Administrative Core

项目摘要：行政核心 C-SIG行政核心的目标是为中心的总体方向提供领导 并优化会员从中心计划和核心中获得的利益。C-Sig行政核心领导层是 由主任N.F.LaRusso博士、联席主任G.J.Gores博士和副主任V.H.Shah博士提供 与执行委员会、内部咨询委员会和外部咨询委员会联手 委员会审议阶段。执行委员会由CORE的主任、联席主任、副主任组成 机制研究主题小组(细胞内信号传递、细胞间信号传递)的负责人 传播学和遗传学/表观遗传学)，以及胃肠病学和表观遗传学分部的主要领导人 肝病，每月开会一次。内部咨询委员会每季度召开一次会议，定期提供 就中心的战略方向向执行委员会提供意见，并促进沟通 由机构领导人组成的外部咨询委员会由五名国际知名人士组成 消化系统疾病研究的带头人，每年面对面和开会 根据需要召开会议，定期向执行委员会提供反馈。管理员提供 为中心的实时财务管理和运营提供必要的支持。一个新招募的核心 项目经理执行日常核心项目管理，以提高核心流程的标准化； 简化工作流程的效率，提高交付质量。行动委员会由以下成员组成 主任、联席主任、行政长官和核心项目经理每周开会，规划和管理C- 签名操作。行政领导确保C-SIG核心对 并对核心职能进行监督。C-SIG的目标是通过以下方式促进细胞信号科学： I)通过扩大已建立的全球倡议的技术和协作能力，促进多学科研究 科学家和吸引其他学科的研究人员；二)确定和培养新的胃肠病研究人员 通过同行评审的试点和可行性(P/F)计划，包括职业发展研讨会、课程、 和结构化指导(19/26，73%的P/F接受者获得联邦资助)；iii)提供以核心为基础的 专门的设备、技术、方法、试剂和专业知识(光学显微镜、临床、 以及基因编辑和表观基因组学核心)，具有持续的核心菜单更新、质量保证和 根据成员的反馈进行评估和项目管理监督；四)支持健全的 浓缩计划；以及v)促进C-Sig与梅奥其他NIDDK中心之间的互动 (例如，PKD中心)和现有的复员方案协调中心，特别是在中西部(即中西部复员方案协调中心联盟)。

PROJECT SUMMARY: ADMINISTRATIVE CORE The objective of the C-SiG Administrative Core is to provide leadership for the overall direction of the Center and to optimize member benefits from Center Programs and Cores. C-SiG Administrative Core leadership is provided by Dr. N.F. LaRusso, Director, Dr. G.J. Gores, Co-Director, and Dr. V.H. Shah, Associate Director, in conjunction with an Executive Committee, an Internal Advisory Committee, and an External Advisory Committee. The Executive Committee is comprised of the Director, Co-Director, Associate Directors, Core Directors, the Leaders of the Mechanistic Research Theme groups (Intracellular Signaling, Cell-to-Cell Communication, and Genetics/Epigenetics), and key leaders within the Division of Gastroenterology and Hepatology, and meets monthly. The Internal Advisory Committee meets quarterly and provides regular input to the Executive Committee regarding the strategic direction of the Center and facilitates communication with institutional leaders The External Advisory Committee consists of five internationally prominent investigators who are leaders in digestive disease research and meets annually in person and by conference call as needed to provide regular feedback to the Executive Committee. An Administrator provides the necessary support for real-time financial management and operations of the Center. A newly recruited Core Project Manager performs day-to-day Core project management to improve standardization of core processes, streamline efficiency of workflows, and enhance deliverable quality. The Operations Committee consists of the Director, Co-director, Administrator and Core Project Manager and meets weekly to plan and manage C- SiG operations. The administrative leadership assures responsiveness of the C-SiG Cores to the needs of the members and provides oversight for Core functions. C-SiG's goals are to promote cell signaling science by: i) Fostering multidisciplinary research by expanding technical and collaborative capabilities of established GI scientists and attracting investigators from other disciplines; ii) Identifying and nurturing new GI investigators via a peer-reviewed Pilot and Feasibility (P/F) Program including career development workshops, curricula, and structured mentorship (19/26, 73% of P/F recipients achieving federal funding); iii) Offering core-based specialized equipment, technologies, methodologies, reagents, and expertise (Optical Microscopy, Clinical, and Gene Editing and Epigenomics Cores), with continuous core menu updates, quality assurance and assessments, and project management oversight in response to member feedback; iv) Supporting a robust Enrichment Program; and v) Promoting interactions between C-SiG with other NIDDK centers at Mayo (e.g., PKD Center) and existing DDRCCs, especially in the Midwest (i.e., Midwest DDRCC Alliance).