Palliative Care Research Cooperative Group (PCRC): Refinement and Expansion

项目总结/摘要 生命终结和姑息治疗（EOLPC）旨在提高那些患有严重疾病的人的生活质量， 照顾者EOLPC的需求和交付远远超过了提供证据的研究， 最佳实践小型、单中心试验、不具代表性的研究队列和缺乏足够严格性的研究 提供高质量的EOLPC。虽然其他领域已经通过大规模的， 尽管EOLPC的研究具有多样性和多地点试验的特点，但由于基础设施和科学研究不足， 劳动力此U2 C应用程序的主要目标是提高生产力和影响力， 姑息治疗研究合作组（PCRC），其能力，以促进高质量的， 有效的临床研究，并扩大姑息治疗研究人员的数量和专业知识， 多中心临床试验。PCRC致力于通过为调查人员提供 开展大规模、多中心临床试验和其他研究所需的广泛支持。 这种支持包括培训机会、试点赠款、访问大型集中数据库 从EOLPC研究，方法学咨询，研究活动的行政协调，和访问 潜在研究入组中心的大型网络。在结构上，该中心由六个协同作用的部门组成， 每个组件由一名高级EOLPC研究员领导。项目协调中心统筹协调 PCRC的管理。研究者发展中心建立EOLPC研究人员的技能。 四个核心提供方法学专业知识：数据，信息学和统计学;测量;护理人员 研究;和临床研究/方法。U2 C PCRC应用解决了科学、运营、 能力建设和合作目标。通过实现这些目标，该中心将扩大其能力， 支持强大的跨学科EOLPC研究人员社区，他们解决指导交付的主题 姑息治疗的最终目标是改善重病患者及其家人的生活 照顾者

PROJECT SUMMARY/ABSTRACT End of life and palliative care (EOLPC) seeks to enhance quality of life for those with serious illness and their caregivers. The need for and delivery of EOLPC have far exceeded the research that provides evidence of best practices. Small, single-site trials, unrepresentative study cohorts, and studies lacking sufficient rigor hamper provision of high-quality EOLPC. While other fields have advanced their evidence through large, diverse, multi-site trials, EOLPC research has been impeded by an insufficient infrastructure and scientific workforce. The primary goals of this U2C application are to increase the productivity and impact of the Palliative Care Research Cooperative Group (PCRC), its ability to facilitate the conduct of high-quality, effective clinical research, and to expand the number and expertise of palliative care researchers in conducting multi-site clinical trials. The PCRC strives to advance the science of EOLPC by providing investigators with the broad range of support necessary to conduct large scale, multi-site clinical trials and other research studies. This support includes training opportunities, pilot grant awards, access to a large, centralized repository of data from EOLPC studies, methodologic consultation, administrative coordination of research activities, and access to a large network of potential study enrollment sites. Structurally, the PCRC consists of six synergistic components, each led by a senior EOLPC researcher. The Project Coordinating Center coordinates overall administration of the PCRC. The Investigator Development Center builds the skills of EOLPC researchers. Four Cores provide methodological expertise: Data, Informatics, and Statistics; Measurement; Caregiver Research; and Clinical Studies/Methodology. The U2C PCRC application addresses Scientific, Operational, Capacity-building, and Collaborative Aims. By accomplishing these aims, the PCRC will expand its ability to support a robust community of interdisciplinary EOLPC researchers who address topics that guide the delivery of palliative care with an ultimate goal of improving the lives of patients with serious illness and their caregivers.