Eliminating COVID-19 disparities in partnership with underserved/vulnerable transnational communities of Arizona

项目总结/摘要 COVID-19大流行严重影响了整个亚利桑那州，但影响了沿着的社区。 与墨西哥接壤。沿着这条边境的大多数拉丁裔和美洲印第安人社区 感染率更高，获得检测和疫苗接种的机会更少。这一建议旨在增加 为这些服务不足的跨国社区提供检测和相关服务。增长的范围 目前的社区驱动和文化一致的项目将提高对护理障碍的认识， 在边境地区增加检测和疫苗接种的有效战略。该应用程序扩展了工作 亚利桑那州立大学的健康差距U 54中心补助金（RFA-MD-17-005; 5 U 54 MD 002316）及其RADx-UP补充 （3U 54 MD 002316 - 14 S1）通过减少COVID-19诊断、疫苗接种、教育、总结 （b）提供服务和保健，目标是改善脆弱和得不到充分服务的社区的健康。 本次紧急竞争修订的目的与当前U 54奖项的目的密切匹配并加强了其目的 和它的RADx-UP补充。对阿兹-墨西哥边境沿着人口的关注将增加现有的 了解受影响的不同跨国社区的资产和脆弱性， 大流行病该方法赋予当地社区权力，是数据驱动的，并创建基础设施 由社区驱动的提供护理的能力。基于社区的前瞻性研究（CBPR） 方向，修订后的补充扩大了我们现有的R.A.P.I.D.通过改善访问和 减少服务不足和脆弱人群对COVID-19检测和疫苗接种的犹豫， 边境地区。平等健康基金会（EHF）将继续作为主要的社区合作伙伴， 拟议的修订补充和ASU生物设计临床试验实验室（ABCTL）将提供， 分析唾液聚合酶链反应（PCR）检测SARS-CoV-2。当地合作伙伴 由EHF在一个社区抗击COVID-19倡议下协调， 程序.在两年内，修订后的补充计划旨在达到7,000个额外的社区成员生活 在沿着阿兹-墨西哥边境工作。来自边境社区的CDCC调查将被添加到 我们正在进行的纵向研究，以评估干预的影响，并通过比较 随机选择的参与者（N=200）与随机选择的匹配对照组（N=200） 常规检测点。我们还将在受试者中进行持续的COVID-19变体序列验证 并在出现重大变异时通知相关卫生部门。跨学科团队拥有 基础设施、能力和社区伙伴关系到位，以有效实施项目， 有效地亚利桑那州立大学现有的NIMHD资助的U 54中心，由其社区和科学咨询委员会指导 并与政府机构、部落政府、社区组织和学术界合作， 亚利桑那州立大学内的单位，是装备精良，以承担拟议的修订补充。

Project Summary/Abstract The COVID-19 pandemic significantly affects the entire State of Arizona but impacts communities along the border with Mexico disproportionally. Majority Latinx and American Indian communities along this border have higher infection rates and less access to testing and vaccination. This proposed supplement aims to increase access to testing and related services for these underserved transnational communities. The expansion of our current community-driven and culturally congruent project will advance knowledge about barriers to care and effective strategies to increase testing and vaccination in the border region. This application extends the work of ASU’s health disparities U54 center grant (RFA-MD-17-005; 5U54MD002316) and its RADx-UP supplement (3U54MD002316-14S1) by reducing disparities in COVID-19 diagnostics, vaccination, education, wraparound services and health care, with the goal of improving the health of vulnerable and underserved communities. The aims of this emergency competitive revision closely match and enhance the aims of the current U54 award and its RADx-UP supplement. The focus on populations along the AZ-Mexico border will add to existing knowledge about assets and vulnerabilities of diverse transnational communities disproportionally affected by the pandemic. The approach empowers local communities, is data driven, and creates the infrastructure capacity for community-driven delivery of care. Following a Community Based Participatory Research (CBPR) orientation, the revised supplement expands our existing R.A.P.I.D. program by improving access and decreasing hesitancy to COVID-19 testing and vaccination among underserved and vulnerable populations in the border region. Equality Health Foundation (EHF) will continue to serve as the lead community partner for the proposed revised supplement and the ASU Biodesign Clinical Testing Laboratory (ABCTL) will provide and analyze the saliva-based polymerase chain reaction (PCR) testing for SARS-CoV-2. Local partners coordinated by EHF under the One Community Initiative against COVID-19 will implement the vaccination program. Over two years, the revised supplement aims to reach 7,000 additional community members living and working along the AZ-Mexico border. CDCC surveys from border communities will be added to the ongoing longitudinal study we are conducting to assess the intervention’s impact and also by comparing randomly selected participants (N=200) with a matched comparison group (N=200) randomly selected from regular testing sites. We will also conduct ongoing COVID-19 variants sequence validation among those tested and inform appropriate health authorities if significant variants emerge. The transdisciplinary team has the infrastructure, capacity, and community partnerships in place to implement the project effectively and efficiently. ASU’s existing NIMHD-funded U54 center, guided by its Community and Scientific Advisory Board and in collaboration with government agencies, tribal governments, community organizations, and academic units within ASU, is well equipped to undertake the proposed revised supplement.