General Motor Control Mechanisms and Disease Training Program

项目摘要/摘要 有效地启动、执行和终止运动的能力对生存至关重要，但在 一系列衰弱的疾病。准确地说，神经系统是如何编码运动的，以及这种神经是如何 机器因疾病而受损，人们对此知之甚少。神经科学的主要使命 社区就是要填补我们知识中的这些空白，并将这些新信息转化为更好的临床 练习一下。为了将这一跨越几代人的努力发扬光大，关键是早期职业科学家-- 训练有素。他们需要牢牢掌握我们知道和不知道的东西，分子方面的实验技能， 细胞和系统水平，并致力于严谨、定量和伦理研究。带着这些目标 考虑到，一个由30名世界领先的基础、临床和翻译运动控制科学家组成的小组已经来到 在D.James Surmeier博士的指导下，共同为以下人员提供培训计划 西北大学的博士生致力于运动控制研究。世界银行的目标是 NU通用运动控制机制和疾病培训计划(GMCMD-TP)是：1)教育 分子、细胞和临床运动系统神经科学基础、翻译和临床培训学员 系统级别；2)向受训人员提供必要的概念、技术和量化技能，以 解决重大问题，挑战教条，做出有影响力的研究发现；3)鼓励 培训学员考虑他们研究的疾病相关性及其翻译潜力；4)灌输 学员致力于严谨、道德和负责任的研究；5)提高学员在 交流他们的研究；6)给实习生机会推进他们的职业目标，以便我们 支持电机控制领域的下一代领军人物。南洋理工大学博士后实习生 跨部门神经科学(NUIN)计划与生物医学的神经工程轨道 工程计划，以及计划教员实验室的博士后实习生有资格参加 GMCMD-TP。GMCMD-TP包括：1)涵盖电机系统各个方面的核心课程， 题为《运动的神经控制》；2)每月由教官举办关于运动控制的研讨会 研究计划；3)统计方面的培训和咨询；4)年度静修，所有成员 NU运动控制研究界齐聚一堂，交流和讨论他们的研究；5)a) 基础科学家和临床医生的运动障碍杂志俱乐部；6)跟踪机会 运动障碍临床医生；7)几个年度研究中心日，每个研究中心都专注于一种特定的运动 控制疾病。此外，GMCMD-TP学员利用个人发展计划和NU专业人员 进一步促进职业发展的发展计划。每年最多4名博士后和3名博士后 博士生将有资格获得1-2年的直接支持。GMCMD-TP实验室的实习生没有 接受直接支持的人都提供同样的培训。

PROJECT SUMMARY/ABSTRACT The ability to initiate, execute, and terminate movement effectively is critical for survival but is impaired in a range of debilitating diseases. Precisely how the nervous system encodes movement and how this neural machinery is compromised by disease remain poorly understood. A primary mission of the neuroscience community is to fill these gaps in our knowledge and translate this new information into better clinical practice. To carry this multi-generational effort forward, it is critical that early career scientists are well- trained. They need a firm grasp of what we know and don't know, experimental skills at the molecular, cellular, and systems levels, and dedication to rigorous, quantitative, and ethical research. With these goals in mind, a group of 30 world-leading basic, clinical and translational motor control scientists have come together under the directorship of Dr. D. James Surmeier to deliver a training program for pre- and post- doctoral scientists committed to motor control research at Northwestern University (NU). The goals of the NU General Motor Control Mechanisms and Disease Training Program (GMCMD-TP) are: 1) to educate trainees in basic, translational, and clinical motor systems neuroscience at the molecular, cellular, and systems levels; 2) to provide trainees with the conceptual, technical, and quantitative skillsets necessary to address major questions, challenge dogma and make impactful research discoveries; 3) to encourage trainees to consider the disease relevance of their research and its translational potential; 4) to instill in trainees a deep commitment to rigorous, ethical, and responsible research; 5) to enhance trainees' skills in communicating their research; 6) to give trainees opportunities to advance their career goals so that we support the next generation of leaders in the field of motor control. Pre-doctoral trainees in the NU Interdepartmental Neuroscience (NUIN) program and the Neural Engineering track of the Biomedical Engineering program, and post-doctoral trainees in the laboratories of program faculty are eligible for the GMCMD-TP. The GMCMD-TP consists of: 1) a core course covering each aspect of the motor system, entitled “The Neural Control of Movement”; 2) monthly seminars by preceptors on their motor control research programs; 3) training and consultation in statistics; 4) an annual retreat where all members of the NU motor control research community come together to communicate and discuss their research; 5) a movement disorders journal club for basic scientists and clinicians; 6) opportunities for shadowing movement disorder clinicians; 7) several annual research center days, each focused on a specific motor control disease. In addition, GMCMD-TP trainees utilize Individual Development Plans and NU professional development programs to further promote career advancement. Each year up to 4 pre-doctoral and 3 post- doctoral trainees will be eligible for direct support for 1-2 years. Trainees in GMCMD-TP labs who do not receive direct support are offered the same training.