1/3 Alcohol Research Consortium in HIV - Administrative Core (ARCH-AC)

这项针对艾滋病毒酒精研究联盟(ARCH)的竞争性续签申请建立在 在我们最初的NIAAA资助期间，扩展了我们非常成功的管理和研究成果 句号。ARCH被整合到一个成熟的、具有科学生产力的全国艾滋病毒临床队列中， CFAR综合临床系统网络(CNICs)，由8个临床队列和30,000多人组成的网络 美国各地的艾滋病毒携带者(PLWH)。这一动态队列提供了一个理想的科学平台 通过收集全面的临床数据和标本进行艾滋病毒和酒精的长期研究 以及统一收集的患者报告的结果。ARCH财团由行政部门组成 核心(ARCH-AC)、流行病学研究部分(ARCH-ERA)和干预研究 组件(ARCH-IRA)。此外，我们在每项研究中都嵌入了一个新的资源核心 组件，以充分利用我们的专业知识，并扩大我们在两个新的关键领域的能力 与艾滋病毒和酒精服务和研究的相关性：生物统计核心(位于流行病学补助金中 ARCH-ERA)和电子健康技术核心(位于ARCH-IRA干预补助金中)。最重要的是 我们联盟的目标是改善临床结果，减少酗酒者之间的健康差距。 通过开发和测试实时通知的定制干预(ARCH-IRA)来滥用 数据收集和分析(ARCH-ERA)。我们联盟解决的具体主题包括健康 差异、精确医学、实施科学、最先进的生物统计学方法，以及 电子健康技术。ARCH管理核心(AC)是本应用程序的重点，它提供 监督、协调和指导联合体的基础设施，并促进科学 ARCH的流行病学目标和干预措施。结构包括：一名高管 包括科学顾问委员会在内的研究指导委员会；关键科学工作 小组来概念化和实施学习目标。ARCH-AC由酒精使用方面的国家专家共同领导 疾病和艾滋病毒，他们在流行病学和艾滋病方面有30多年的综合科学经验 艾滋病毒/艾滋病的临床研究。AC提供关键基础设施以：1)促进通信， ARCH组件和研究人员、NIAAA合作者、Science 咨询委员会、CHAART和其他酒精/艾滋病毒联合会；2)监督ARCH科学 流行病学和干预目标；3)优化研究之间ARCH资源的协调 项目和外部团体，特别是数据储存库、流行病学/生物统计支助和 调查专门知识；4)促进初级调查人员的科学参与 酒精和/或艾滋病毒；5)支持ARCH调查人员通过陈述传播信息， 出版物、网站维护和其他公共传播战略。

This competitive renewal application for the Alcohol Research Consortium on HIV (ARCH) builds on and extends our very successful administrative and research accomplishments during our initial NIAAA funding period. ARCH is integrated into a well-established, scientifically productive, national HIV clinical cohort, the CFAR Network of Integrated Clinical systems (CNICS), a network of 8 clinical cohorts and over 30,000 persons living with HIV (PLWH) across the United States. This dynamic cohort provides an ideal scientific platform for long-term study of HIV and alcohol through the collection of comprehensive clinical data and specimens as well as uniformly-collected patient reported outcomes. The ARCH consortium consists of the Administrative Core (ARCH-AC), the epidemiological research component (ARCH-ERA), and an intervention research component (ARCH- IRA). In addition, we have embedded a nascent resource core into each of the research components to capitalize on our expertise and expand our capacity in two new and critical areas of high relevance to HIV and alcohol services and research: the Biostatistics Core (housed in the epidemiology grant ARCH-ERA) and an eHealth Technology Core (housed in the intervention grant ARCH-IRA). The overarching goal of our consortium is to improve clinical outcomes and reduce health disparities among PLWH with alcohol misuse through development and testing of tailored interventions (ARCH-IRA) that are informed by real-time data collection and analysis (ARCH-ERA). Specific themes addressed by our consortium include health disparities, precision medicine, implementation science, state-of-the-art biostatistical methodology, and eHealth technology. The ARCH Administrative Core (AC), the focus of this application, is the U24 that provides the infrastructure for oversight, coordination and direction to the consortium, and facilitates the scientific goals of the epidemiology and intervention components of ARCH. The structure includes: an executive committee; a research steering committee which includes a scientific advisory board; key scientific working groups to conceptualize and implement study aims. ARCH-AC is co-led by national experts in alcohol use disorders and HIV, who have over 30 years of combined scientific experience in conducting epidemiologic and clinical research in HIV/AIDS. The AC provides the critical infrastructure to: 1)Facilitate communication, collaboration and integration among ARCH components and investigators, NIAAA collaborators, Scientific Advisory Board, CHAART and other alcohol/HIV consortia; 2)Oversee implementation of the ARCH scientific epidemiologic and interventional aims; 3)Optimize coordination of ARCH resources among the research projects and with outside groups, particularly the data repositories, epidemiologic/ biostatistics support and the investigational expertise; 4)Promote scientific participation of junior investigators new to the field of alcohol and or HIV; 5)Support dissemination of information by ARCH investigators through presentations, publications, web site maintenance and other strategies for public communication.