets in their future independent research. The University of North Carolina at Chapel Hill represents an ideal setting for the proposed program because it possesses a well-known collaborative infrastructure, a vibrant women’s mood disorder clinical program (which includes the first and only inpatient perinatal depression program in the country), and a critical mass of researchers in reproductive mood disorders with a track record of success.