Research Training Program in Environmental Pediatrics

项目总结 儿童暴露在多种环境危害中--有毒化学物质、社会应激源和 建筑环境。研究表明，早期暴露于环境中会导致 儿童疾病(哮喘、学习障碍、出生缺陷、肥胖)和成人生活中的疾病。然而，几乎没有人 儿科医生接受的培训是诊断、治疗或预防环境引起的疾病，但很少有学者 健康中心有环境儿科的研究项目。国际移民组织表示，有一个国家 需要扩大环境医学的科学队伍，以及NIH的新倡议(CHEAR和 Echo)强调，儿童的环境健康是研究的优先事项。因此，显然有必要 为受过环境儿科学原理和方法培训的科学家。为了满足这一需求， 西奈山医学院寻求更新其3年制跨学科、住院医师/博士后 2007年开始的环境儿科研究培训计划。每年接纳两名新研究员 年。遴选竞争非常激烈，研究员是受过临床训练的儿科医生和医生的混合体。 训练有素的研究科学家。在第一年，重点是流行病学、生物统计学、毒理学、 和环境医学，公共卫生硕士学位被授予流行病学专业。在第二年和第三年， 重点更多地转向指导性研究，即出版出版物、会议演示文稿/海报、 并促进向独立研究的过渡，重点是K奖的申请。我们提供 在环境健康原则方面有坚实的方法学基础和多才多艺的技能和 他们可以用来研究广泛的科学问题的资源。每个研究员都由一位 临床和基础科学家的指导团队。课程和体验式培训以助学金写作形式提供。 以及负责任的研究行为。提供环境儿科的临床指导经验，以 确保研究培训以临床翻译原则为基础。对每个研究员的正式评估是 每半年进行一次。一个执行学院委员会和一个外部咨询委员会已经在 地点。预期结果包括1-2个研究手稿的作者，2-3个海报的作者或 国家会议上的平台，在第二年制定的K赠款提案，以及过渡到 独立调查员身份。该计划建立在儿童环境健康的独特基础上 研究，包括儿童健康暴露评估资源(CHEAR)实验室中心，CHEAR数据 中心，NIH P30核心中心，近12个儿童健康研究队列，儿科环境 健康专科单位，以及专门研究暴露生物标记物的独特的Exposome实验室。在过去的9年中 几年来，我们的项目已经成功招募了19名研究员，并毕业了12名(其中6名是现役人员)。五个人已经获得了 国家卫生研究院的资助。毕业生目前在加州大学戴维斯分校、纽约大学、辛辛那提大学、西奈山大学以及工作 在疾控中心和工业界。我们的毕业生在9年内发表了70多篇论文。

PROJECT SUMMARY Children are exposed to multiple environmental hazards—toxic chemicals, social stressors, and the hazards of the built environment. Research indicates that early-life environmental exposures contribute to common pediatric diseases (asthma, learning disorders, birth defects, obesity) and to diseases in adult life. Yet few pediatricians are trained to diagnose, treat, or prevent diseases of environmental origin, and few academic health centers have research programs in environmental pediatrics. The IOM states that there is a national need to expand the scientific workforce in environmental medicine, and new NIH initiatives (CHEAR and ECHO) have emphasized that children's environmental health is a research priority. Thus, there is a clear need for scientists trained in the principles and methodologies of environmental pediatrics. To address that need, the Mount Sinai School of Medicine seeks renewal of its 3-year, interdisciplinary, post-residency/post-doctoral research training program in environmental pediatrics that began in 2007. Two new fellows are admitted per year. Selection is highly competitive, and fellows are a mix of clinically trained pediatricians and doctorally trained research scientists. In year 1, focus is on education training in epidemiology, biostatistics, toxicology, and environmental medicine, and an MPH degree is granted concentrating in epidemiology. In years 2 and 3, emphasis shifts more toward mentored research that produces publications, meeting presentations/posters, and fosters transition toward independent research with an emphasis on K award applications. We provide fellows with a strong methodological base in environmental health principles and a versatile set of skills and resources that they can apply to study a wide range of scientific questions. Each fellow is guided by a mentoring team of clinical and basic scientists. Courses and experiential training are provided in grant writing and responsible conduct of research. Supervised clinical experience in environmental pediatrics is offered to ensure that research training is grounded in clinical translational principles. Formal evaluation of each fellow is conducted semi-annually. An Executive Faculty Committee and an External Advisory Board are already in place. Expected outcomes include authorship of 1-2 research manuscripts, authorship of 2-3 posters or platforms at national meetings, development in year 2 of a K grant proposal, and evidence of transition toward independent investigator status. This program builds on a unique base of children's environmental health research, including a Child Health Exposure Assessment Resource (CHEAR) Lab Hub, the CHEAR Data Center, an NIH P30 Core Center, nearly a dozen child health research cohorts, a Pediatric Environmental Health Specialty Unit, and a unique Exposome Lab that specializes in exposure biomarkers. In the past 9 years, our program has successfully recruited 19 fellows and graduated 12 (6 are active). Five have secured NIH funding. Graduates are currently faculty UC-Davis, NYU, U of Cincinnati, Mount Sinai, as well as working at CDC and for Industry. Our graduates have published over 70 papers in 9 years.