Bioinformatics (BISR)

项目摘要/摘要：生物信息学共享资源(BISR) 生物信息学已经成为癌症研究不可或缺的一部分，因为它具有高通量的性质 癌症研究项目产生的实验数据(广泛称为“组学”数据)。 因此，对于开发用于收集、处理、 存储、分析和促进癌症研究界对此类数据的使用。的主要目标 生物信息学核心是促进生物信息学资源和当前技术的获取，并 在使用计算资源和数据分析工具方面提供支持和培训研究人员 生物信息学。拟议的生物信息学核心配备了当地安装的生物信息学工具和 数据库、经许可的软件工具(向量NTI、独创性路径分析、iPathway、CLC基因组学 工作台和Lasergene)、专用计算服务器、带备份选项的数据存储以及访问 到高端计算服务器。核心提供范围广泛的生物信息服务，分为五个方面 专题领域包括(一)分析基于下一代测序的基因组学数据；(二)分析 基于阵列的和系统生物学数据的使用；(3)使用计算机编程、机器学习和高- 研究项目中的绩效计算；(4)开发软件和数据库应用程序 生物信息学项目；以及(V)科学咨询。在过去的4年里，核心支持 内布拉斯加大学医学中心(UNMC)的多个研究项目，超过一半的核心 来自巴菲特癌症中心的用户。癌症中心使用的大多数核心服务 研究人员从事基于NGS的分析和与系统生物学相关的分析。核心主任由四人协助 训练有素的支持人员，在计算机科学、统计学、癌症基因组学方面有不同的培训背景 和系统生物学。由代表不同学院和学校的成员组成的顾问委员会 在UNMC负责监督核心。委员会检讨现有服务，并建议新服务、检讨 经营政策和服务收费。核心人员得到了机构、巨蟹座的支持 中心和其他校外赠款，为核心提供稳定和可持续的环境，因此 促进招聘、培训和留住核心领域的有能力和多样化的专业人员，特别是 对癌症中心很重要。此外，核心主任还领导了一个癌症基因组学研究小组 和生物信息学，并与许多癌症中心的调查人员合作。这些合作 促进开发适合癌症中心需求的新的定制数据分析协议 研究项目和创造协同作用的机会，以发展癌症跨学科研究计划 生物学。

Project Summary/Abstract: Bioinformatics Shared Resource (BISR) Bioinformatics has become an integral part of cancer research due to the high-throughput nature of experimental data (broadly dubbed as `omics' data) that are being generated from cancer research projects. Thus, a tremendous need exists for developing computational infrastructure for the collection, processing, storage, analysis, and facilitation of the use of such data by the cancer research community. The main goals of the Bioinformatics Core are to facilitate access to bioinformatics resources and current technology, and to provide support and train researchers in the use of computational resources and data analysis tools in bioinformatics. The proposed Bioinformatics Core is equipped with locally installed bioinformatics tools and databases, licensed software tools (Vector NTI, Ingenuity Pathway Analysis, iPathway, CLC Genomics workbench, and Lasergene), dedicated computational servers, data storage with backup options, and access to high-end computing servers. The Core offers a wide range of bioinformatic services that fall into five thematic areas including (i) analysis of next-generation sequencing (NGS)-based genomics data; (ii) analysis of array-based and systems biology data; (iii) use of computer programming, machine-learning, and high- performance computing in research projects; (iv) development of software and database applications for bioinformatics projects; and (v) scientific consultation. Over the past 4 years, the Core has supported numerous research projects at the University of Nebraska Medical Center (UNMC) with over half of the Core users hailing from the Buffett Cancer Center. Majority of the Core services used by the Cancer Center investigators fall into NGS-based and systems biology related analyses. The Core Director is assisted by four well-trained support staff with diverse training backgrounds in computer science, statistics, cancer genomics and systems biology. An advisory board that consists of members representing different colleges and schools at UNMC oversees the Core. The board reviews the existing services and suggests new services, reviews the operating policies and service charges. The Core personnel have been supported by institutional, cancer center and other extra-mural grants, which confer stable and sustainable environment to the Core, thus facilitates the hiring, training and retaining competent and diverse expertize in the Core that is particularly important to the Cancer Center. In addition, the Core Director also leads a research group in cancer genomics and bioinformatics and collaborates with a number of cancer center investigators. These collaborations facilitate the development of novel and customized data analysis protocols that suit the needs of cancer center research projects and create synergistic opportunities to develop interdisciplinary research programs in cancer biology.